Abstract: A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z1-Z5 is independently H or halogen; R4 is H, OH, NH2, NHR8, NR8R9 or R8; R5, R6, and R7 is each independently H, halogen, OR8, R8, NHR8, NR8R9, CO2R8, CONR8R9, SO2NR8R9, or R5 and R6 together with the carbon atoms to which R5 and R6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R8 and R9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R8 and R9 together with the nitrogen t

Abstract: A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z1-Z5 is independently H or halogen; R4 is H, OH, NH2, NHR8, NR8R9 or R8; R5, R6, and R7 is each independently H, halogen, OR8, R8, NHR8, NR8R9, CO2R8, CONR8R9, SO2NR8R9, or R5 and R6 together with the carbon atoms to which R5 and R6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R8 and R9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R8 and R9 together with the nitrogen t

Abstract: A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z1-Z5 is independently H or halogen; R4 is H, OH, NH2, NHR8, NR8R9 or R8; R5, R6, and R7 is each independently H, halogen, OR8, R8, NHR8, NR8R9, CO2R8, CONR8R9, SO2NR8R9, or R5 and R6 together with the carbon atoms to which R5 and R6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R8 and R9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R8 and R9 together with the nitrogen t

Abstract: The present invention relates to a method for storage and subsequent lysis of a sample in which the sample is immobilized on a solid support. The solid matrix is embedded with a low concentration of both a chaotropic salt and a surfactant which act synergistically to efficiently store and lyse a biological sample.

Abstract: The present invention relates to a method for storage and subsequent lysis of a sample in which the sample is immobilized on a solid support. The solid matrix is embedded with a low concentration of both a chaotropic salt and a surfactant which act synergistically to efficiently store and lyse a biological sample.

Abstract: The present invention relates to a channel plate comprising a number of rows of units, at least one inlet and at least one outlet, at least one turning box, wherein turning boxes being connections between two adjacent rows of units in the channel plate, that fluid may flow from one row to the other in the created room. The present invention relates further to flow sections and flow module.

Abstract: The present invention relates to a multifunctional module comprising one or more units selected from the group consisting of reactor units, filter units, membrane units, reactor-separator units, clarificator units, purificator units, extractor units, and mixer units. The units are connected parallel or in series or both to each other, and each unit has at least one member having a surface, which surface is rotating with the member. The member is rotating around an axis making the unit operate under centrifugal force. One or more chambers for fluids are co-rotating with the rotating member. The present invention relates further to units which could be used in a spinning multifunctional module, and use of a spinning multifunctional module.

Abstract: The present invention relates to a method for storage and subsequent lysis of a sample in which the sample is immobilized on a solid support. The solid matrix is embedded with a low concentration of both a chaotropic salt and a surfactant which act synergistically to efficiently store and lyse a biological sample.

Abstract: A data processor at a central location includes, a central processing unit, a receiving component to receive prescriptions from dentists, a validation component to insure prescriptions are complete, accurate and comply with any legal or industry standards, an importer to write the prescriptions to a central database, a transmitting component to send the prescriptions to participating dental laboratories, a second receiving component to receive updates related to the production and delivery of the prescribed prostheses, a transmitting component to notify affected parties of changes to the production or delivery status of the prescribed prosthesis.

Abstract: A data processor at a central location includes a central processing unit, a receiving component to receive garnishments, an importer which writes the garnishments to a central database, a transmitting component which sends the garnishments to participating garnishees, a second receiving component to receive responses to garnishments, a validation component to insure the responses meet basic standards of compliance and completeness, a business rules engine within the validation component to apply jurisdiction-specific standards to the validation, a second importer which writes the garnishee responses to the central database, and a second transmitting component.

Abstract: A connector system for connecting first and second elongate conductors includes a wedge connector and a hydraulic power drive tool assembly. The wedge connector includes: a sleeve member defining a sleeve cavity and mountable on the first and second conductors; a wedge member; and a lubricant coating disposed on at least one of the sleeve member and the wedge member. The hydraulic power drive tool assembly is adapted to drive the wedge member into the sleeve cavity when the sleeve member is mounted on the first and second conductors to secure the wedge connector to each of the first and second conductors. According to some embodiments, the lubricant is a wax.

Abstract: The present invention relates to a channel plate comprising a number of rows of units, at least one inlet and at least one outlet, at least one turning box, wherein turning boxes being connections between two adjacent rows of units in the channel plate, that fluid may flow from one row to the other in the created room. The present invention relates further to flow sections and flow module.

Abstract: The present invention relates to a multipurpose flow module comprising flow plates and/or heat exchanger plates stacked together, which flow plate having a flow channel and one or more connection ports. To each flow plate or heat exchanger plate one or more barrier plates may be attached. The present invention further relates to a method for extraction, for reaction, for mixing, or combinations thereof in the multipurpose flow module, and to uses of the multipurpose flow module.

Abstract: The present invention relates to a multifunctional module comprising one or more units selected from the group consisting of reactor units, filter units, membrane units, reactor-separator units, clarificator units, purificator units, extractor units, and mixer units. The units are connected parallel or in series or both to each other, and each unit has at least one member having a surface, which surface is rotating with the member. The member is rotating around an axis making the unit operate under centrifugal force. One or more chambers for fluids are co-rotating with the rotating member. The present invention relates further to units which could be used in a spinning multifunctional module, and use of a spinning multifunctional module.

Abstract: An isolating apparatus for an electric power line includes an elongate insulator having opposed insulator ends and a pair of electrically conductive end members each secured to a respective one of the insulator ends. At least one of the end members includes a mounting slot that receives its respective one of the insulator ends.

Abstract: An electrical connector assembly includes a first conductive member and a second conductive member. The first conductive member includes a first channel portion extending from a first wedge portion, with the first channel portion configured to receive a first conductor therein. The first conductive member includes a jaw movably coupled to the first channel portion and being positioned between the first channel portion and the first wedge portion. The second conductive member includes a second channel portion extending from a second wedge portion where the second channel portion configured to receive a second conductor. The first wedge portion and the second wedge portion are assembled such that the second wedge portion engages the jaw and moves the jaw to the closed position. The jaw engages the first conductor in the closed position. Optionally, the first channel portion may have a contoured shape.

Abstract: An isolating apparatus for an electric power line includes an elongate insulator having opposed insulator ends and a pair of electrically conductive end members each secured to a respective one of the insulator ends. At least one of the end members includes a mounting slot that receives its respective one of the insulator ends.

Abstract: An electrical connector assembly includes a first conductive member and a second conductive member. The first conductive member includes a first channel portion extending from a first wedge portion, with the first channel portion configured to receive a first conductor therein. The first conductive member includes a jaw movably coupled to the first channel portion and being positioned between the first channel portion and the first wedge portion. The second conductive member includes a second channel portion extending from a second wedge portion where the second channel portion configured to receive a second conductor. The first wedge portion and the second wedge portion are assembled such that the second wedge portion engages the jaw and moves the jaw to the closed position. The jaw engages the first conductor in the closed position. Optionally, the first channel portion may have a contoured shape.

Abstract: The invention provides apparatus for cooling at least one sheave and/or an endless belt of a continuously variable transmission (CVT). As previously mentioned, the CVT is comprised of a drive clutch, a driven clutch, and the endless belt disposed about the drive and driven clutches. Both the drive and driven clutches include an axially stationary sheave and an axially movable sheave. Certain embodiments provide a ventilation air path through at least one sheave of at least one clutch of the CVT. In addition, certain embodiments provide a ventilation air path through both sheaves of at least one clutch of the CVT. Further, certain embodiments provide apparatus adapted to direct air proximate to an outer face of at least one sheave of at least one clutch inward to a central area of the at least one sheave when the at least one sheave is rotated in a direction of rotation.

Abstract: An electrical connector assembly for power utility transmission conductors includes a first conductive member having a tap conductor engagement surface adapted for interfacing with a tap conductor and a main conductor engagement surface adapted for interfacing with a main conductor. The first conductive member also includes a conductive member engagement surface adapted for interfacing with a second conductive member. The second conductive member is mechanically and electrically coupled to the first conductive member. The second conductive member has a tap conductor engagement surface adapted for interfacing with the tap conductor and a main conductor engagement surface adapted for interfacing with the main conductor. The second conductive member also includes a conductive member engagement surface adapted for interfacing with the conductive member engagement surface of the first conductive member.