Patents by Inventor Bastiaan Nuijen
Bastiaan Nuijen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220296637Abstract: Described herein is sodium thiosulfate (STS) for use in preventing or reducing hearing loss in patients receiving platinum-based drugs, for example as chemotherapy to treat cancer. The invention further relates to STS gel compositions suitable for administering to the middle ear of a patient in need thereof, particularly a patient receiving platinum-based drugs.Type: ApplicationFiled: June 19, 2020Publication date: September 22, 2022Inventors: Alfonsus Jacobus Maria BALM, Jacob Hendrik BEIJNEN, Bastiaan NUIJEN, Johannes Henricus Matthias SCHELLENS, Charlotte Louise ZUUR
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Patent number: 10322183Abstract: Ecteinascidin formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided.Type: GrantFiled: October 9, 2014Date of Patent: June 18, 2019Assignee: PHARMA MAR, S.A., SOCIEDAD UNIPERSONALInventors: Jacob Hendrik Beijnen, Bastiaan Nuijen, Pilar Calvo Salve, Maria Tobio Barreira
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Patent number: 9295666Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: GrantFiled: August 30, 2013Date of Patent: March 29, 2016Assignee: Spectrum Pharmaceuticals, Inc.Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Dorla Mirejovsky, Guru Reddy, Luigi Lenaz
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Publication number: 20150328180Abstract: Pharmaceutical compositions and methods for the treatment of neoplastic disease and comprising the combination of a taxane, such as docetaxel, with a CYP3A4 inhibitor, such as ritonavir. Methods of treatment of neoplastic disease incorporating the administration of a taxane and the administration of a CYP3A4 inhibitor, either simultaneously or separately, are also included. Further, kits for carrying out the methods are included. Solid pharmaceutical taxane compositions for oral administration comprising a substantially amorphous taxane, a carrier and a surfactant are also included.Type: ApplicationFiled: July 27, 2015Publication date: November 19, 2015Inventors: Jacob Hendrik Beijnen, Johannes Henricus Matthias Schellens, Johannes Moes, Bastiaan Nuijen
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Patent number: 9089544Abstract: Pharmaceutical compositions and methods for the treatment of neoplastic disease and comprising the combination of a taxane, such as docetaxel, with a CYP3A4 inhibitor, such as ritonavir. Methods of treatment of neoplastic disease incorporating the administration of a taxane and the administration of a CYP3A4 inhibitor, either simultaneously or separately, are also included. Further, kits for carrying out the methods are included. Solid pharmaceutical taxane compositions for oral administration comprising a substantially amorphous taxane, a carrier and a surfactant are also included.Type: GrantFiled: August 25, 2008Date of Patent: July 28, 2015Assignees: Slotervaart Participaties BV, Stichting Het Nederlands Kanker InstituutInventors: Jacob Hendrik Beijnen, Johannes Henricus Matthias Schellens, Johannes Jan Moes, Bastiaan Nuijen
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Publication number: 20150094313Abstract: Ecteinascidin formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided.Type: ApplicationFiled: October 9, 2014Publication date: April 2, 2015Inventors: Jacob Hendrik Beijnen, Bastiaan Nuijen, Pilar Calvo Salve, Maria Tobio Barreira
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Patent number: 8895557Abstract: Ecteinascidin formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided.Type: GrantFiled: October 28, 2005Date of Patent: November 25, 2014Assignee: Pharma Mar, S.A., Sociedad UnipersonalInventors: Jacob Hendrik Beijnen, Bastiaan Nuijen, Pilar Calvo Salve, Maria Tobio Barreira
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Publication number: 20140288143Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical administration of apaziquone immediately following transurethral resection. Also disclosed are therapeutic compositions comprising an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: ApplicationFiled: February 5, 2014Publication date: September 25, 2014Applicant: Spectrum Pharmaceuticals, Inc.Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Luigi Lenaz, Shanta Chawla, Mario Beer
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Publication number: 20140073680Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: ApplicationFiled: August 30, 2013Publication date: March 13, 2014Applicant: Spectrum Pharmaceuticals, Inc.Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Dorla Mirejovsky, Guru Reddy, Luigi Lenaz
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Patent number: 8648108Abstract: Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: GrantFiled: June 11, 2012Date of Patent: February 11, 2014Assignee: Spectrum Pharmaceuticals, Inc.Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijen
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Patent number: 8563592Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: GrantFiled: April 8, 2011Date of Patent: October 22, 2013Assignee: Spectrum Pharmaceuticals, Inc.Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Dorla Mirejovsky, Guru Reddy, Luigi Lenaz
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Patent number: 8420130Abstract: A stable pharmaceutical composition of a didemnin compound, comprises firstly a lyophilized didemnin preparation including water-soluble material and secondly a reconstitution solution of mixed solvents.Type: GrantFiled: February 18, 1999Date of Patent: April 16, 2013Assignee: Pharma Mar S.A.Inventors: Bastiaan Nuijen, Jacob Hendrik Beijnen, Roland Elizabeth Cornelis Henrar, Andres Gomez, Jose Jimeno
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Publication number: 20120252861Abstract: Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: ApplicationFiled: June 11, 2012Publication date: October 4, 2012Applicant: Spectrum Pharmaceuticals, Inc.Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen
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Publication number: 20110288472Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical administration of apaziquone immediately following transurethral resection. Also disclosed are therapeutic compositions comprising an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: ApplicationFiled: April 8, 2011Publication date: November 24, 2011Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Luigi Lenaz, Shanta Chawla, Mario Beer
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Publication number: 20110288143Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: ApplicationFiled: April 8, 2011Publication date: November 24, 2011Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Dorla Mirejovsky, Guru Reddy, Luigi Lenaz
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Publication number: 20110207804Abstract: Solid pharmaceutical taxane compositions for oral administration which comprise a substantially amorphous taxane, a carrier, and a surfactant, wherein the substantially amorphous taxane is prepared by a solvent evaporation method, such as spray drying. Methods of preparation of the composition and uses of the composition also are included.Type: ApplicationFiled: August 24, 2009Publication date: August 25, 2011Applicants: Slotervaart Participaties BV, Stichting Het Nederlands Kanker InstitutInventors: Jacob Hendrik Beijnen, Johannes Henricus Matthias Schellens, Johannes Moes, Bastiaan Nuijen
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Patent number: 7977369Abstract: Methods for treating bladder cancer comprising intravesicular administration of a stabilized pharmaceutical formulation comprising 5-(1-aziridinyl)-3-(hydroxymethyl)-2-[(E)-3-hydroxyprop-1-enyl]-1-methyl-1H-indole-4,7-dione (EO9). More specifically, the stabilized pharmaceutical formulation is instilled in the bladder for a time sufficient to treat the cancer.Type: GrantFiled: March 21, 2008Date of Patent: July 12, 2011Assignee: Spectrum Pharmaceuticals, Inc.Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen
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Publication number: 20090076123Abstract: Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.Type: ApplicationFiled: December 3, 2008Publication date: March 19, 2009Applicant: SPECTRUM PHARMACEUTICALS, INC.Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen
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Publication number: 20090054503Abstract: Pharmaceutical compositions and methods for the treatment of neoplastic disease and comprising the combination of a taxane, such as docetaxel, with a CYP3A4 inhibitor, such as ritonavir. Methods of treatment of neoplastic disease incorporating the administration of a taxane and the administration of a CYP3A4 inhibitor, either simultaneously or separately, are also included. Further, kits for carrying out the methods are included. Solid pharmaceutical taxane compositions for oral administration comprising a substantially amorphous taxane, a carrier and a surfactant are also included.Type: ApplicationFiled: August 25, 2008Publication date: February 26, 2009Applicants: SLOTERVAART PARTICIPATIES BV, VERENIGING HET NEDERLANDS KANKER INSTITUUTInventors: Jacob Hendrik BEIJNEN, Johannes Henricus Matthias SCHELLENS, Johannes MOES, Bastiaan NUIJEN
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Patent number: 7473681Abstract: Formulations and uses of kahalalide F.Type: GrantFiled: October 31, 2001Date of Patent: January 6, 2009Assignee: Pharma Mar, S.A.Inventors: Glynn Thomas Faircloth, Bastiaan Nuijen, Steve Weitman