Abstract: A security device, including at least first and second embossed, reflective metal diffraction gratings in respective regions: wherein the first diffraction grating exhibits, in incident white light, a zero-order output over a first area of substantially uniform grating period, wherein the zero-order output of the first diffraction grating comprises different coloured first and second sub-outputs for respective first and second polarisations parallel and perpendicular to the first diffraction grating; wherein the second diffraction grating exhibits, in incident white light, a zero-order output over a second area of substantially uniform grating period; wherein the zero-order output of the second diffraction grating comprises third and fourth sub-outputs for respective first and second polarisations parallel and perpendicular to the second diffraction grating; and wherein the first and second diffraction gratings exhibit, for incident white light, substantially the same first order diffraction efficiency over t

Abstract: In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Abstract: A wellhead assembly includes a containment system having a mechanical barrier, a tertiary wiper, and a fluid jet assembly. A mechanical barrier includes a body disposed in a housing, the body having an opening extending through an axial thickness of the body. A tertiary wiper has an elastomeric body with a hole extending centrally therethrough. A fluid jet assembly includes a jet assembly body having a wall defining a cavity extending axially through the jet assembly body and an array of nozzles positioned circumferentially around the wall, wherein each nozzle has an outlet directed in a radially inward direction from the wall toward a central region in the cavity. The components of the containment system are arranged an axially stacked arrangement relative to each other.

Abstract: A multi-module wearable device. According to an embodiment of the present disclosure, there is provided a system, including: a first wearable instrument; a second wearable instrument including a biometric sensor; an electrical connection between the first wearable instrument and the second wearable instrument; and a strap, sized and dimensioned to be disposed about a wrist. The electrical connection may be capable of connecting the first wearable instrument to the second wearable instrument when the second wearable instrument is at a first position on the strap relative to the first wearable instrument, and of connecting the first wearable instrument to the second wearable instrument when the second wearable instrument is at a second position on the strap relative to the first wearable instrument.

Abstract: A computer device which is configured to provide a computer game responsive to user inputs, the computer device having a user interface comprising a display which is configured to display an initial game board of the computer game comprising user actuatable game elements and an avatar element at an initial avatar location of the game board. The gameboard includes an activation element on the game board. An activation condition from an interacting event with the activation element is detected and, responsive to the detection of the activation condition, a path segment extending from the avatar location to a next location on a predetermined path is unlocked. If the path segment is in a first state which permits movement of the avatar element from the avatar location to the next location, the avatar element is automatically moved from the avatar location to the next location without detecting further user input.

Abstract: A flow control system and method of detecting a condition of a pump set mounted on the apparatus. The system configured to perform the method of advancing a first amount of the feeding formula through the feeding pump via a feeding formula conduit. Further, the system may acquire a first pressure sensor reading of the feeding formula conduit. Further, the system may advance a second amount of the feeding formula through the feeding pump via the feeding formula conduit, wherein the second amount is second volume of the liquid. Further, the system may acquire a second pressure sensor reading of the feeding formula conduit, and acquire a third pressure sensor reading of the feeding formula conduit. Further, the system may detect an occlusion in the feeding formula conduit based on at least one of the first pressure sensor reading, the second pressure sensor reading and the third pressure sensor reading.

Abstract: A computing platform is configured to (i) receive data objects related to a construction project, (ii) add the data objects to a construction knowledge graph as nodes that are connected to other nodes representing other data objects, (iii) determine, via a machine-learning model trained using historic construction project data, a first risk score for a first data object, (iv) determine, via the machine-learning model, a second risk score for a second data object, where the second risk score is based on (a) the first risk score and (b) a degree of separation between the first data object and the second data object in the construction knowledge graph, (v) based on the second risk score, automatically generate a suggested action to be taken with respect to the first data object, and (vi) cause an indication of the suggested action to be displayed at a client station of a user associated with the construction project.

Abstract: The invention includes compositions and methods for promoting gas mixtures separations, such as a carbon dioxide and methane mixture. The composition of the invention is based on a curable polymerized room-temperature ionic liquid [poly(RTIL)].

Abstract: A drug delivery device includes a housing, a container at least partially disposed within the housing and configured to contain a medicament, an injection mechanism at least partially disposed within the housing and configured to exert a force to urge the medicament from the container, a drug delivery component at least partially disposed within the housing, and at least one pin positioned adjacent to the housing and preventing activation of the activation mechanism until the at least one pin reaches a desired temperature.

Abstract: Disclosed herein are nanoparticle compositions containing that may be created by functionalizing polyethylenimine (PEI) with fatty acids and carboxylate terminated poly(ethylene glycol) (PEG). The disclosed compositions may be delivered to an individual in need thereof via delivery into blood circulation, where the nanoparticle compositions show an exceptionally high specificity to the pulmonary microvascular endothelium with minimal targeting of other cell types in the lung, to provide delivery of therapeutic agents such as stabilized nucleic acids. Methods of using the compositions are also disclosed.

Abstract: Existing single cell analysis techniques are generally high-resolution but are limited in the number of possible different experimental conditions. Disclosed herein are compositions and methods for multiplexed barcoding of a heterogenous population of cells using cationic polymers for delivery of nucleic acid barcodes to a cell population.

Abstract: The present disclosure provides a system and method for locating terminals within a facility. One or more of a plurality of primary terminals send a location signal which may comprise location data for the respective primary terminal. A secondary terminal, of a plurality of secondary terminals may receive one or more of these location signals. In response, the secondary terminal sends a confirmation message to each primary terminal from which it has received a location signal. The confirmation message may comprise a unique identifier for the secondary terminal. In response to receiving one or more confirmation messages, a primary terminal sends a location reporting message to a location processing server. The location reporting message comprises the location data for that primary terminal and the contents of the received confirmation message(s). The data held on the location processing server can be used to determine the location and movement of each of the primary terminals and the secondary terminals.

Abstract: The invention includes compositions and methods for promoting gas mixtures separations, such as a carbon dioxide and methane mixture. The composition of the invention is based on a curable polymerized room-temperature ionic liquid [poly(RTIL)].

Abstract: The present disclosure provides a system and method for locating terminals within a facility. One or more of a plurality of primary terminals send a location signal which may comprise location data for the respective primary terminal. A secondary terminal, of a plurality of secondary terminals may receive one or more of these location signals. In response, the secondary terminal sends a confirmation message to each primary terminal from which it has received a location signal. The confirmation message may comprise a unique identifier for the secondary terminal. In response to receiving one or more confirmation messages, a primary terminal sends a location reporting message to a location processing server. The location reporting message comprises the location data for that primary terminal and the contents of the received confirmation message(s). The data held on the location processing server can be used to determine the location and movement of each of the primary terminals and the secondary terminals.

Abstract: Disclosed herein are nanoparticle compositions containing that may be created by functionalizing polyethylenimine (PEI) with fatty acids and carboxylate terminated poly(ethylene glycol) (PEG). The disclosed compositions may be delivered to an individual in need thereof via delivery into blood circulation, where the nanoparticle compositions show an exceptionally high specificity to the pulmonary microvascular endothelium with minimal targeting of other cell types in the lung, to provide delivery of therapeutic agents such as stabilized nucleic acids. Methods of using the compositions are also disclosed.

Abstract: In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Abstract: Embodiments of the present invention provide a vent arrangement integrated with a refill port disposed on the outer shell of an implantable drug-delivery device. The vent arrangement may utilize a tiered structure with two septums in a space-efficient configuration that facilitates both venting of pressure and refill of the drug reservoir.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: Tubular polymeric structures are formed by creating a convex mold conforming to a fluid pathway design, depositing a coating of polymer over the mold, and in situ removing the mold without drawing it against the polymer. The resulting structures are fabricated with flow-altering features.