Patents by Inventor Arthur J. Chirino

Arthur J. Chirino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimized Fc variants and methods for their generation
    Patent number: 8093357
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: January 10, 2012
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Patent number: 8093359
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: January 10, 2012
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen K. Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Patent number: 8039592
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 18, 2011
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen K. Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Method of treatment using adiponectin variants
    Patent number: 7749956
    Abstract: A method of treating a mammal with an adiponectin mediated disorder comprising administering a therapeutically effective amount of an adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: July 6, 2010
    Assignee: Xencor, Inc.
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
  • Adiponectin variants
    Patent number: 7709607
    Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: May 4, 2010
    Assignee: Xencor, Inc.
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
  • Pharmaceutical compositions of adiponectin variants and methods of storage
    Patent number: 7678886
    Abstract: A composition comprising an adiponectin variant at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant would aggregate after storage at 4° C. for one week in 10 mM PO4, 150 mM NaCl buffer.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: March 16, 2010
    Assignee: Xencor, Inc.
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
  • Optimized Fc variants and methods for their generation
    Patent number: 7662925
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: February 16, 2010
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Globular adiponectin variants
    Patent number: 7592423
    Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the adiponectin variant is not glycosylated, the adiponectin variant does not have residues 1-100 relative to human adiponectin, and wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: September 22, 2009
    Assignee: Xencor, Inc.
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
  • Optimized Fc Variants and Methods for Their Generation
    Publication number: 20090214526
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 29, 2007
    Publication date: August 27, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc Variants and Methods for Their Generation
    Publication number: 20090142340
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 29, 2007
    Publication date: June 4, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Publication number: 20090092599
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 9, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Publication number: 20090081208
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 26, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized FC Variants and Methods for Their Generation
    Publication number: 20090068175
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 29, 2007
    Publication date: March 12, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Publication number: 20090068177
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 12, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc Variants and Methods for Their Generation
    Publication number: 20080292621
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 29, 2007
    Publication date: November 27, 2008
    Applicant: Xencor, Inc,
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc Variants and Methods for Their Generation
    Publication number: 20080181890
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 31, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kokl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants
    Patent number: 7317091
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: January 8, 2008
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Protein based tumor necrosis factor-receptor variants for the treatment of TNF related disorders
    Patent number: 7144987
    Abstract: The invention relates to novel proteins with TNF-receptor antagonist activity and nucleic acids encoding these proteins. The invention further relates to TNF-receptor proteins with reduced immunogenicity and the use of these novel proteins in the treatment of TNF related disorders.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: December 5, 2006
    Assignee: Xencor
    Inventors: Arthur J. Chirino, Peizhi Luo, Peter Colon McDonnell, Umesh Muchhal, Malu Lourdes Tansey
  • Novel proteins with altered immunogenicity
    Publication number: 20040230380
    Abstract: The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties.
    Type: Application
    Filed: January 8, 2004
    Publication date: November 18, 2004
    Applicant: Xencor
    Inventors: Arthur J. Chirino, Bassil I. Dahiyat, John Rudolph Desjarlais, Shannon Alicia Marshall
  • Optimized Fc variants and methods for their generation
    Publication number: 20040132101
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: September 26, 2003
    Publication date: July 8, 2004
    Applicant: Xencor
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa