Abstract: A package assembly includes a container that is configured for expansion in a generally vertical direction between a collapsed state and an extended state. The container includes a sidewall having a first axial end portion and an oppositely disposed second axial end portion. The sidewall is vertically compressed in the collapsed state and configured for expansion in a generally vertical direction to the extended state. A base portion is engaged with the first axial end portion of the sidewall. The base portion and the sidewall cooperatively define an interior region having an opening. A cover is engaged with the second axial end portion of the sidewall. The cover is configured for covering the opening to the interior region during cooking or heating.

Abstract: The invention provides an ink jet device and method for producing a biological assay substrate (41) by releasing a plurality of substances onto the substrate (41) The device comprises at least a print head and a plurality of substance containers (60, 61, 62) connectable thereto, and mounting means (55) for the containers, whereby at least part of the containers (60, 61, 62) is provided with identification means (63) The device further comprises reading means to read information contained in the identification means (63).

Abstract: The present invention relates to a method for depositing a substance on a support, comprising the provision of a substance solution, the provision of a transfer solution capable of activating the support, the deposition of the transfer solution on a predefined position of the support and the deposition of the substance solution on the same predefined position where the transfer solution was placed, whereby an immobilization of the deposited substance at the location of overlap between the deposited transfer solution and the deposited substance solution on said support is achieved. The present invention further relates to the use of a method for depositing a substance on a support for the manufacturing of a chip, a method for manufacturing a chip, wherein a substance is deposited on a chip substrate according to the method for depositing a substance on a support and a chip manufactured according to said method.

Abstract: An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.

Abstract: A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.

Abstract: The invention provides a porous biological assay substrate suitable for detecting at least one analyte in a biological sample fluid. The substrate comprises one or more capture probes able to each specifically bind one target analyte. The average concentration of the capture probes in pores with a size larger than the O50 of the substrate pore size distribution is at least equal to the average concentration of the capture probes in pores with a size smaller than the O50. The substrate thereby shows improved binding efficiency. The invention also relates to a method and device for producing the biological assay substrate, and to a method for examining analyte fluids using the substrate.

Abstract: An ingestible electronic capsule (100) for introduction into the bodily lumen comprises a circuit board with at least one electronic component (4,5,7,8,9,11, 12, 13, 14). The circuit board is formed from a flex foil (10), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule (100).

Abstract: A capsule and methodology for dispensing a medicament in the gastrointestinal tract of a mammal is disclosed, the gastrointestinal tract having tissue sites of interest. The capsule may include a medicament reservoir; medicament dispensing means such as a plurality of piezoelectric droplet jet nozzle dispensers; a power source; electronic control circuitry means and/or detecting means capable of communicating with a medicament dispensing means for regulating the amount and time interval for dispensing of the medicament into the gastrointestinal tract by the medicament dispensing means; and a non-digestible outer protective shell housing, e.g., the medicament reservoir, medicament dispensing means and electronic control circuitry means.

Abstract: A fluid sensor for use within the gastro-intestinal tract of a human being is disclosed. The sensor includes a sensing coil which is immersible in the sample fluid of the gastro-intestinal tract; a signal generator in electrical with the sensing coil for applying an electrical current pulse to the sensing coil; a signal receiver in communication with the sensing coil for measuring an electrical reflection relative to said electrical current pulse; and a data processor for receiving the electrical reflection and for calculating data representative of at least one property, such as pH of the sample fluid based on the electrical reflection. The fluid sensor can also include a reference coil for calibrating the sensing coil. The sensor coil and reference coil can be encapsulated in a swallowable pill shell. The sensor coil can also function as an antenna for transmitting and receiving signals to/form a remote location.

Abstract: A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.

Abstract: The invention provides an ink jet device for producing a biological assay substrate. The device releases a plurality of substances onto the substrate from print heads, provided with the substances. The device further comprises means to subject the printed substrates to an accelerated motion. The accelerated motion which acts about perpendicular to the surface of the substrates acts to control penetration of the substances into the substrate. The invention also relates to a method for producing a biological assay substrate, and to a biological assay substrate obtainable by such method.

Abstract: The invention provides an ink jet device for producing a biological assay substrate by releasing a plurality of substances onto the substrate, the device comprising at least a print head comprising a nozzle, the device comprising at least a transducer provided to eject a droplet out of the nozzle, wherein a detection means is assigned to the ink jet device such that the state of the print head can be monitored by means of the detection of the behaviour of to the transducer.

Abstract: This invention provides a biosensor solid or hydrogel substrate comprising one or more temperature indicating agents, each of said one or more temperature indicating agents operating by changing its optical properties and being deposited in and/or at the surface of the biosensor solid or hydrogel substrate as one or more layers and/or spots

Abstract: The invention relates to a printer device for producing biological test arrays by depositing an array of biofluids onto a substrate. The invention further relates to the use of such a device in the production of biological test arrays. The invention also relates to a method for producing a biological test array. The invention moreover relates to a biological test array. The method according to the invention is failure-proof, and results in biological test arrays of superior quality.

Abstract: The invention provides an ink jet device for releasing a plurality of substances onto a substrate, the device comprising at least one print head, which is positionable relative to the substrate, and which comprises at least one nozzle, provided to eject a droplet. The ink jet device is designed such that the plurality of substances can be deposited onto the substrate in a predefined pattern in a limited amount of moves of the at least one print head relative to the substrate.

Abstract: The invention provides an ink jet device for releasing controllably a plurality of substances onto a substrate, the device comprising at least a print head comprising a nozzle, the device comprising at least a transducer provided to eject a droplet out of the nozzle, wherein a detection means is assigned to the ink jet device such that the substances are discriminable from each other by means of the detection of the behaviour of the transducer.

Abstract: The invention provides an ink jet device (10) for producing a biological assay-substrate by releasing a plurality of substances onto the substrate, the device comprising printing means (20), detection means (30,32,45,45?), filling means and cleaning means (120), and wherein the ink jet device further comprises control means for an automated production such that the production of the biological assay substrate is error tolerant for a multitude of error sources.

Abstract: The invention provides an ink jet device for the controlled positioning of droplets of a substance onto a substrate, the device comprising at least a print head with a nozzle designed to eject the droplet, the device further comprising at least one acoustic sensor arranged for detecting the landing of the droplet on the substrate. A feedback loop stops the printing process the moment the landing of a droplet is not detected within a predetermined delay time.

Abstract: The invention provides a device for the controlled positioning of droplets of a substance onto a substrate, the device comprising at least a print head comprising a nozzle provided to eject the droplet, the inkjet device further comprising a control camera arranged such that after ejection of the droplet out of the nozzle, the droplet is detected by the control camera. In case either the droplet volume or velocity or flight path or viscosity or surface tension start to deviate from preset values, the software can correct for this in a closed loop manner. If the droplet is not ejected at all, the control software stops the printer and an operator can maintain the print head.

Abstract: An imprintable medium dispenser includes a chamber, a nozzle, and an actuator connected to the chamber and configured to be actuated and thereby generate a pressure wave within the chamber such that imprintable medium is dispensed from the nozzle. The imprintable medium dispenser is provided with a control circuit which includes a monitoring apparatus configured to receive a transient oscillation signal generated when the actuator is actuated, and to monitor the operation of the imprintable medium dispenser by monitoring the transient oscillation signal.