Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).

Abstract: A fan assembly that can be used as a cooling fan or an air circulator. The fan assembly can provide the cooling and air circulation functions simultaneously or separately. The intensity of the cooling and/or air circulation can be individually controlled and directed. The fan assembly includes a base unit, a mounting frame rotatably coupled to the base unit, and a plurality of blower housings, each enclosing a fan and coupled to the mounting frame. The mounting frame is rotatable about an axis parallel to the support plane of the base. At least one of the blower housings is rotatably mounted to the mounting frame. The position of the blower housings can be adjusted through the manipulation of a positioning handle that is coupled to the rotatable blower housing.

Abstract: A brew chamber for a single serve filter package. The chamber includes a receptacle having an open top, configured and dimensioned to receive the package. A frame for supporting the receptacle for pivotal movement about a first axis between a vertical brew position and a forwardly inclined open position. A lid is supported on the frame for pivotal movement about a second axis between a raised position allowing access to the open top when the receptacle is in the open position, and a lowered position closing the open top when the receptacle is in the brew position. The receptacle is linked to the lid such that the receptacle is pivoted between the brew and open positions in response to movement of the lid between the lowered and raised positions.

Abstract: A pivot assembly that can be used with various appliances. The pivot assembly provides up to three degrees of freedom when positioning the appliance. The pivot may be used, for example, with a fan that is mounted on a base such that direction of the airflow generated can be adjusted about three coordinate axes by manipulating a single rotatable pivot mount. The fan assembly includes a base unit and an arm to which an appliance may be detachably coupled. The opposite end of the arm is provided with a spherical cap which is received by the base unit. Any adjustments to the positioning of the rotatable pivot mount are maintained by the friction within the rotatable pivot mount. Additionally, the pivot mount may include a pivot guide to restrict the degree of rotation about the pivot, thereby increasing stability.

Abstract: An appliance assembly that can provide multiple independently positionable appliances, such as fans. The appliance assembly includes a base support, a frame coupled to the base support, and a number of appliances each contained within an appliance housing. Each appliance housing is rotatably mounted to an outer gimbal such that it is rotatable about a first axis, and each outer gimbal is mounted to the frame such that it is rotatable about a second axis. The appliance assembly can provide two degrees of freedom for positioning each of the number of appliances. The frame, outer gimbals, and appliance housing can be formed in a variety of shapes. The appliance assembly can be used, for example, with any product where it is desirable to have multiple independently positionable assemblies, such as fans, speakers, microphones, lights, and heaters.

Abstract: A pivot assembly that can be used with various appliances. The pivot assembly provides up to three degrees of freedom when positioning the appliance. The pivot may be used, for example, with a fan that is mounted on a base such that direction of the airflow generated can be adjusted about three coordinate axes by manipulating a single rotatable pivot mount. The fan assembly includes a base unit and an arm to which an appliance may be detachably coupled. The opposite end of the arm is provided with a spherical cap which is received by the base unit. Any adjustments to the positioning of the rotatable pivot mount are maintained by the friction within the rotatable pivot mount. Additionally, the pivot mount may include a pivot guide to restrict the degree of rotation about the pivot, thereby increasing stability.

Abstract: A fan assembly that can be used as a cooling fan or an air circulator. The fan assembly can provide the cooling and air circulation functions simultaneously or separately. The intensity of the cooling and/or air circulation can be individually controlled and directed. The fan assembly includes a base unit, a mounting frame rotatably coupled to the base unit, and a plurality of blower housings, each enclosing a fan and coupled to the mounting frame. The mounting frame is rotatable about an axis parallel to the support plane of the base. At least one of the blower housings is rotatably mounted to the mounting frame. The position of the blower housings can be adjusted through the manipulation of a positioning handle that is coupled to the rotatable blower housing.

Abstract: A brew chamber for a single serve filter package. The chamber includes a receptacle having an open top, configured and dimensioned to receive the package. A frame for supporting the receptacle for pivotal movement about a first axis between a vertical brew position and a forwardly inclined open position. A lid is supported on the frame for pivotal movement about a second axis between a raised position allowing access to the open top when the receptacle is in the open position, and a lowered position closing the open top when the receptacle is in the brew position. The receptacle is linked to the lid such that the receptacle is pivoted between the brew and open positions in response to movement of the lid between the lowered and raised positions.

Abstract: A slider mounted CPP GMR or TMR read head sensor is protected from electrostatic discharge (ESD) damage and from noise and cross-talk from an adjacent write head by means of a balanced resistive/capacitative shunt. The shunt includes highly resistive interconnections between upper and lower shields of the read head and a grounded slider substrate and a low resistance interconnection between the lower pole piece of the write head and the substrate. The capacitances between the pole piece and the upper shield, the upper shield and the lower shield and the lower shield and the substrate are made equal by either forming the shields and pole piece with equal surface areas and separating them with dielectrics of equal thicknesses, or by keeping the ratio of area to insulator thicknesses equal.

Abstract: There are disclosed novel neuropeptide Y ligands having the general formula I Wherein the symbols W, A, D, R1, R2, R3, R4 are further defined in the description. Compounds of formula I are agonists and antagonists of neuropeptide Y, and are therefore useful as regulators.

Abstract: The present invention is directed to a caster assembly for supporting an object. The assembly includes a caster wheel, a support member rotatably supporting the wheel and first and second side support pieces mounted on the support member. The support member includes a base support surface for engaging and supporting a bottom surface of an object. The first side support piece includes a first support surface adapted to engage and support a first side surface of the object. The second side support piece includes a second support surface adapted to engage and support a second side surface of the object. At least one of the side support pieces is slidably mounted on the support member and is adapted to be moved relative to the other side support piece to permit adjustment of a distance between the between the first and second side support surfaces to accommodate objects of different widths.

Abstract: The present invention is directed to a caster assembly for supporting an object. The assembly includes a caster wheel, a support member rotatably supporting the wheel and first and second side support pieces mounted on the support member. The support member includes a base support surface for engaging and supporting a bottom surface of an object. The first side support piece includes a first support surface adapted to engage and support a first side surface of the object. The second side support piece includes a second support surface adapted to engage and support a second side surface of the object. At least one of the side support pieces is slidably mounted on the support member and is adapted to be moved relative to the other side support piece to permit adjustment of a distance between the between the first and second side support surfaces to accommodate objects of different widths.

Abstract: A system and method for prefabricating information pages is disclosed, in which the necessary steps to retrieve and package information requested by a user are preemptively performed by the computer system. When the user later makes an explicit request for information, the desired information can be immediately displayed to the user without the delays associated with contemporaneous retrieval and packaging of the information. The prefabrication system of the invention can be configured to automatically tune its processing to the changing conditions that exist in the computer system, which can be used to maximize use of available system resources. The present invention can be scalably deployed to perform coordinated prefabrication services on multiple, distributed computing nodes. In an embodiment, the invention is completely non-intrusive, in which no changes to existing application are required to implement prefabrication of pages.