Patents by Inventor Andrew S. Goldstein
Andrew S. Goldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150216471Abstract: Detection of one or more fronts of saliva advancing simultaneously in multiple directions may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. An array of electrical contacts may be arranged between a substrate and a liquid collection element, and used to detect saliva migrating through the liquid collection element. A substrate may include a leading edge defining a notch or recess to receive a sublingual frenulum for positioning a liquid collection element proximate to a sublingual salivary duct, or may include a flexible substrate for positioning a liquid collection element in an oral cavity proximate to at least one parotid or minor salivary duct. Sensing of salivary flow rate may be augmented by measuring concentration of at least one analyte in saliva and/or sensing various environmental factors. Groups of electrical contacts may be arranged proximate to different salivary glands or ducts.Type: ApplicationFiled: August 15, 2013Publication date: August 6, 2015Applicant: HYDRADX INC.Inventors: Andrew S. Goldstein, Kirk Charles Harmon
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Patent number: 8611992Abstract: Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.Type: GrantFiled: July 3, 2012Date of Patent: December 17, 2013Assignee: HydraDx, Inc.Inventors: Andrew S. Goldstein, Frank Bellizzi
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Patent number: 8326412Abstract: Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.Type: GrantFiled: September 30, 2011Date of Patent: December 4, 2012Assignee: HydraDx, Inc.Inventors: Andrew S. Goldstein, Frank Bellizzi
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Publication number: 20120289863Abstract: Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.Type: ApplicationFiled: July 3, 2012Publication date: November 15, 2012Applicant: HYDRADX, INC.Inventors: Andrew S. Goldstein, Frank Bellizzi
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Publication number: 20120149124Abstract: A method and a device for collection and assay of oral fluids are disclosed. The method places an assay device into an oral cavity, removes the device, and determines the presence or absence of an analyte. The assay device comprises an assay portion housing a lateral flow assay strip, a neck portion extending from the assay portion and forming a channel for fluid delivery to the assay strip; a collection strip in fluid communication with the lateral flow assay strip; and a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip. The channel is defined by a narrow part proximal to the assay portion and a part which receives oral fluid and has a substantially wider channel width. The collection strip has a first portion disposed within the channel and a second portion protruding outwardly from the neck opening.Type: ApplicationFiled: November 21, 2011Publication date: June 14, 2012Applicant: ORASURE TECHNOLOGIES, INC.Inventors: Ronald W. MINK, Andrew S. GOLDSTEIN, Robert C. BOHANNON
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Publication number: 20120083711Abstract: Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.Type: ApplicationFiled: September 30, 2011Publication date: April 5, 2012Applicant: HYDRADX, INC.Inventors: Andrew S. Goldstein, Frank Bellizzi
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Patent number: 8062908Abstract: A method for rapid collection and assay of oral fluids is disclosed. The method comprising the steps of: (a) placing an assay device into an oral cavity, (b) removing said assay device from said oral cavity; and (c) determining the presence or absence of at least one analyte.Type: GrantFiled: January 8, 2009Date of Patent: November 22, 2011Assignee: OraSure Technologies, Inc.Inventors: Ronald W. Mink, Andrew S. Goldstein, Robert C. Bohannon
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Publication number: 20100239458Abstract: An apparatus and process for transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. A lateral chromatographic strip is placed within a cavity defined in a housing. The lateral chromatography strip extends within the cavity and is disposed along the housing to an inspection site. At least one inspection site to the lateral chromate phic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. This porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption.Type: ApplicationFiled: August 20, 2009Publication date: September 23, 2010Applicant: OraSure Technologies, Inc.Inventors: Ronald W. Mink, Andrew S. Goldstein, Robert C. Bohannon
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Publication number: 20090170072Abstract: A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids.Type: ApplicationFiled: January 8, 2009Publication date: July 2, 2009Applicant: OraSure Technologies, Inc.Inventors: Ronald W. MINK, Andrew S. GOLDSTEIN, Robert C. BOHANNON
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Patent number: 7544468Abstract: This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of the diagnostic information from the genomic information. It is a surprising discovery of this invention that a PCR assay on the contents of the bibulous pad provides results comparable in reliability, specificity, and sensitivity to the best available serum (blood) based assays. The assays of this invention can be used to confirm each other, either by detecting the genomic information leading to the diagnostic information, or by detecting in the genomic information, a predisposition to a disease and confirming the presence of the disease through diagnostic testing.Type: GrantFiled: October 25, 2001Date of Patent: June 9, 2009Assignee: Orasure Technologies, Inc.Inventors: Andrew S. Goldstein, Richard K. Bestwick
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Patent number: 7541194Abstract: A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids.Type: GrantFiled: January 17, 2007Date of Patent: June 2, 2009Assignee: Orasure Technologies, Inc.Inventors: Ronald W. Mink, Andrew S. Goldstein, Robert C. Bohannon
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Patent number: 7192555Abstract: A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids.Type: GrantFiled: October 11, 2001Date of Patent: March 20, 2007Assignee: Orasure Technologies, Inc.Inventors: Ronald W. Mink, Andrew S. Goldstein, Robert C. Bohannon
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Publication number: 20020192839Abstract: An apparatus and process for transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. A lateral chromatographic strip is placed within a cavity defined in a housing. The lateral chromatography strip extends within the cavity and is disposed along the housing to an inspection site. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. This porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption.Type: ApplicationFiled: February 19, 2002Publication date: December 19, 2002Applicant: EPITOPE, INC.Inventors: Ronald W. Mink, Andrew S. Goldstein, Robert C. Bohannon
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Publication number: 20020155029Abstract: A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids.Type: ApplicationFiled: October 11, 2001Publication date: October 24, 2002Applicant: Epitope, Inc.Inventors: Ronald W. Mink, Andrew S. Goldstein
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Publication number: 20020115089Abstract: This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of the diagnostic information from the genomic information. It is a surprising discovery of this invention that a PCR assay on the contents of the bibulous pad provides results comparable in reliability, specificity, and sensitivity to the best available serum (blood) based assays. The assays of this invention can be used to confirm each other, either by detecting the genomic information leading to the diagnostic information, or by detecting in the genomic information, a predisposition to a disease and confirming the presence of the disease through diagnostic testing.Type: ApplicationFiled: October 25, 2001Publication date: August 22, 2002Applicant: OraSure Technologies, Inc.Inventors: Andrew S. Goldstein, Richard K. Bestwick
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Publication number: 20020015663Abstract: A device for obtaining oral fluid containing substances for testing. In one embodiment, the device includes a syringe having a plunger at the end of which an absorbent pad is attached. A test assembly containing the device is also disclosed.Type: ApplicationFiled: July 10, 1998Publication date: February 7, 2002Inventors: ANDREW S. GOLDSTEIN, STEFAN GAVOJDEA, DAVID F. ZOGG
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Patent number: 6309827Abstract: This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of the diagnostic information from the genomic information. It is a surprising discovery of this invention that a PCR assay on the contents of the bibulous pad provides results comparable in reliability, specificity, and sensitivity to the best available serum (blood) based assays. The assays of this invention can be used to confirm each other, either by detecting the genomic information leading to the diagnostic information, or by detecting in the genomic information, a predisposition to a disease and confirming the presence of the disease through diagnostic testing.Type: GrantFiled: March 27, 1998Date of Patent: October 30, 2001Assignee: OraSure Technologies, Inc.Inventors: Andrew S. Goldstein, Richard K. Bestwick
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Patent number: 6303081Abstract: A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids.Type: GrantFiled: April 15, 1999Date of Patent: October 16, 2001Assignee: OraSure Technologies, Inc.Inventors: Ronald W. Mink, Andrew S. Goldstein
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Patent number: 5830410Abstract: A device for obtaining oral fluid containing substances for testing. In one embodiment, the device includes a syringe having a plunger at the end of which an absorbent pad is attached. A test assembly containing the device is also disclosed.Type: GrantFiled: June 1, 1995Date of Patent: November 3, 1998Assignee: Epitope, Inc.Inventors: Thomas R. Thieme, Andrew S. Goldstein, Stephen C. Piacentini, Nanette M. Klimkow
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Patent number: 5736322Abstract: A substitute oral fluid standard for testing, calibration, and standardization of devices and methods for collection, storage, and analysis of oral fluids. The oral fluid standard comprises a mucin and a protease inhibitor.Type: GrantFiled: February 28, 1996Date of Patent: April 7, 1998Assignee: Epitope, Inc.Inventor: Andrew S. Goldstein