Patents by Inventor Annette Tobia

Annette Tobia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fructoseamine 3 kinase and the formation of collagen and elastin
    Publication number: 20070065443
    Abstract: The invention relates to the discovery that levels of collagen and elastin can be modulated by changing the flux through the Amadori Pathway and that copper containing compounds and complexes inhibit the enzyme fructoseamine-3-kinase.
    Type: Application
    Filed: August 4, 2006
    Publication date: March 22, 2007
    Inventors: Annette Tobia, Francis Kappler, Michael Schwartz
  • Treatment of inflammatory conditions
    Publication number: 20070021357
    Abstract: The invention relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.
    Type: Application
    Filed: June 16, 2006
    Publication date: January 25, 2007
    Inventors: Annette Tobia, Francis Kappler
  • Dermal delivery of n-methyl-glucamine and n-methyl-glucamine compounds
    Publication number: 20060110439
    Abstract: The present invention relates to methods and compositions for the treatment of skin-related conditions and disorders. In one aspect, the invention features methods and compositions for the transdermal delivery of compounds for the treatment of skin-related conditions and disorders, wherein the compositions include meglumine and a liposome component.
    Type: Application
    Filed: October 21, 2005
    Publication date: May 25, 2006
    Inventors: Annette Tobia, Francis Kappler
  • 3-deoxyglucosone and skin
    Publication number: 20050159383
    Abstract: The invention relates to the discovery that 3-deoxyglucosone (3DG) and other alpha-dicarbonyl sugars associated diseases and disorders are present and produced in the skin. Further, the invention relates to the discovery that amadorase, an enzyme that mediates 3DG synthesis, is also present in the skin. Thus, the invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.
    Type: Application
    Filed: October 15, 2004
    Publication date: July 21, 2005
    Inventors: Annette Tobia, Francis Kappler
  • 3-deoxyglucosone and skin
    Publication number: 20030219440
    Abstract: The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.
    Type: Application
    Filed: July 18, 2002
    Publication date: November 27, 2003
    Inventors: Annette Tobia, Francis Kappler