Abstract: The present disclosure provides methods of treating polycystic ovary syndrome (PCOS) with tetrahydro-iso-alpha acid (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof, in particular KDT500 and KDT501.

Abstract: A method includes receiving an utterance at a computerized automated assistant system, and detecting, via a date/time constraint module of the computerized automated assistant system, one or more constraints in the utterance associated with a date or time. The utterance is associated with a domain. The method further comprises generating, via the date/time constraint module, a periodic set for each of the one or more constraints associated with the date or time, and combining, via the date/time constraint module, the one or more periodic sets. The method further comprises processing, via a dialogue manager module of the computerized automated assistant system, the combined periodic sets to determine an action, and executing the action at the computerized automated assistant system.

Abstract: A method for a dialogue system includes establishing a dialogue session between an application executing on a server and a remote machine. The dialogue session includes one or more utterances received from a user at the remote machine. A natural language processing machine identifies a request associated with a computer-readable representation of an utterance. A dialogue expansion machine generates a plurality of alternative actions for responding to the request. A previously-trained machine learning confidence model assesses a confidence score for each alternative. If a highest confidence score for a top alternative does not satisfy a threshold, the plurality of alternatives including the top alternative are transmitted to a remote machine (which may be the same remote machine or a different remote machine) for review by a human reviewer. After the dialogue system and/or the human reviewer select an alternative, computer-readable instructions defining the selected alternative are executed.

Abstract: The present invention provides a Cas9 platform to facilitate single-site nuclease gene editing precision within a human genome. For example, a Cas9 nuclease/DNA-targeting unit (Cas9-DTU) fusion protein precisely delivers a Cas9/sgRNA complex to a specific target site within the genome for subsequent sgRNA-dependent cleavage of an adjacent target sequence. Alternatively, attenuating Cas9 binding using mutations to the a protospacer adjacent motif (PAM) recognition domain makes Cas9 target site recognition dependent on the associated DTU, all while retaining Cas9's sgRNA-mediated DNA cleavage fidelity. Cas9-DTU fusion proteins have improved target site binding precision, greater nuclease activity, and a broader sequence targeting range than standard Cas9 systems. Existing Cas9 or sgRNA variants (e.g., truncated sgRNAs (tru-gRNAs), nickases and FokI fusions) are compatible with these improvements to further reduce off-target cleavage.

Abstract: Examples of maintaining or querying a traffic database to generate a traffic flow model to provide traffic flow information and determine a per-lane route for a vehicle to travel are disclosed.

Abstract: The present invention includes a process for producing treated filler that includes (a) treating a slurry that includes untreated filler where the untreated filler has not been previously dried, with a treating composition that includes a treating agent, thereby forming a treated filler slurry, and (b) drying the treated filler slurry to produce treated filler. The treating agent can include an unsaturated fatty acid, derivative of an unsaturated fatty acid, or salt thereof. The present invention also is directed to treated filler prepared by the process, as well as rubber compounding compositions and tires including the treated filler.

Abstract: A population activity mapping method may include detecting a plurality of wireless mobile devices within a geographic region. Individual wireless mobile devices may include a processor, a user interface, a transmitter and a receiver. The detecting operation may be performed by use of a wireless access point, a GPS satellite, and/or a base station, and may be performed at at least two different points in time. Input data may be provided based upon the detecting operation. A distance and speed at which the mobile devices travel within the geographic region may be discerned dependent upon the input data. The discerning operation is performed by at least one processor of a computer network. A time and/or location at which salable output is to be made available and/or an amount of salable output to be made available may be determined dependent upon the discerning operation.

Abstract: Examples of maintaining or querying a traffic database to generate a traffic flow model to provide traffic flow information and determine a per-lane route for a vehicle to travel are disclosed.

Abstract: Techniques are generally described related to management of power consumption for a processor. One example method may include identifying a target operating constraint and a first operating parameter; determining a second operating parameter based on the target operating constraint and the first operating parameter; estimating an actual operating constraint; comparing the target operating constraint and the actual operating constraint; and setting up the first operating parameter and the second operating parameter of the processor based on a comparison of the target operating constraint and the actual operating constraint, wherein the target operating constraint is not a worst-case operating constraint. Other examples of methods, systems, and computer programs related to managing power consumption for a processor are also contemplated.

Abstract: A population activity mapping method may include detecting a plurality of wireless mobile devices within a geographic region. Individual wireless mobile devices may include a processor, a user interface, a transmitter and a receiver. The detecting operation may be performed by use of a wireless access point, a GPS satellite, and/or a base station, and may be performed at least two different points in time. Input data may be provided based upon the detecting operation. A distance and speed at which the mobile devices travel within the geographic region may be discerned dependent upon the input data. The discerning operation is performed by at least one processor of a computer network. A time and/or location at which salable output is to be made available and/or an amount of salable output to be made available may be determined dependent upon the discerning operation.

Abstract: A rotary surface cleaning machine for cleaning floors, including both carpeted floors and uncarpeted hard floor surfaces including but not limited to wood, tile, linoleum and natural stone flooring. The rotary surface cleaning machine has a rotary surface cleaning tool mounted on a frame and coupled for high speed rotary motion relative to the frame. The rotary surface cleaning tool has a substantially circular operational surface that performs the cleaning operation. The rotary surface cleaning tool is driven by an on-board power plant to rotate at high speed. The rotary surface cleaning tool is coupled to a supply of pressurized hot liquid solution of cleaning fluid and a powerful vacuum suction source.

Abstract: Techniques are generally described for mapping a thread onto heterogeneous processor cores. Example techniques may include associating the thread with one or more predefined execution characteristics, assigning the thread to one or more heterogeneous processor cores based on the one or more predefined execution characteristics, and/or executing the thread by the respective assigned heterogeneous processor cores.

Abstract: Techniques described herein generally relate to multi-core processors including two or more processor cores. Example embodiments may set forth devices, methods, and computer programs related to calculating a clock rate for one or more of the processor cores in the multi-core processor. One example method may include determining a first estimated workload for a first processor core and a second estimated workload for a second processor core within a scheduling interval in a periodic scheduling environment. In addition, a first clock rate for the first processor core may be calculated based on one or more of the first estimated workload, a maximum clock rate supported by the multi-core processor and/or the scheduling interval. Similarly, a second clock rate for the second processor core may also be calculated based on one or more of the second estimated workload, the maximum clock rate, and/or the scheduling interval.

Abstract: Techniques for cloud data backup are disclosed. Example methods may store backup data from a client computer on portions of data storage media associated with peer computers. In some example embodiments, a tile ma be encoded into segments using an error-tolerant encoding scheme, and the segments may be stored on peer computers. In some example embodiments, individual segments may be stored on more than one peer machine and/or an individual peer machine may not receive all of the segments associated with the file.

Abstract: A rotary surface cleaning machine for cleaning floors, including both carpeted floors and uncarpeted hard floor surfaces including but not limited to wood, tile, linoleum and natural stone flooring. The rotary surface cleaning machine has a rotary surface cleaning tool mounted on a frame and coupled for high speed rotary motion relative to the frame. The rotary surface cleaning tool has a substantially circular operational surface that performs the cleaning operation. The rotary surface cleaning tool is driven by an on-board power plant to rotate at high speed. The rotary surface cleaning tool is coupled to a supply of pressurized hot liquid solution of cleaning fluid and a powerful vacuum suction source.

Abstract: The present invention provides a Cas9 platform to facilitate single-site nuclease gene editing precision within a human genome. For example, a Cas9 nuclease/DNA-targeting unit (Cas9-DTU) fusion protein precisely delivers a Cas9/sgRNA complex to a specific target site within the genome for subsequent sgRNA-dependent cleavage of an adjacent target sequence. Alternatively, attenuating Cas9 binding using mutations to the a protospacer adjacent motif (PAM) recognition domain makes Cas9 target site recognition dependent on the associated DTU, all while retaining Cas9's sgRNA-mediated DNA cleavage fidelity. Cas9-DTU fusion proteins have improved target site binding precision, greater nuclease activity, and a broader sequence targeting range than standard Cas9 systems. Existing Cas9 or sgRNA variants (e.g., truncated sgRNAs (tru-gRNAs), nickases and FokI fusions) are compatible with these improvements to further reduce off-target cleavage.

Abstract: Techniques for cloud data backup are disclosed. Example methods may store backup data from a client computer on portions of data storage media associated with peer computers. In some example embodiments, a file may be encoded into segments using an error-tolerant encoding scheme, and the segments may be stored on peer computers. In some example embodiments, individual segments may be stored on more than one peer machine and/or an individual peer machine may not receive all of the segments associated with the file.

Abstract: An operating system sandbox may include an operating system isolation module configured to restrict an operating system from transmitting machine-readable data and/or machine-readable instructions to an application, based on at least one predefined rule corresponding to abnormal operating system behavior.

Abstract: A data center management system may include a processor coupled to a network. The network may be further coupled to a primary data center and a secondary data center located at a physical location remote from the primary data center. The processor may be adapted to execute computer implemented instructions to determine a first transition point for the primary data center with respect to a secondary data center on the basis of one or more financial indicators, transfer one or more data center tasks from the primary data center to the secondary data center at substantially the first transition point, and execute the one or more transferred data center tasks at the secondary data center.

Abstract: Techniques are generally described for a multi-core processor with a plurality of processor cores. At least one cache is accessible to at least two of the plurality of processor cores. The multi-core processor can be configured for separately allocating a memory space within the cache to the individual processor cores accessing the cache.