Abstract: A computer-implemented method (300) of operating a telecommunications network (110-1), said telecommunications network comprising a plurality of nodes (150), and the method comprising the steps of: storing: a set of historic reconfiguration instructions, said instructions having been used to reconfigure the telecommunications network; first status information from each of the plurality of nodes, wherein said first status information is received prior to reconfiguring the telecommunications network according to a given historic reconfiguration instruction; and second status information from each of the plurality of nodes, wherein said second status information is received after reconfiguring the telecommunications network according to the given historic reconfiguration instruction; receiving a new reconfiguration instruction (310); prior to reconfiguring the telecommunications network according to the new reconfiguration instruction, identifying from the set a similar historic reconfiguration instruction havin

Abstract: An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.

Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.

Abstract: A method for controlling charging a power source of an implantable medical device (IMD) in a patient including determining a power being delivered to a primary coil of an external charging device for recharging, determining an estimated power delivered to the IMD power source an estimated heat generated by the primary coil based on a resistance of the primary coil determined as function of at least one of a recharge frequency, a temperature of the primary coil, and a current supplied to the primary coil, calculating an estimated heat generated by the IMD by subtracting the estimated heat generated by the primary coil and the estimated power delivered stored by the rechargeable power source from the power being delivered to a primary coil; and controlling based on the heat generated by the IMD, the power being delivered by the primary coil of the external charging device.

Abstract: Detecting analytes using proximity-induced tagmentation, strand invasion, restriction, or ligation is provided herein. In some examples, detecting an analyte includes coupling a donor recognition probe to a first portion of the analyte. The donor recognition probe includes a first recognition element specific to the first portion of the analyte, a first oligonucleotide corresponding to the first portion, and a transposase coupled to the first recognition element and the first oligonucleotide. An acceptor recognition probe is coupled to a second portion of the analyte. The acceptor recognition probe includes a second recognition element specific to the second portion of the analyte and a second oligonucleotide coupled to the second recognition element and corresponding to the second portion. The transposase is used to generate a reporter polynucleotide including the first and second oligonucleotides. The analyte is detected based on the reporter including comprising the first and second oligonucleotides.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: Embodiments of the present disclosure relate to nucleotides labeled with photoswitchable compounds. Also provided herein are methods and kits of using these labeled nucleotides for sequencing applications.

Abstract: In some examples, novel nanogel particles are described having dual functionality, temperature responsiveness and pH responsiveness. For nucleic acid sequencing, amplification primers are grafted to nanogel particles to form primer-grafted nanogel particles, and the primer-grafted nanogel particles are captured onto surfaces within a flow cell. Within flow cells such as used in SBS nucleic acid sequencing, each primer-grafted nanogel particle functions as a nano-well in the flow cell, thus eliminating the need for nano-wells in some examples.

Abstract: An example of a flow cell includes a base support, a reversibly swellable resin positioned over the base support, and a depression defined in the reversibly swellable resin. The reversibly swellable resin includes at least one hydrophilic monomer selected from the group consisting of a poly(ethylene glycol) based monomer, poly(propylene glycol) based monomer, and combinations thereof. The depression has a first opening dimension when the reversibly swellable resin is in a non-swelled stated and has a second opening dimension, that is smaller than the first opening dimension, when the reversibly swellable resin is in a swelled state.

Abstract: The present disclosure provides three-dimensional (3D) printing systems, devices, apparatuses, methods, and non-transitory computer readable media associated with 3D printing systems that include dynamically movable optical components operatively coupled with a translation mechanism, e.g., comprising an optical image generator, a detector, or an optical assembly configured to direct a printing agent such as an energy beam. The present disclosure includes resulting objects printed in the 3D printing systems, as well as various other components relating to a 3D printing system.

Abstract: An example of an array includes a support, a cross-linked epoxy polyhedral oligomeric silsesquioxane (POSS) resin film on a surface of the support, and a patterned hydrophobic polymer layer on the cross-linked epoxy POSS resin film. The patterned hydrophobic polymer layer defines exposed discrete areas of the cross-linked epoxy POSS resin film, and a polymer coating is attached to the exposed discrete areas. Another example of an array includes a support, a modified epoxy POSS resin film on a surface of the support, and a patterned hydrophobic polymer layer on the modified epoxy POSS resin film. The modified epoxy POSS resin film includes a polymer growth initiation site, and the patterned hydrophobic polymer layer defines exposed discrete areas of the modified epoxy POSS resin film. A polymer brush is attached to the polymer growth initiation site in the exposed discrete areas.

Abstract: A whipstock assembly (12) for use in deviating a wellbore (10) of a well is disclosed, the whipstock assembly comprising a whipstock (18) having an inclined deflection surface (20); a milling assembly (14) comprising a mill (16) for milling a window (49) in a wall (48) of the wellbore and forming a rathole (50) extending from the wellbore; a releasable joint (22; 122) by which the milling assembly is releasably connected to the whipstock, so that the milling assembly can be separated from the whipstock within the wellbore and subsequently deflected towards the wellbore wall by the deflection surface of the whipstock; at least one sensor (188) provided in the milling assembly, for measuring at least one parameter of the rathole, the at least one parameter relating to a trajectory of the rathole; and a communication device (190) associated with the at least one sensor, for communicating data relating to the at least one parameter to an operator of the milling assembly.

Abstract: Various embodiments of a voltage detection device and of related safety systems are provided. In various embodiments, the voltage detection device is configured to couple to safety headwear, such as via the one or more housing(s) of the voltage detection device coupling directly to the safety headwear or the voltage detection device coupling to an adaptor mounted to the hard hat.

Abstract: A method of deception detection based upon ocular information of a subject provides a video camera configured to record a close-up view of a subject's eye. A cognitive state model is configured to determine a high to a low cognitive load experienced by the subject. An emotional state model is configured to determine a high to a low state of arousal experienced by the subject. After asking a question, the ocular information is processed to identify changes in ocular signals of the subject. The cognitive state and emotional state models are evaluated based solely on the changes in ocular signals where a probability of the subject being either truthful or deceptive is estimated for a binary output.

Abstract: An SMA actuation apparatus (1) comprises a support structure (2) and a movable element (3) supported thereon by a suspension system (8, 10) that supports the movable element on the support structure and guides movement of the movable element along a movement axis. Two closely spaced lengths of SMA wire (4) that are close to parallel and inclined at the same acute angle with respect to a plane normal to the movement axis are connected to the support structure and to the movable element so as to apply respective forces to the movable element with respective components parallel to the movement axis that are in opposite directions. The two lengths of shape memory alloy wire apply a couple to the movable element perpendicular to the movement axis and the suspension system includes a pair of flexures or bearings that resist the resultant couple applied to the movable element by the lengths of SMA wire.

Abstract: The present invention is directed to an electrodepositable coating composition comprising an electrodepositable binder comprising an ionic salt group-containing film-forming polymer comprising active hydrogen functional groups, and a blocked polyisocyanate curing agent; a solubilized bismuth catalyst; and a guanidine; wherein the electrodepositable coating composition has a weight ratio of bismuth metal from the solubilized bismuth catalyst to guanidine of from 1.00:0.071 to 1.0:2.1 and/or a molar ratio of bismuth metal to guanidine of from 1.0:0.25 to 1.0:3.0. Also disclosed are methods of treating electrodepositable coating compositions, methods for making electrodepositable coating compositions, systems for coating a metal substrate, coatings, coated substrates, and methods of coating a substrate.

Abstract: A load-monitoring system includes a vehicle processor and a camera mounted in a trailer. The vehicle, via the processor, displays a first image of a trailer load, received from a trailer-mounted camera and receives selection of a monitoring point on the image, via a touch-sensitive user interface displaying the image or other selection mechanism. The vehicle also receives selection of a fixed point on the image, via the user interface. If the monitoring point moves more than a threshold amount, relative to the fixed point, for example, in subsequent images captured by the camera, the vehicle alerts the driver.

Abstract: The present application provides a collector terminal dust mitigation assembly for use with collector terminals of generators to prevent dust entry into a collector terminal bore in a collector ring, wherein the collector terminals may have varying positions with respect to the collector rings. The collector terminal dust mitigation assembly may include one of a number of inner elements configured for a specific position of a collector terminal with respect to a collector ring and a standard outer element sized to accommodate the inner element.

Abstract: The present application provides methods of treating urticaria in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound which inhibits JAK1, or a pharmaceutically acceptable salt thereof.

Abstract: An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.