Abstract: Coronavirus Disease 2019 (COVID-19) remains a threat with the emergence of new variants, especially Delta and Omicron, without specific effective therapeutic drugs. The present invention provides a method and a composition for preventing and treating COVID-19 (SARS-CoV-2) coronavirus infection which includes administering to a subject in need thereof one or more therapeutically effective doses of Virofree which comprises a pharmaceutically acceptable combination of grape seed extract, acerola cherry extract, olive leaf extract, marigold extract, green tea extract, pomegranate extract, yeast beta-glucan and soya bean extract for a treatment period.

Abstract: A power mesh structure for an integrated circuit is provided. A power switch cell is installed on the chip of the integrated circuit to control the switching operations of the power domain. The power meshes of the power mesh structure is specially designed. The power wires with different electrical properties are arranged in the same column or the same row to reduce the layout area of the power mesh on the material layer.

Abstract: A multi-material printer for using multiple materials, e.g., bioinks, to quickly fabricate structures, such as high-throughput screening microfluidic chips. The printer’s light projector for emits light in an exposure sequence to cure material in an additive manufacturing process. The printer further includes a motion stage operable to move a build platform into and out of the reservoir in coordination with the exposure sequence. The printer further includes an indexing stage having a work table for supporting the reservoir. The indexing stage is operable to selectively align the build platform with multiple different materials of the reservoir. The multiple materials may be arranged at distinct angular positions within a single reservoir, and the indexing stage may be operable to rotate the work table to align the build platform with different materials during the exposure sequence for a quick transition among different materials without refilling of materials, exchange of reservoirs, etc.

Abstract: The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-VSIG4 compositions for therapeutic, diagnostic, prognostic, and screening purposes.

Abstract: In some embodiments, a reconstitution or medicinal fluid delivery device includes a transfer engine including two fluidly connected spikes, each configured to pierce a container. A check valve may be disposed between the two spikes to allow unidirectional flow from one container to the other. Physical access to a fluid outlet may be obstructed by a housing until the reconstitution or medicinal fluid delivery device is actuated, whereupon physical access to the fluid outlet is permitted. The reconstitution or medicinal fluid delivery device may be placed on a flat surface and actuated with force applied in a single direction toward the flat surface.

Abstract: Apparatuses (e.g., devices, systems, etc.) and methods that may provide access to one or more tools to a remote site in the body including expandable and external working channels that may be part of a tube that is coupled to an outer surface of an elongate medical device, such as an endoscope.

Abstract: In one embodiment, at least a processing chamber includes a perforated lid, a gas blocker disposed on the perforated lid, and a substrate support disposed below the perforated lid. The gas blocker includes a gas manifold, a central gas channel formed in the gas manifold, a first gas distribution plate comprising an inner and outer trenches surrounding the central gas channel, a first and second gas channels formed in the gas manifold, the first gas channel is in fluid communication with a first gas source and the inner trench, and the second gas channel is in fluid communication with the first gas source and the outer trench, a second gas distribution plate, a third gas distribution plate disposed below the second gas distribution plate, and a plurality of pass-through channels disposed between the second gas distribution plate and the third gas distribution plate.

Abstract: Softgel capsules have a fill composition that administers a 200 to 500 mg dose of magnesium from magnesium oxide and an outer sofgel gelatin shell. The composition includes 55 to 70% w/w of an edible oil, 2 to 8% w/w polysorbate 80, 0.5 to 2% w/w hydrophobic silica, and 0.2 to 4% w/w of a chelating agent for binding to magnesium. The softgel capsules have a dissolution according to USP <711> of greater than NLT 75% (Q).

Abstract: The invention presents a system and a method for 3D human reconstruction using a compact kit of depth cameras. Instead of using complex and expensive devices as in traditional methods, the proposed system and method employs a simple, easy-to-install system to accurately collect the human body shape. The generated model is capable of moving thanks to a skeleton system simulating the human skeleton. The proposed system includes four blocks: Data Collection Block, Point Cloud Standardization Block, Human Digitization Block and Output Block. The proposed method includes five steps: Point Cloud Collecting, Point Cloud Filtering, Point Cloud Calibrating, Point Cloud Optimizing and 3D Human Model Generating.

Abstract: Techniques are disclosed relating to automatically generating and analyzing database queries. In various embodiments, a database inquiry assistance system maintains a first machine learning model trained using query history data for a database and a second machine learning model using analysis history for the database. In an embodiment, the system receives from a user system a request for an inquiry into data stored in the database and identifies a sequence of queries for responding to the request, where identifying the sequence of queries includes applying the second machine learning model to the request. The system generates corresponding database query code for implementing one or more of the queries in the sequence of queries, where generating the corresponding database query code includes applying the first machine learning model to descriptors of one or more of the queries, and sends a plan identifying the sequence of queries to the user system.

Abstract: The present invention relates to a method for detecting inflammation-related platelet activation, comprising measuring the quantity, concentration and/or the proportion of seven specific biomarkers representative of 47 intra-platelet, soluble and membrane molecules, in a biological sample. Said panel of seven biomarkers is particularly useful for implementing a method of diagnosing inflammation-related platelet activation in an individual, a method for monitoring the efficacy of a curative or preventive treatment of an inflammatory disease in an individual and/or a method for monitoring the development of an inflammatory disease associated with inflammation-related platelet activation in an individual. The present invention also relates to a kit for detecting inflammation-related platelet activation, as well as the use thereof.

Abstract: One of the biggest challenges for all renewable energy sources (RES) is that they are variable power generators which will require reactive power or energy storage systems (ESS) to provide reliable power quality (ideally power factor of one) at the power grid generation side. The present invention is directed to a power packet network (PPN) for integrating wave energy converter (WEC) arrays into microgrids. Specifically, an array of WECs can be physically positioned such that the incoming regular waves will produce an output emulating an N-phase AC system such that the PPN output power is constant. ESS requirements are thereby minimized whilst maintaining grid stability with high power quality. This will enable RES integration onto a future smart grid for large-scale adoption and cost reduction while preserving high efficiency, reliability, and resiliency.

Abstract: One of the biggest challenges for all renewable energy sources (RES) is that they are variable power generators which will require reactive power or energy storage systems (ESS) to provide reliable power quality (ideally power factor of one) at the power grid generation side. The present invention is directed to a power packet network (PPN) for integrating wave energy converter (WEC) arrays into microgrids. Specifically, an array of WECs can be physically positioned such that the incoming regular waves will produce an output emulating an N-phase AC system such that the PPN output power is constant. ESS requirements are thereby minimized whilst maintaining grid stability with high power quality. This will enable RES integration onto a future smart grid for large-scale adoption and cost reduction while preserving high efficiency, reliability, and resiliency.

Abstract: The invention provides an inertial sensing device the capability to achieve self-alignment (sensor error compensation), by using dual-rotation modulation technique. The self-alignment process is performed based on fully building the sensor's mathematical model and rotating the inertial sensor blocks in a specific order. The advantages of this technology are fast calibration time, high accuracy, and the ability to separate independent movements on the axes of the inertial sensor. The inertial sensor based on a dual-rotation modulation platform is applied to marine and aeronautical fields.

Abstract: Exemplary methods of treating a chamber may include delivering a cleaning precursor to a remote plasma unit. The methods may include forming a plasma of the cleaning precursor. The methods may include delivering plasma effluents of the cleaning precursor to a processing region of a semiconductor processing chamber. The processing region may be defined by one or more chamber components. The one or more chamber components may include an oxide coating. The methods may include halting delivery of the plasma effluents. The methods may include treating the oxide coating with a hydrogen-containing material delivered to the processing region subsequent halting delivery of the plasma effluents.

Abstract: Embodiments of the disclosure relate to faceplates for a processing chamber. In one example, a faceplate includes a body having a plurality of apertures formed therethrough. A heating element is disposed within the body, and the heating element circumscribes the plurality of apertures. A support ring is disposed the body. The support ring circumscribes the heating element. The support ring includes a main body and a cantilever extending radially inward from the main body. The cantilever contacts the body of the faceplate.

Abstract: A rigidizing system includes an elongate rigidizing device configured to be rigidized by vacuum or pressure from a flexible configuration to a rigid configuration and an outer tube configured to be positioned around the rigidizing device. The outer tube includes a plurality of expandable channels therein configured to enable passage of a working tool therethrough.

Abstract: A method of queue design for data storage and management applies RAM data synchronization technology on many distributed nodes, both ensures storage performance and solves the problem of data loss in the system operation process; performs business separation and parallelize actions to optimize processing performance; uses simply extracted information instead of accessing the original information helps to speed up the processing ability and promptly detect events that exceed the threshold; allocates a fixed memory for the queue to ensure the safety of the whole system; in addition, provides monitoring and early warning of possible incidents. The method includes: step 1: build a deployment model; step 2: initialize the values when the application first launches; step 3: process write data to the queue; step 4: detect the threshold and process the data in the queue; step 5: remove processed data from the queue; step 6: monitor queue and early warn.

Abstract: Methods and systems are disclosed for quantizing images using machine-learning. A plurality of input images are received from a sensor (e.g., a camera), wherein each input image includes a plurality of pixels. Utilizing an image-to-image machine-learning model, each pixel is assigned a new pixel color. Utilizing a mixer machine-learning model, each new pixel color is converted to one of a fixed number of colors to produce a plurality of quantized images, with each quantized image corresponding to one of the input images. A loss function is determined based on an alignment of each input image with its corresponding quantized image via a pre-trained reference machine-learning model. One or more parameters of the image-to-image machine-learning model and the mixer model are updated based on the loss function. The process repeats, with each iteration updating the parameters of the image-to-image machine-learning model and the mixer model, until convergence, resulting in trained models.