Patents by Inventor Benjamin S. Bower

Benjamin S. Bower has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fungal genome modification systems and methods of use
    Patent number: 11427829
    Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: August 30, 2022
    Assignee: DANISCO US INC
    Inventors: Benjamin S. Bower, Jimmy Chan, Jing Ge, Xiaogang Gu, Susan Mampusti Madrid, Danfeng Song, Mingmin Song, Michael Ward
  • Fungal genome modification systems and methods of use
    Patent number: 11401522
    Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting modification of the DNA sequence at a target site in a fungal host cell genome.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: August 2, 2022
    Assignee: DANISCO US INC
    Inventors: Benjamin S. Bower, Jimmy Chan, Jing Ge, Xiaogang Gu, Susan Mampusti Madrid, Danfeng Song, Mingmin Song, Michael Ward, Steven Sungin Kim
  • COMPOSITIONS AND METHODS RELATED TO BETA-GLUCOSIDASE
    Publication number: 20200056216
    Abstract: The present compositions and methods relate to a beta-glucosidase from Glomerella graminicola, polynucleotides encoding the beta-glucosidase, and methods of making and/or use thereof. Formulations containing the beta-glucosidase may be suitable for use in hydrolyzing lignocellulosic biomass substrates.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 20, 2020
    Inventors: Benjamin S. Bower, Jimmy Chan, Meredith K. Fujdala, Thijs Kaper, Suzanne E. Lantz, Kirstin Y. Nose Crotty, Amr R. Toppozada
  • FUNGAL GENOME MODIFICATION SYSTEMS AND METHODS OF USE
    Publication number: 20180002710
    Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.
    Type: Application
    Filed: December 15, 2015
    Publication date: January 4, 2018
    Inventors: Benjamin S. Bower, Jimmy Chan, Jing Ge, Xiaogang Gu, Susan Mampusti Madrid, Danfeng Song, Mingmin Song, Michael Ward
  • Filamentous fungal host strains and DNA constructs, and methods of use thereof
    Patent number: 9701969
    Abstract: The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for efficiently screening DNA libraries encoding recombinant proteins.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: July 11, 2017
    Assignee: DANISCO US INC.
    Inventors: Benjamin S. Bower, Thijs Kaper, Bradley R. Kelemen
  • Cellulase variants with improved expression, activity and stability, and use thereof
    Patent number: 9523087
    Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: December 20, 2016
    Assignee: DANISCO US INC
    Inventors: Wolfgang Aehle, Richard R. Bott, Benjamin S. Bower, Jonathan Caspi, David A. Estell, Frits Goedegebuur, Ronaldus Wilhelmus Joannes Hommes, Thijs Kaper, Bradley R. Kelemen, Slavko Kralj, Johannes Franciscus Thomas Van Lieshout, Igor Nikolaev, Sander Van Stigt Thans, Louise Wallace, Gudrun Vogtentanz, Mats Sandgren
  • COMPOSITIONS COMPRISING A BETA-GLUCOSIDASE POLYPEPTIDE AND METHODS OF USE
    Publication number: 20160298157
    Abstract: The present compositions and methods relate to a beta-glucosidase from Melanocarpus albomyces, polynucleotides encoding the beta-glucosidase, and methods of making and/or using the same. Formulations containing the beta-glucosidase are suitable for use in numerous applications, including hydrolyzing lignocellulosic biomass substrates.
    Type: Application
    Filed: November 20, 2014
    Publication date: October 13, 2016
    Inventors: Benjamin S. BOWER, Jimmy CHAN, Meredith K. FUJDALA
  • Expression of granular starch hydrolyzing enzymes in trichoderma and process for producing glucose from granular starch sustrates
    Patent number: 9428780
    Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular starch substrate simultaneously with an alpha amylase and a GSHE at a temperature equal to or below the gelatinization temperature of the granular starch to obtain a composition of a glucose syrup.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: August 30, 2016
    Assignee: Danisco US Inc.
    Inventors: Toby M. Baldwin, Benjamin S. Bower, Gopal K. Chotani, Nigel Dunn-Coleman, Oreste J. Lantero, Suzanne Lantz, Michael J. Pepsin, Jayarama K. Shetty, Bruce A. Strohm
  • Expression of granular starch hydrolyzing enzyme in trichoderma
    Patent number: 9382563
    Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: July 5, 2016
    Assignee: DANISCO US INC.
    Inventors: Toby M. Baldwin, Benjamin S. Bower, Nigel Dunn-Coleman, Suzanne E. Lantz, Michael J. Pepsin
  • EXPRESSION OF GRANULAR STARCH HYDROLYZING ENZYMES IN TRICHODERMA AND PROCESS FOR PRODUCING GLUCOSE FROM GRANULAR STARCH SUSTRATES
    Publication number: 20150284756
    Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular starch substrate simultaneously with an alpha amylase and a GSHE at a temperature equal to or below the gelatinization temperature of the granular starch to obtain a composition of a glucose syrup.
    Type: Application
    Filed: April 16, 2015
    Publication date: October 8, 2015
    Applicant: DANISCO US INC.
    Inventors: Toby M. Baldwin, Benjamin S. Bower, Gopal K. Chotani, Nigel Dunn-Coleman, Oreste J. Lantero, Suzanne Lantz, Michael J. Pepsin, Jayarama K. Shetty, Bruce A. Strohm
  • BETA-GLUCOSIDASE FROM NEUROSPORA CRASSA
    Publication number: 20150252344
    Abstract: The present compositions and methods relate to a beta-glucosidase from Neurospora crassa, polynucleotides encoding the beta-glucosidase, and methods of make and/or use thereof. Formulations containing the beta-glucosidase are suitable for use in hydrolyzing lignocellulosic biomass substrates.
    Type: Application
    Filed: October 30, 2013
    Publication date: September 10, 2015
    Applicant: Danisco US Inc.
    Inventors: Benjamin S. Bower, Meredith K. Fujdala
  • COMPOSITIONS AND METHODS OF US
    Publication number: 20150252340
    Abstract: The present compositions and methods relate to a beta-glucosidase from Aspergillus terreus, polynucleotides encoding the beta-glucosidase, and methods of make and/or use thereof. Formulations containing the beta-glucosidase are suitable for use in hydrolyzing lignocellulosic biomass substrates.
    Type: Application
    Filed: October 30, 2013
    Publication date: September 10, 2015
    Applicant: DANISCO US INC.
    Inventors: Benjamin S. Bower, Meredith K. Fujdala
  • BETA-GLUCOSIDASE FROM MAGNAPORTHE GRISEA
    Publication number: 20150252343
    Abstract: The present compositions and methods relate to a beta-glucosidase from Magnaporthe grisea, polynucleotides encoding the beta-glucosidase, and methods of make and/or use thereof. Formulations containing the beta-glucosidase are suitable for use in hydrolyzing lignocellulosic biomass substrates.
    Type: Application
    Filed: October 30, 2013
    Publication date: September 10, 2015
    Applicant: DANISCO US INC.
    Inventors: Benjamin S. Bower, Meredith K. Fujdala
  • POLYPEPTIDES HAVING ALPHA-AMYLASE AND GRANULAR STARCH HYDROLYZING ACTIVITY
    Publication number: 20150093805
    Abstract: The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of Aspergillus niger.
    Type: Application
    Filed: December 1, 2014
    Publication date: April 2, 2015
    Applicant: DANISCO US INC.
    Inventors: Benjamin S. BOWER, Nigel DUNN-COLEMAN, Suzanne E. LANTZ, Cherry LIN, Michael WARD
  • Polypeptides having alpha-amylase and granular starch hydrolyzing activity
    Patent number: 8927250
    Abstract: The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of Aspergillus niger.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: January 6, 2015
    Assignee: Danisco US Inc.
    Inventors: Benjamin S. Bower, Nigel Dunn-Coleman, Suzanne E. Lantz, Cherry Lin, Michael Ward
  • CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF
    Publication number: 20140302585
    Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
    Type: Application
    Filed: February 25, 2014
    Publication date: October 9, 2014
    Applicant: DANISCO US INC.
    Inventors: Wolfgang AEHLE, Richard R. BOTT, Benjamin S. BOWER, Jonathan CASPI, David A. ESTELL, Frits GOEDEGEBUUR, Ronaldus Wilhelmus HOMMES, Thijs KAPER, Bradley R. KELEMEN, Slavko KRALJ, Johannes Franciscus Thomas VAN LIESHOUT, Igor NIKOLAEV, Sander VAN STIGT THANS, Louise WALLACE, Gudrun VOGTENTANZ, Mats SANDGREN
  • EXPRESSION OF GRANULAR STARCH HYDROLYZING ENZYME IN TRICHODERMA
    Publication number: 20140179007
    Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.
    Type: Application
    Filed: December 4, 2013
    Publication date: June 26, 2014
    Applicant: DANISCO US INC.
    Inventors: Toby M. BALDWIN, Benjamin S. BOWER, Nigel DUNN-COLEMAN, Suzanne E. LANTZ, Michael J. PEPSIN
  • Expression of granular starch hydrolyzing enzyme in
    Patent number: 8679815
    Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: March 25, 2014
    Assignee: Danisco US Inc.
    Inventors: Toby M. Baldwin, Benjamin S. Bower, Nigel Dunn-Coleman, Suzanne E. Lantz, Michael J. Pepsin
  • FILAMENTOUS FUNGAL HOST STRAINS AND DNA CONSTRUCTS, AND METHODS OF USE THEREOF
    Publication number: 20130149742
    Abstract: The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for achieving reliable expression of recombinant enzymes and variants.
    Type: Application
    Filed: June 3, 2011
    Publication date: June 13, 2013
    Applicant: Danisco US Inc.
    Inventors: Benjamin S. Bower, Thijs Kaper, Bradley R. Kelemen
  • Expression of granular starch hydrolyzing enzymes in and process for producing glucose from granular starch substrates
    Patent number: 8323932
    Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular starch substrate simultaneously with an alpha amylase and a GSHE at a temperature equal to or below the gelatinization temperature of the granular starch to obtain a composition of a glucose syrup.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 4, 2012
    Assignee: Danisco US Inc.
    Inventors: Toby M. Baldwin, Benjamin S. Bower, Gopal K. Chotani, Nigel Dunn-Coleman, Oreste J. Lantero, Jr., Suzanne E. Lantz, Michael J. Pepsin, Jayarama K. Shetty, Bruce A. Strohm