Abstract: An embodiment includes a method of real-time, endpoint-specific SLA compliance evaluation in a managed network. The method includes receiving SLA definition input that indicates an SLA definition of the managed network. Responsive to detection of a trigger event, the method includes initiating a scan of endpoints including retrieval of endpoint-level state data. The method includes identifying a portion of the retrieved state data relevant to the SLA definition. The method includes aggregating the portions of the retrieved state data. The method includes determining whether the managed network is SLA compliant at an endpoint-level of granularity based on the aggregated portions. Responsive to the managed network being noncompliant, the method includes identifying a subset of endpoints failing to meet the SLA definition and implementing a product modification process to address a metric of the SLA definition and change a product to bring the first endpoint into compliance.

Abstract: The present disclosure provides a method for enrichment of at least one target nucleic acid in a library of nucleic acids. A first oligonucleotide is hybridized to a target nucleic acid in library of nucleic acids having first and second adapters. The hybridized first oligonucleotide is extended with a first polymerase, thereby producing a first primer extension complex including the target nucleic acid and the extended first oligonucleotide. The first primer extension complex is captured, enriched relative to the library of nucleic acids, and a second oligonucleotide is hybridized to the target nucleic acid. The hybridized second oligonucleotide is extended with a second polymerase, thereby producing a second primer extension complex including the target nucleic acid and the extended second oligonucleotide, and further liberating the extended first oligonucleotide from the first primer extension complex.

Abstract: A service implemented at a first isolated virtual network of a provider network is added to a database of privately-accessible services. Configuration changes that enable network packets to flow between the first isolated virtual network and a second isolated virtual network without utilizing a network address accessible from the public Internet are implemented. Service requests originating at the second isolated virtual network are transmitted to the first isolated virtual network via private pathways of the provider network. Metrics corresponding to service requests directed from the second isolated network to the service are collected and provided to the respective owners of one or both isolated virtual networks.

Abstract: A solar panel assembly includes a substrate and a solar array coupled to the substrate. The solar array includes a plurality of photovoltaic cells. An optical layer is disposed over the solar array. The optical layer, the solar array, and the substrate together form a solar assembly. A frame surrounds the solar assembly and includes a plurality of frame members. Each frame member of the plurality of frame members includes an arcuate member that forms an aerodynamic outer edge of the frame member.

Abstract: Techniques for building automated workflow sequences associated with a document review platform are provided. A method includes accessing trigger event data from a trigger event database and action data from an action database; presenting a user interface to create a workflow; adding a function block to the workflow by: detecting a selection of an add function block option; presenting a function block including at least one of (i) a user-selectable option to select a trigger event from a list of trigger events populated based on the trigger event data or (ii) a user-selectable option to select an action from a list of actions populated based on the action data; and presenting the function block including at least one of a selected trigger event or a selected action; detecting that the workflow is ready for deployment; translating the workflow into a logic-based representation of the workflow; and deploying the logic-based representation.

Abstract: Devices and methods for mixing and preparing therapeutic pellets are described. In one aspect, the present disclosure may include a medical device for mixing and preparing pharmaceuticals. The medical device may include a body sized and shaped to be supported by a human hand. The body may be elastically flexible between a relaxed shape and a flexed shape. In the relaxed shape, the body may form a basin and may be shaped and sized to receive a vessel for mixing or forming the therapeutic pellets. In the flexed shape, the bowl may be configured for controlled pouring of the therapeutic pellets.

Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

Abstract: An illustrative method includes determining that a total amount of read traffic and write traffic processed by a storage system during a time period exceeds a threshold; determining a first compressibility metric associated with the write traffic; determining a second compressibility metric associated with the read traffic; determining, based on a comparison of the first compressibility metric with the second compressibility metric, that the write traffic is less compressible than the read traffic; determining, based on the total amount of read traffic and write traffic exceeding the threshold and on the write traffic being less compressible than the read traffic, that the storage system is possibly being targeted by a security threat; and modifying, in response to the determining that the storage system is possibly being targeted by the security threat, a data protection parameter set for one or more recovery datasets generated by the storage system.

Abstract: The invention is directed to an engineered yeast including an exogenous nucleic acid encoding a glucoamylase comprising SEQ ID NO:1 and SEQ ID NO:4, or a variant thereof. The engineered yeast are able to provide glucoamylase into a fermentation media and cause degradation of starch material generating glucose for fermentation to a desired bioproduct, such as ethanol. High titers of bioproduct (e.g., 70 g/kg of ethanol) can be achieved, along with low residual glucose levels. Further the yeast exhibit good growth and bioproduct product at temperatures of 32° C. or greater.

Abstract: One embodiment is directed to a user display device comprising a housing frame mountable on the head of the user, a lens mountable on the housing frame and a projection sub system coupled to the housing frame to determine a location of appearance of a display object in a field of view of the user based at least in part on at least one of a detection of a head movement of the user and a prediction of a head movement of the user, and to project the display object to the user based on the determined location of appearance of the display object.

Abstract: Systems and methods of a laser welding device are disclosed. The laser welding device includes a laser generator configured to generate welding-type lasing power. A lens focuses the welding-type lasing power at a focal point on a workpiece to generate a puddle during a welding-type operation. A wire feeder is configured to feed wire to the puddle generated by the laser generator. A laser scanner controls the lens to move the focal point of the welding-type lasing power in multiple dimensions over the workpiece during the welding-type operation. In some examples, the feed wire is used in an additive manufacturing process.

Abstract: Systems and methods for adaptively tuning a Proportional, Integral and Derivative (PID) controller in a zero order industrial process are provided. A method and system can involve receiving input data at one or more inputs of the PID controller and generating output data at one or more outputs of the PID controller in response to processing the input data. Error(s) associated with the controller are determined based on an analysis of a measured parameter with respect to a desired setpoint. The measured parameter may be indicated in the output data. Adaptive gain may be applied to the PID controller in response to the absolute value of the controller error both exceeding a deadband and increasing. Additionally, normal gain, which is lower than the adaptive gain, may be applied to the PID controller in response to the absolute value of the controller error either being below the deadband or decreasing.

Abstract: Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

Abstract: A rental self-service (“RSS”) computer system, including a processor and a memory, is provided. The processor is programmed to: (i) verify that a policyholder is eligible to receive a replacement rental; (ii) transmit a customized link to the eligible policyholder; (iii) receive an access request for access of a rental self-service portal, (iv) retrieve policyholder data using information extracted from the customized link; (v) pre-populate a portion of a searchable interface of the rental self-service portal using the retrieved policyholder data; (vi) cause rental vehicle data to be displayed to enable the policyholder to view available rental options and select a vehicle class; (vii) calculate a policyholder cost for renting a selected vehicle class; and (viii) cause to be displayed on the user device (a) the calculated policyholder cost and (b) an option to confirm the rental reservation.

Abstract: An analog tamper-detection apparatus (ATAMP) for onboard analysis of a target device includes a plurality of antennas, each antenna of the plurality of antennas disposed within the target device and being electrically isolated from components of the target device. The ATAMP device further includes radio frequency (RF) front-end (RFFE) transmitter circuitry coupled to the plurality of antennas, the RFFE transmitter circuitry configured to illuminate the target device with a plurality of electromagnetic signals emitted via the plurality of antennas, to generate a plurality of mixed RF signals. The ATAMP device further includes RFFE receiver circuitry configured to receive emissions from the target device based on the mixed RF signals, and processing circuitry configured to perform subsequent analysis and evaluation of the target device based on the received emissions. The processing circuitry further generates a notification of the subsequent analysis and evaluation.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server. The approaches include intercepting requests to the SaaS server from a user group and monitoring both a rate of API calls for the requests and a rate of API events generated by forwarding the API calls to the SaaS server, intercepting the SaaS server's responses, where some of the responses indicate a throughput penalty imposed by the server, identifying one or more power users from the user group based on the rate of generated notifications, and throttling the rate of the API calls for the requests submitted by the identified power users of the user group to the SaaS server in accordance with an API call throttle limit, thus reducing triggering of the throughput penalty.

Abstract: An ink composition includes a polymeric binder having an addition copolymer and a ketone aldehyde resin. The addition copolymer is chosen from acrylic resins, vinyl resins including copolymers of vinyl chloride and vinyl acetate, and mixtures and combinations thereof. The ink composition further includes a liquid carrier with at least one organic solvent.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server is disclosed. The approaches include actions of intercepting requests to the SaaS server from a user group and monitoring both a rate of API calls for the requests and a rate of API events generated by forwarding the API calls to the SaaS server, intercepting the SaaS server's responses, where some of the responses indicate a throughput penalty imposed by the server, inferring load conditions of the SaaS server by analyzing the varying rate of API events against the responses with imposition of throughput penalty and setting an API call throttle limit dynamically adaptive to the inferred load conditions, then throttling the rate of the API calls for the group's requests according to the throttle limit.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server is disclosed. The approaches include actions of intercepting requests to the SaaS server from a user group and monitoring both a rate of API calls for the requests and a rate of API events generated by forwarding the API calls to the SaaS server, intercepting the SaaS server's responses, where some of the responses indicate a throughput penalty imposed by the server, inferring load conditions of the SaaS server by analyzing the varying rate of API events against the responses with imposition of throughput penalty and setting an API call throttle limit dynamically adaptive to the inferred load conditions, then throttling the rate of the API calls for the group's requests according to the throttle limit.

Abstract: A system for adjusting the compliance of a wheel is provided. In one embodiment, wheel segments are adjusted, causing the stiffness of the wheel to change. Such adjustments can be made while the wheel is rotating, allowing the wheel compliance to be changed while a vehicle is in motion.