Abstract: In various embodiments, approaches to calibrating an implantable drug-delivery device feature a drug reservoir, an expandable electrolysis chamber, and an integrated strain gauge using a refill apparatus having one or more pumps, one or more refill reservoirs, an outlet fluid channel fluidically connected to the refill reservoir(s), and a needle having a lumen in fluid communication with the outlet fluid channel include inserting a needle into a refill port of the implantable drug-delivery device, monitoring a pressure change within the device, monitoring a pressure level of one or more components of the implantable drug-delivery device, and calibrating the monitored pressure level of the component(s) of the implantable drug-delivery device to the monitored pressure level of the outlet fluid channel.

Abstract: Systems and methods for particle tracking using spatiotemporal offset light beams. In exemplary embodiments, the optical systems and methods can be used with conventional two-photon microscopy equipment to perform high speed, high precision, and deep tissue three-dimensional single-particle tracking. Exemplary embodiments can be configured for single-molecule studies of biological diffusion and transport processes.

Abstract: A quantum compiler is provided. The quantum compiler may generate, based on a text-based programmer input, an executable Hamiltonian for a quantum computer such as a quantum annealing computer or an adiabatic quantum computer. The quantum compiler may generate the program Hamiltonian by generating Hamiltonian phrases corresponding to portions of the programmer input and combining the Hamiltonian phrases. Various terms and values in the program Hamiltonian may correspond to physical features of the quantum computer so that the quantum computer can be operated, based on the program Hamiltonian, such that a low energy state of the quantum computer corresponds to the low energy state of the Hamiltonian.

Abstract: Tubular polymeric structures are formed by creating a convex mold conforming to a fluid pathway design, depositing a coating of polymer over the mold, and in situ removing the mold without drawing it against the polymer.

Abstract: A system and method for avoiding object identifier collisions in a cluster environment is provided. Upon creation of the cluster, volume location databases negotiate ranges for data set identifiers (DSIDs) between a first site and a second site of the cluster. Any pre-existing objects are remapped into an object identifier range associated with the particular site hosting the object.

Abstract: Systems and methods for particle tracking using spatiotemporal offset light beams. In exemplary embodiments, the optical systems and methods can be used with conventional two-photon microscopy equipment to perform high speed, high precision, and deep tissue three-dimensional single-particle tracking. Exemplary embodiments can be configured for single-molecule studies of biological diffusion and transport processes.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: In various embodiments, an implantable drug-delivery device features drug-delivery and electrolysis chambers incorporated as separate structures within the device. For example, one or both of these chambers may be manufactured in the form of a bladder that “floats” within the main device housing.

Abstract: In various embodiments, implantable drug-delivery devices feature drug reservoirs, expandable electrolysis chambers, and integrated strain gauges for monitoring pressure changes within the device.

Abstract: In various embodiments, an implantable drug-delivery device features one or more rigid drug reservoirs from which therapeutic agents are administered and which are refilled from a flexible reservoir within the device.

Abstract: In one embodiment, a method comprises determining that a participant image has a distorted view relative to an optimized view of a participant within a corresponding participant image frame for a web-based videoconference with a presenter; and sending, to a display of a device having generated the participant image, a distorted image of the presenter corresponding to the distorted view in the participant image frame, enabling the participant to adjust the device to minimize the distorted view.

Abstract: A system and method for avoiding object identifier collisions in a cluster environment is provided. Upon creation of the cluster, volume location databases negotiate ranges for data set identifiers (DSIDs) between a first site and a second site of the cluster. Any pre-existing objects are remapped into an object identifier range associated with the particular site hosting the object.

Abstract: Tubular polymeric structures are formed by creating a convex mold conforming to a fluid pathway design, depositing a coating of polymer over the mold, and in situ removing the mold without drawing it against the polymer. The resulting structures are fabricated with flow-altering features.

Abstract: Refill needles include a refill lumen for refilling a drug reservoir with a liquid and a venting channel for venting the device to be refilled. In various embodiments, the termini of the refill lumen and the venting channel are longitudinally displaced along the needle.

Abstract: Guest domains (virtual machines) may execute at a virtualization server. During execution, the guest domains may request various services to facilitate their operation. The virtualization server may disaggregate the services requested by the guest domains among various service domains. A service domain may be configured to provide one the services. The virtualization server may also maintain a pool of partially initialized service domains. When a guest domain requests a particular service, one of the partially initialized service domains may be selected from the pool, and the partially initialized service domain may complete initialization to become an initialized service domain. The initialized service domain may thus be configured to provide the service requested by a guest domain. The virtualization server may periodically replenish the pool of partially initialized service domains to ensure that a partially initialized service domain is available upon demand from one of the guest domains.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: In an on-line method of analyzing financial accounting data, uploaded financial accounting data is received at a server (2) from a client computer (3). The data is analyzed at the server (2) to identify anomalies in the data. A display is provided at the client computer (3) representing the anomalies that have been identified. Further, in a method of pre-processing financial accounting data prior to analyzis of the data, the financial accounting data is abstracted to correspond to a pre-stored accounting ontology. Further, in a method of analyzing financial accounting data, the method checks the data for violation of a particular state to identify inconsistent combinations of values in the data.

Abstract: Methods of imaging are provided. In some embodiments, the methods may comprise obtaining a raw speckle image of a sample, converting the raw speckle image to a laser speckle contrast image using a laser speckle contrast algorithm, and converting a laser speckle contrast image to a relative correlation time image using a relative correlation time algorithm.

Abstract: In one embodiment, a method comprises determining that a participant image has a distorted view relative to an optimized view of a participant within a corresponding participant image frame for a web-based videoconference with a presenter; and sending, to a display of a device having generated the participant image, a distorted image of the presenter corresponding to the distorted view in the participant image frame, enabling the participant to adjust the device to minimize the distorted view.