Abstract: A sterilizable pouch having both internal and external sterilization record indicators to indicate whether attempted steam sterilization of the pouch and contents was successful or unsuccessful. The pouch preferably has one indicium in each indicator responsive to multi-parameter sterilization by steam, and another indicium in each indicator responsive to gas sterilization, such as using ethylene oxide.

Abstract: A layer of single crystal CVD diamond of high quality having a thickness greater than 2 mm. Also provided is a method of producing such a CVD diamond layer.

Abstract: A composite guidewire comprising a proximal wire segment having a proximal end, a distal end and a longitudinal axis extending therebetween, the distal end being formed with a first flat planar bonding face which extends parallel to the longitudinal axis, the proximal wire segment having a first elasticity; a distal wire segment having a proximal end, a distal end and a longitudinal axis extending therebetween, the proximal end being formed with a second flat planar bonding face which extends parallel to the longitudinal axis, the distal wire segment having a second elasticity; wherein the first and second flat planar bonding faces of the proximal wire segment are formed complementary to one another; and further wherein the proximal and distal wire segments are joined together by bonding the first flat planar bonding face to the second flat planar bonding face in an overlapping manner and a method for forming a composite guidewire.

Abstract: A method of producing a bonded structure which includes a layer of material capable of forming a diffusion or diffusion-type bond with diamond bonded to a diamond element. The method includes the step of applying electron beam heating to a localised region of contacting surfaces between the diamond and the layer of material, or the layer of material and a surface of a metal element or structure to cause bonding of at least some of the contacting surfaces in that region. The method has particular application to the bonding of a layer of diamond to a frame or mount.

Abstract: A layer of single crystal CVD diamond of high quality having a thickness greater than 2 mm. Also provided is a method of producing such a CVD diamond layer.

Abstract: A layer of single crystal boron doped diamond produced by CVD and having a total boron concentration which is uniform. The layer is formed from a single growth sector, or has a thickness exceeding 100 ?m, or has a volume exceeding 1 mm3, or a combination of such characteristics.

Abstract: A method of detecting radiation that includes providing a layer of high purity single crystal CVD diamond, applying an electric field of no greater than 0.5 V/?m to the layer, exposing the layer to the radiation thereby generating a signal, and detecting the signal.

Abstract: The present invention relates to an improved process for the preparation of heterocyclyl substituted adenosine derivatives. More particularly the invention is concerned with preparation of particular physical forms of (2S, 3S, 4R, 5R)-2-(5 tert-butyl-[1,3,4]oxadiazol-2-yl)-5-[6-(4-chloro-2-fluoro-phenylamino)-9H-purin-9-yl]tetrahydro-furan-3, 4-diol.

Abstract: A process of making a product which comprises at least two layers in contact with each other, each layer being of a wide-gap material and each layer differing from each other in at least one property, includes the steps of: (i) providing a substrate of a wide-band gap material having a surface and a region adjacent the surface having a particular characteristic, (ii) ion implanting the substrate through the surface to form a damaged layer below that surface, (iii) growing a layer of a wide-band gap material by chemical vapour deposition on at least a portion of the surface of the substrate through which ion implantation occurred, the material of the grown layer having a characteristic different to that of the region of the substrate adjacent the surface through which ion implantation occurred, and (iv) severing the substrate through the damaged layer. The wide-gap material is preferably diamond.