Abstract: A calibration device for the extrusion of profiles from plastics is provided. The calibration device comprises at least one tank calibrator with an opening and a running surface for the extruded profile, which can be arranged in a vacuum tank with cooling water and via whose outer surface the heat of the extruded profile can at least partly be transferred to the cooling water. The at least one tank calibrator includes at least one cooling channel for cooling the running surfaces and the axial length of the tank calibrator at least corresponds to the height and/or the width of the nominal dimension of the profile.

Abstract: A peptide is described, which consists of 7-17 adjacent amino acids and comprises the hexamer TXEXXE, wherein X, X and X can be any natural or non-natural amino acid, wherein the peptide has no TNF receptor binding activity and is cyclized, for the prevention and treatment of hyperpermeability of epithelial cells and endothelial cells.

Abstract: A heater includes a heater housing extending along a heater axis; a fuel cell stack assembly disposed within the heater housing and having a plurality of fuel cells which convert chemical energy from a fuel into heat and electricity through a chemical reaction with an oxidizing agent; a first medium conduit fixed relative to the heater housing and in fluid communication with the fuel cell stack assembly, the first medium conduit including a first medium conduit shelf extending laterally from the first medium conduit; a second medium conduit fixed relative to the heater housing and in fluid communication with the fuel cell stack assembly, the second medium conduit including a second medium conduit shelf extending laterally from the second medium conduit; wherein the fuel cell stack assembly is supported on the first medium conduit shelf and the second medium conduit shelf.

Abstract: Methods for treating inflammation include administering to a mammal in need thereof an effective amount of a treatment composition comprising a cyclized compound of the amino acid sequence of formula I: X1-GQRETPEGAEAKPWY-X2??(I) where X1 includes an amino acid sequence with 1 to 4 members having one or more natural or unnatural amino acids selected from: C, KSP, K, ornithin, 4-amino butanoic acid, ?-alanine, 6-amino-hexanoic acid, and 7-amino-heptanoic acid; where X2 is one natural amino acid selected from: C, D, G and E; and where prior to cyclization, X1 is the N-terminus and X2 is the C-terminus.

Abstract: A method for a logic circuit including a plurality of components and channels which are each assigned functional properties in a circuit model to simulate how the logic circuit functions, where the circuit model, in a section of the method, is expanded by mechanisms for security analysis, and where in a further section of the method, the following method steps are implemented via a simulation unit, i.e., check whether the security property of the respective component and/or the respective channel corresponds to the security requirement of the security-relevant data and generate a security risk report if it does not correspond thereto, apply a modeled attack to a component and/or to a channel, and determine a vulnerability of the security property of the respective component and/or of the respective channel to the applied attack, and if there is vulnerability of the security property, generate an attack report.

Abstract: A method is provided for computer-supported development of an overall system including subsystems. The subsystems include real products and virtual behavior models simulated in real-time, used in phases of the right branch of the V-model, including development steps “MIL,” “SIL” and “VPIL.” Each development step includes an environment model, a reusable multiphysics model and software. The development step “HIL” also includes another physics unit simulating parts of the hardware of a product that are only virtually present. The method provides a temporally parallel and spatially divided integration, and a corresponding test, of components on various levels (e.g., the right-hand branch of a V-model performed by the system developer). Open-loop and closed-loop control functions or processes for the overall system level may already be developed, even though all of the subsystems are not yet present. No parallel systems are required where new processes are run in advance.

Abstract: What is described is a peptide which consists of 7-20, especially 7-17, adjacent amino acids and comprises the hexamer TX1EX2X3E where X1, X2 and X3 may be any natural or unnatural amino acid, where the peptide does not have any TNF receptor binding activity and is cyclized, for use for the treatment and avoidance of the pulmonary form of altitude sickness.

Abstract: A method for determining system reliability of a logic circuit, wherein a functional component model for design/simulation of a circuit model of the logic circuit is created, where functional components model are expanded by adding an associated power model, a temperature model, and a reliability, where the logic circuit is constructed with expanded model components and, based on simulation of the logic circuit aided by the constructed circuit model, a functional, a power-dependent, and a temperature-dependent behavior and a temperature-dependent failure rate are derived for each component in a component specific manner for a specified application case, and where in addition to the functional behavior, a power and temperature behavior and a total failure rate can be determined simply and dynamically, based on the derived data and dependent on temperature and simulation time for the logic circuit for the specified application case.

Abstract: A heater includes a fuel cell stack assembly disposed within a heater housing and includes a plurality of fuel cells which convert chemical energy from a fuel into heat and electricity through a chemical reaction with an oxidizing agent. A combustor disposed within the heater housing receives an anode exhaust and a cathode exhaust from the fuel cell stack assembly and combusts a mixture of the anode exhaust and the cathode exhaust to produce a heated combustor exhaust. The combustor includes a combustor exhaust outlet for discharging the heated combustor exhaust into the heater housing. A baffle disposed around the fuel cell stack assembly and the combustor defines a heat transfer channel radially between the heater housing and the baffle. A flow director in fluid communication with the combustor exhaust outlet and the heat transfer channel communicates the heated combustor exhaust to the heat transfer channel.

Abstract: A heater includes a heater housing with a support plate secured to one end. A fuel cell stack assembly is disposed within the heater housing and includes a plurality of fuel cells which convert chemical energy from a fuel into heat and electricity through a chemical reaction with an oxidizing agent. The fuel cell stack assembly includes a fuel cell manifold for receiving the fuel and distributing the fuel to the plurality of fuel cells and for receiving the oxidizing agent and distributing the oxidizing agent to the plurality of fuel cells. A fuel supply conduit supplies the fuel to the fuel cell manifold and an oxidizing agent supply conduit supplies the oxidizing agent to the fuel cell manifold. The fuel cell stack assembly is supported on the support plate by one of the fuel supply conduit and the oxidizing agent supply conduit.

Abstract: A heater includes a heater housing extending along a heater axis; a fuel cell stack assembly disposed within the heater housing and having a plurality of fuel cells which convert chemical energy from a fuel into heat and electricity through a chemical reaction with an oxidizing agent; an electric resistive heating element disposed within the heater housing and electrically connected to the fuel cell stack assembly; and a first thermal switch located between the fuel cell stack assembly and the electric resistive heating element. The first thermal switch is closed to place the fuel cell stack assembly in electrical communication with the electric resistive heating element when the fuel cell stack assembly is electrochemically active and is open to prevent electrical communication between the fuel cell stack assembly and the electric resistive heating element when the fuel cell stack assembly is not electrochemically active.

Abstract: Disclosed is a dry-powder peptide medicament with a non-typical concentration of carbohydrate excipient, as well as said medicament for use in treatment or prevention of a disease or condition, as well as methods for manufacturing said medicament.

Abstract: In addition to liquid in a thermal volume-neutral stroke transmitter, first and/or second displacement body(ies) is/are positioned in the stroke transmitter, for displacing the liquid. These three materials in the closed system are designed so that the stroke transmitter remains pressure-free during temperature changes.

Abstract: A method for a logic circuit including a plurality of components and channels which are each assigned functional properties in a circuit model to simulate how the logic circuit functions, where the circuit model, in a section of the method, is expanded by mechanisms for security analysis, and where in a further section of the method, the following method steps are implemented via a simulation unit, i.e., check whether the security property of the respective component and/or the respective channel corresponds to the security requirement of the security-relevant data and generate a security risk report if it does not correspond thereto, apply a modeled attack to a component and/or to a channel, and determine a vulnerability of the security property of the respective component and/or of the respective channel to the applied attack, and if there is vulnerability of the security property, generate an attack report.

Abstract: A heater assembly includes a plurality of fuel cell stack assemblies which each have a plurality of fuel cells, a fuel inlet, and an air inlet; a fuel supply conduit which communicates fuel to the fuel inlets; and an air supply conduit which communicates air to the air inlets. An orifice is disposed between the fuel supply conduit and the fuel inlet or between the air supply conduit and the air inlet of each fuel cell stack assembly. The plurality of fuel cell stack assemblies are arranged in fuel cell stack assembly groups such that the orifices of each of the fuel cell stack assembly groups are configured to provide a magnitude of restriction that is unique to their respective the fuel cell stack assembly group, thereby providing uniformity of flow of the fuel or the air to the plurality of fuel cell stack assemblies.

Abstract: A cyclized compound of the amino acid sequence of formula I X1-GQRETPEGAEAKPWY-X2 wherein X1 comprises an amino acid (sequence) with 1 to 4, in particular 1 to 3 members, comprising natural or unnatural amino acids, in particular selected from the amino acid (sequence) C, KSP, K, ornithin, 4-amino butanoic acid, ?-alanine, and X2 comprises one amino acid, selected from natural amino acids, in particular selected from the group C, D, G and E, and wherein X1 comprises the N-terminal amino acid at ist first left position and X2 comprises the C-terminal amino acid at its last right position, optionally in the form of a salt for use in the treatment of inflammation, a pharmaceutical composition for treating inflammation comprising such compound and a method of treating inflammation comprising administering an effective amount of such compound to a mammal in need thereof.

Abstract: A turbo-machine having a plurality of component slots accessible from the outside, wherein a thermal transfer line is supplied to at least one section of a component slot such that, upon escape of leakage gas out of the section of the component slot, the leakage gas thermally interacts with the thermal transfer line, wherein the thermal transfer line has a plurality of temperature sensors at different locations on the thermal transfer line and the temperature sensors are designed to detect temperature values on the thermal transfer line at the different locations.

Abstract: A method is provided for operating a heater including a heater housing extending along a heater axis; a plurality of fuel cell stack assemblies disposed within the heater housing along the heater axis and having a plurality of fuel cells which convert chemical energy from a fuel cell fuel into heat and electricity through a chemical reaction with a fuel cell oxidizing agent; and a plurality of combustors disposed within the heater housing along the heater axis. The method includes supplying a combustor fuel to the plurality of combustors, combusting the combustor fuel to produce a heated combustor exhaust when the fuel cell stack assemblies are substantially electrochemically inactive, and using the heated combustor exhaust to elevate the temperature of the fuel cell stack assemblies to be electrochemically active.

Abstract: A heater includes a heater housing extending along a heater axis. A fuel cell stack assembly is disposed within the heater housing and includes a plurality of fuel cells which convert chemical energy from a fuel into heat and electricity through a chemical reaction with an oxidizing agent. A combustor disposed within the heater housing receives an anode exhaust and a cathode exhaust from the fuel cell stack assembly and combusts a mixture of the anode exhaust and the cathode exhaust to produce a heated combustor exhaust. The combustor includes a combustor exhaust outlet for discharging the heated combustor exhaust into the heater housing. The heater housing is heated by the fuel cell stack assembly and the heated combustor exhaust.

Abstract: A heater includes a heater housing with a fuel cell stack assembly disposed therein. The fuel cell stack assembly includes a plurality of fuel cells which convert chemical energy from a fuel into heat and electricity through a chemical reaction with an oxidizing agent. The fuel cell stack assembly includes a fuel cell manifold for receiving the fuel within a fuel inlet and the oxidizing agent within an oxidizing agent inlet and distributing the fuel and oxidizing agent to the fuel cells. A fuel supply conduit supplies the fuel to the fuel inlet and an oxidizing agent supply conduit supplies the oxidizing agent to the oxidizing agent inlet. A sonic orifice is disposed between the fuel supply conduit and the fuel inlet or between the oxidizing agent supply conduit and the oxidizing agent inlet, thereby limiting the velocity of the fuel or the oxidizing agent through the sonic orifice.