Abstract: A shoe (and fabrication techniques therefor) on which is provided a bottom portion that includes a sole portion and a heel portion and that has a bottom surface and an upper portion extending upwardly from the bottom portion. The bottom surface of the bottom portion of the shoe has areas of a fabric material (such as cotton, nylon, polyester, any other cloth or fabric), or any of a variety of other first materials, interspersed with areas of a durable material (such as ethylene vinyl acetate, polyvinyl chloride, thermoplastic rubber, any other plastic, and/or any other natural or synthetic leather or rubber), or any of a variety of other second materials.

Abstract: An apparatus to retain and position tubing of media bags with a bottom gate made of a single piece, with features to hold and retain media bag tubing, a recessed structure where the bottom gate is positioned when installed that places the top of the gate flush with the inside surface of the media bag holder, and locking tabs on the inside surface of the media bag holder that prevent the bottom gate from lifting and allow it to be installed in only the correct orientation.

Abstract: A shoe (and fabrication techniques therefor) on which is provided a bottom portion that includes a sole portion and a heel portion and that has a bottom surface and an upper portion extending upwardly from the bottom portion. The bottom surface of the bottom portion of the shoe has areas of a fabric material (such as cotton, nylon, polyester, any other cloth or fabric), or any of a variety of other first materials, interspersed with areas of a durable material (such as ethylene vinyl acetate, polyvinyl chloride, thermoplastic rubber, any other plastic, and/or any other natural or synthetic leather or rubber), or any of a variety of other second materials.

Abstract: A closure is provided for use with a dispensing device which comprises a housing having a dispensing outlet, a supply of a substance and a dispensing member mountable in the housing in a rest position relative to the housing and movable from the rest position to an actuated position, said movement from the rest position to the actuated position causing dispensing of said substance out of the dispensing outlet. The closure is adapted to close the dispensing outlet in two different orientations of the closure. Moreover, the closure has a restricting member which, when the closure closes the dispensing outlet in either orientation, prevents movement of the dispensing member from the rest position to the actuated position so that dispensing of the substance is prevented when the closure closes the dispensing outlet.

Abstract: A computer implemented method of searching genetic data or information for a plurality of query sequences in a set of target sequence fragments, allowing for mismatches at up to n sequence positions, including dividing each query sequence of the plurality of query sequences into n+1 query sequence segments and dividing each target fragment of the target sequence fragments into at least n+1 target sequence fragment segments, for each query sequence, constructing a first query group and a second query group by distributing query sequence segments there between such that at least n query sequence segments are contained in the second query group, constructing from each target fragment a first target group having a same distribution as the first query group, and for each query sequence, comparing the first query group with each first target group to identify potential matching target fragments.

Abstract: An inhaler is provided with a restricting member to prevent unintentional actuation of the inhaler. Also provided is an inhaler with an extensible strap joining a dust cap to the housing of an inhaler, the strap being particularly suited for use with inhalers that comprise a restricting member. The inhaler is useful, for example, in the treatment of asthma.

Abstract: An analytical system is provided for determining nitrogen monoxide, nitrogen dioxide and ozone concentrations in air samples. An ultraviolet light source 4 is used to alter the equilibrium between nitrogen dioxide and oxygen on the one hand and nitrogen monoxide and ozone on the other. Dynamic measurement of ozone concentration with time while ultraviolet irradiation is pulsed enables each gas concentration to be calculated without requiring input gases to be scrubbed. An aApparatus 101 is further provided to provide a controlled flow of gas to a sensor 103 attached to a high altitude balloon while sheltering it from the elements and allowing for affects of temperature, said apparatus comprising a shield 104 and a gas conducting means which uses the venturi effect to control air flow or has a hole to allow water to drain without affecting air flow past the sensor.

Abstract: A shoe (and fabrication techniques therefor) on which is provided a bottom portion that includes a sole portion and a heel portion and that has a bottom surface and an upper portion extending upwardly from the bottom portion. The bottom surface of the bottom portion of the shoe has areas of a fabric material (such as cotton, nylon, polyester, any other cloth or fabric), or any of a variety of other first materials, interspersed with areas of a durable material (such as ethylene vinyl acetate, polyvinyl chloride, thermoplastic rubber, any other plastic, and/or any other natural or synthetic leather or rubber), or any of a variety of other second materials.

Abstract: This disclosure is directed to the field of polynucleotide synthesis, and the embodiments taught herein are generally directed to a kit for use in the design of a desired polynucleotide from information obtained from a polypeptide or another polynucleotide, the generation of a custom set of oligonucleotides that complement the design, and the ordering of the custom set of oligonucleotides. The invention includes systems and methods for producing a desired polynucleotide using the kit.

Abstract: A shoe (and fabrication techniques therefor) on which is provided a bottom portion that includes a sole portion and a heel portion and that has a bottom surface and an upper portion extending upwardly from the bottom portion. The bottom surface of the bottom portion of the shoe has areas of a fabric material (such as cotton, nylon, polyester, any other cloth or fabric), or any of a variety of other first materials, interspersed with areas of a durable material (such as ethylene vinyl acetate, polyvinyl chloride, thermoplastic rubber, any other plastic, and/or any other natural or synthetic leather or rubber), or any of a variety of other second materials.

Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.

Abstract: Methods mediated by single-stranded nucleic acid templates, including utilizing single-stranded nucleic acid templates to isolate nucleic acid fragments and to recombine nucleic acid fragments. Methods include polymerase and polymerase-free recombination of nucleic acid fragments to generate chimeric nucleic acid sequences. Integrated systems and kits are also provided.

Abstract: A saddle for a bicycle, tricycle, exercise cycle or the like has a mounting arrangement which permits the saddle to rock from side to side as a rider pedals the cycle. The rocking motion has an effective centre above the surface of the saddle and the saddle is resiliently biased so as to return to its central position when the cycle is not being ridden.

Abstract: A method and apparatus for coating a surface of a substrate using combustion chemical vapor deposition is disclosed. A chemical vapor deposition stream, composed of a coating precursor and a combustible medium, is directed toward a substrate and combusted to provide a reacted coating precursor in a gaseous plume. The plume is modified by exposing it to a shield prior to the plume contacting the surface of the substrate and depositing a coating thereon. The shield serves to control the coating thickness and material characteristics of the deposited material.

Abstract: An analytical system is provided for determining nitrogen monoxide, nitrogen dioxide and ozone concentrations in air samples. An ultraviolet light source 4 is used to alter the equilibrium between nitrogen dioxide and oxygen on the one hand and nitrogen monoxide and ozone on the other. Dynamic measurement of ozone concentration with time whilst ultraviolet irradiation is pulsed enables each gas concentration to be calculated without requiring input gases to be scrubbed. An aApparatus 101 is further provided to provide a controlled flow of gas to a sensor 103 attached to a high altitude balloon whilst sheltering it from the elements and allowing for affects of temperature, said apparatus comprising a shield 104 and a gas conducting means which uses the venturi effect to control air flow or has a hole to allow water to drain without affecting air flow past the sensor.

Abstract: A shoe (and fabrication techniques therefor) on which is provided a bottom portion that includes a sole portion and a heel portion and that has a bottom surface and an upper portion extending upwardly from the bottom portion. The bottom surface of the bottom portion of the shoe has areas of a fabric material (such as cotton, nylon, polyester, any other cloth or fabric), or any of a variety of other first materials, interspersed with areas of a durable material (such as ethylene vinyl acetate, polyvinyl chloride, thermoplastic rubber, any other plastic, and/or any other natural or synthetic leather or rubber), or any of a variety of other second materials.