Abstract: Provided are compounds of Formula (I?) or (II?), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: Systems and methods are disclosed for automatically determining property value, the systems and methods perform operations comprising: receiving, by a server, subject real-estate property listing information associated with a subject real-estate property; identifying a plurality of comparable real-estate property listings based on attributes of the subject real-estate property listing information; processing the subject real-estate property listing information together with the plurality of comparable real-estate property listings using a trained machine learning technique to predict a value for the subject real-estate property, the trained machine learning technique being trained to jointly establish a relationship between weights assigned to a set of training comparable real-estate property listings and value adjustments of the set of training comparable real-estate property listings and a value of a real-estate property of interest; and performing an action with respect to the subject real-estate property

Abstract: The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R5, R6, and = are as defined herein. The present invention also relates to compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: Provided are compounds of Formula (I?) or (I) below, or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: Techniques for detecting motion of a vehicle are disclosed. Optical flow techniques are applied to the entirety of the received images from an optical sensor mounted to a vehicle. Motion detection techniques are then imposed on the optical flow output to remove image portions that correspond to objects moving independent from the vehicle and determine the extent, if any, of movement by the vehicle from the remaining image portions. Motion detection can be performed via a machine learning classifier. In some aspects, motion can be detected by extracting the depth of received images in addition to optical flow. In additional or alternative aspects, the optical flow and/or motion detection techniques can be implemented by at least one artificial neural network.

Abstract: Systems and methods for a tightly coupled end-to-end multi-sensor fusion with integrated compensation are described herein. For example, a system includes an inertial measurement unit that produces inertial measurements. Additionally, the system includes additional sensors that produce additional measurements. Further, the system includes one or more memory units. Moreover, the system includes one or more processors configured to receive the inertial measurements and the additional measurements. Additionally, the one or more processors are configured to compensate the inertial measurements with a compensation model stored on the one or more memory units. Also, the one or more processors are configured to fuse the inertial measurements with the additional measurements using a differential filter that applies filter coefficients stored on the one or more memory units.

Abstract: A charging structure for a vaporizer. The charging structure includes a housing, a first electrical contact coupled to and extending outward from a first end of the housing, a spacer coupled to the first electrical contact, and a second electrical contact coupled to and extending outward from the spacer. The first electrical contact includes an exposed outer surface that extends in a continuous loop. The second electrical contact includes an exposed side surface that extends in a continuous loop and an end surface coupled to the side surface. Both the side surface and the end surface are electrically conductive. A vaporizer including the charging structure.

Abstract: Systems and methods are disclosed for automatically determining property value, the systems and methods perform operations comprising: receiving, by a server, subject real-estate property listing information associated with a subject real-estate property; identifying a plurality of comparable real-estate property listings based on attributes of the subject real-estate property listing information; processing the subject real-estate property listing information together with the plurality of comparable real-estate property listings using a trained machine learning technique to predict a value for the subject real-estate property, the trained machine learning technique being trained to jointly establish a relationship between weights assigned to a set of training comparable real-estate property listings and value adjustments of the set of training comparable real-estate property listings and a value of a real-estate property of interest; and performing an action with respect to the subject real-estate property

Abstract: Disclosed techniques relate to storing a key cache within a secure enclave. In some embodiments, a computing system receives, from an application, a request to access a database, where the request is associated with a particular account. The computing system then accesses, using an identifier associated with the particular account, a key cache stored in a secure enclave of a memory of the computing system to determine at least one private key associated with the request, where the key cache stores private keys of a key management system (KMS) for a plurality of accounts. The computing system performs a cryptographic operation for accessing the database within the secure enclave using the at least one private key. In various embodiments, disclosed techniques may improve the security of cryptographic private keys cached for a plurality of tenants.

Abstract: The present invention provides a wood preservative formulation comprising an isothiazolone, an organic fungicidal timber decay preservative and an unsaturated carboxylic or sulphonic acid, salt or anhydride thereof. The formulations of the invention are surprisingly effective at protecting wood and other cellulosic substrates, in particular at providing prolonged protection against in-service surface staining. The invention also provides methods for treating wood and other cellulosic substrates with said formulations.

Abstract: Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.

Abstract: Systems and methods are disclosed for automatically determining property value, the systems and methods perform operations comprising: receiving, by a server, subject real-estate property listing information associated with a subject real-estate property; identifying a plurality of comparable real-estate property listings based on attributes of the subject real-estate property listing information; processing the subject real-estate property listing information together with the plurality of comparable real-estate property listings using a trained machine learning technique to predict a value for the subject real-estate property, the trained machine learning technique being trained to jointly establish a relationship between weights assigned to a set of training comparable real-estate property listings and value adjustments of the set of training comparable real-estate property listings and a value of a real-estate property of interest; and performing an action with respect to the subject real-estate property

Abstract: Techniques for detecting motion of a vehicle are disclosed. Optical flow techniques are applied to the entirety of the received images from an optical sensor mounted to a vehicle. Motion detection techniques are then imposed on the optical flow output to remove image portions that correspond to objects moving independent from the vehicle and determine the extent, if any, of movement by the vehicle from the remaining image portions. Motion detection can be performed via a machine learning classifier. In some aspects, motion can be detected by extracting the depth of received images in addition to optical flow. In additional or alternative aspects, the optical flow and/or motion detection techniques can be implemented by at least one artificial neural network.

Abstract: Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.

Abstract: Vape devices and methods of operating the same to prevent unauthorized use, allow for remote, centralized storage of operational settings associated with unique payload identifiers, and to optimize operation based on historical usage data, real-time operating conditions, and/or user information. Vape devices for vaporizing dry material and methods of operating the same. Tablets comprising dry material for vaporization and methods of making and using the same. Vape devices and cartridges to improve flow of a fluid payload to an atomizer and to prevent leaking and spurting of the fluid payload, including vape devices and cartridges that pressurize the fluid payload. Vapor measurement systems to determine dosage based on a measured capacitance of vaporized payload. A two-lead communication system that enables the communication of a plurality of electrical signals between a control assembly and cartridge. A cartridge temperature control system that provides localized temperature control for the cartridge.

Abstract: An Inertial Measurement Unit (IMU), method, and navigation system are disclosed. For example, the method includes receiving a plurality of sensor values from an IMU, loading the plurality of sensor values and a plurality of true sensor values into a deep learning algorithm, and training the deep learning algorithm to enhance the accuracy of the plurality of sensor values utilizing the plurality of true sensor values.

Abstract: There is provided a fan assembly comprising a fan body, a motor-driven impeller contained within the fan body and arranged to generate an air flow, a nozzle comprising a nozzle body having an air inlet arranged to receive the air flow from the fan body and one or more air outlets arranged to emit the airflow from the fan assembly. The fan assembly further comprises a nozzle retaining mechanism for releasably retaining the nozzle on the fan body, and a rotation mechanism for rotating the nozzle body relative to the fan body. The nozzle rotation mechanism comprises a rotation motor arranged to drive a drive member and a driven member that is arranged to be driven by the drive member to rotate around a rotation axis, wherein the nozzle body comprises the driven member and the fan body comprises the rotation motor and the drive member.

Abstract: A vape device system including a payload reservoir that is identified by a payload identifier and that is configured to hold a substance for atomization. A processor is configured to determine an operational setting based on at least one of the payload identifier and a secondary data, which may include user information, prescription information, location information, payload information, historical vape device usage information, and historical payload reservoir information. A vape device system, and method of using the same, that includes a vape device and a computing device that includes the processor. A method of controlling a vape device including determining an operational setting of the vape device based on the payload identifier and/or secondary data. The operational settings may include a duty cycle setting, a temperature setting, an operational time duration, a dosage setting, and a security setting.

Abstract: Disclosed techniques relate to storing a key cache within a secure enclave. In some embodiments, a computing system receives, from an application, a request to access a database, where the request is associated with a particular account. The computing system then accesses, using an identifier associated with the particular account, a key cache stored in a secure enclave of a memory of the computing system to determine at least one private key associated with the request, where the key cache stores private keys of a key management system (KMS) for a plurality of accounts. The computing system performs a cryptographic operation for accessing the database within the secure enclave using the at least one private key. In various embodiments, disclosed techniques may improve the security of cryptographic private keys cached for a plurality of tenants.