Abstract: Systems and methods dynamically adjust an available range for editing an attribute in an image. An image editing system computes a metric for an attribute in an input image as a function of a latent space representation of the input image and a filtering vector for editing the input image. The image editing system compares the metric to a threshold. If the metric exceeds the threshold, then the image editing system selects a first range for editing the attribute in the input image. If the metric does not exceed the threshold, a second range is selected. The image editing system causes display of a user interface for editing the input image comprising an interface element for editing the attribute within the selected range.

Abstract: Provided herein are compounds of formula (I): and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.

Abstract: A cabling system for extending electronic signals between devices is disclosed. The cabling system includes an extension cable connecting a female source connector and a destination connecter. The female source connector is housed within a headshell that is configured to mount to a wallplate, a table insert, or a rack panel within meeting and conference locations.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: An improved system architecture uses a pipeline including a Generative Adversarial Network (GAN) including a generator neural network and a discriminator neural network to generate an image. An input image in a first domain and information about a target domain are obtained. The domains correspond to image styles. An initial latent space representation of the input image is produced by encoding the input image. An initial output image is generated by processing the initial latent space representation with the generator neural network. Using the discriminator neural network, a score is computed indicating whether the initial output image is in the target domain. A loss is computed based on the computed score. The loss is minimized to compute an updated latent space representation. The updated latent space representation is processed with the generator neural network to generate an output image in the target domain.

Abstract: Systems and methods generate a filtering function for editing an image with reduced attribute correlation. An image editing system groups training data into bins according to a distribution of a target attribute. For each bin, the system samples a subset of the training data based on a pre-determined target distribution of a set of additional attributes in the training data. The system identifies a direction in the sampled training data corresponding to the distribution of the target attribute to generate a filtering vector for modifying the target attribute in an input image, obtains a latent space representation of an input image, applies the filtering vector to the latent space representation of the input image to generate a filtered latent space representation of the input image, and provides the filtered latent space representation as input to a neural network to generate an output image with a modification to the target attribute.

Abstract: The present disclosure describes systems, methods, and non-transitory computer readable media for detecting user interactions to edit a digital image from a client device and modify the digital image for the client device by using a web-based intermediary that modifies a latent vector of the digital image and an image modification neural network to generate a modified digital image from the modified latent vector. In response to user interaction to modify a digital image, for instance, the disclosed systems modify a latent vector extracted from the digital image to reflect the requested modification. The disclosed systems further use a latent vector stream renderer (as an intermediary device) to generate an image delta that indicates a difference between the digital image and the modified digital image. The disclosed systems then provide the image delta as part of a digital stream to a client device to quickly render the modified digital image.

Abstract: The present invention relates, in part, to methods, systems and processes for large-scale purification of mRNA using a filtering centrifuge operating at lower gravitational forces. The invention also relates to compositions of purified mRNA and uses thereof.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer readable media for generating painted digital images utilizing an intelligent painting process that includes progressive layering, sequential brushstroke guidance, and/or brushstroke regularization. For example, the disclosed systems utilize an image painting model to perform progressive layering to generate and apply digital brushstrokes in a progressive fashion for different layers associated with a background canvas and foreground objects. In addition, the disclosed systems utilize sequential brushstroke guidance to generate painted foreground objects by sequentially shifting through attention windows for regions of interest in a target digital image. Furthermore, the disclosed systems utilize brushstroke regularization to generate and apply an efficient brushstroke sequence to generate a painted digital image.

Abstract: An item recommendation system receives a set of recommendable items and a request to select, from the set of recommendable items, a contrast group. The item recommendation system selects a contrast group from the set of recommendable items by applying a image modification model to the set of recommendable items. The image modification model includes an item selection model configured to determine an unbiased conversion rate for each item of the set of recommendable items and select a recommended item from the set of recommendable items having a greatest unbiased conversion rate. The image modification model includes a contrast group selection model configured to select, for the recommended item, a contrast group comprising the recommended item and one or more contrast items. The item recommendation system transmits the contrast group responsive to the request.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for latent-based editing of digital images using a generative neural network. In particular, in one or more embodiments, the disclosed systems perform latent-based editing of a digital image by mapping a feature tensor and a set of style vectors for the digital image into a joint feature style space. In one or more implementations, the disclosed systems apply a joint feature style perturbation and/or modification vectors within the joint feature style space to determine modified style vectors and a modified feature tensor. Moreover, in one or more embodiments the disclosed systems generate a modified digital image utilizing a generative neural network from the modified style vectors and the modified feature tensor.

Abstract: A supercontinuum source including a pump source and a supercontinuum generator configured for receiving electromagnetic radiation derived from the pump source and for generating supercontinuum radiation, the supercontinuum generator including a nonlinear microstructured optical fibre having a core region comprising silica. The core region includes a dopant selected to reduce light-induced non-bridging oxygen hole centre loss in the nonlinear microstructured optical fibre.

Abstract: Described is a weighing luggage rack having a rack portion with a top section and a bottom section, and a platform portion connected with the top section of the rack portion. In use, the platform portion is stacked on top of the rack portion. The weighing luggage rack further includes a weighing mechanism, and an electronic display configured to display a weight of an object placed thereon. Further embodiments include a weighing luggage rack with only a rack portion and a weighing luggage rack with only a platform portion.

Abstract: A securing device (10) for securing a first object (320) relative to a second object (322) includes a device body (12) that is formed from a material so that the device body (12) exhibits elongation of greater than four hundred percent. The material that forms the device body (12) has (i) an average dielectric strength of greater than 200 volts per mil and less than 700 volts per mil at 75 degrees Fahrenheit, and (ii) an average breakdown voltage of greater than 30,000 volts and less than 60,000 volts at 75 degrees Fahrenheit. The device body (12) is also formed from the material so that the device body (12) exhibits a tensile strength of between four thousand five hundred kPa and nine thousand three hundred kPa. The material that forms the device body (12) can include thermoplastic elastomers, and can further include styrene.

Abstract: Disclosed herein are generative manifold networks (GMNs) which enable accurate prediction and modeling of complex interconnected systems.

Abstract: The present disclosure describes systems, methods, and non-transitory computer readable media for detecting user interactions to edit a digital image from a client device and modify the digital image for the client device by using a web-based intermediary that modifies a latent vector of the digital image and an image modification neural network to generate a modified digital image from the modified latent vector. In response to user interaction to modify a digital image, for instance, the disclosed systems modify a latent vector extracted from the digital image to reflect the requested modification. The disclosed systems further use a latent vector stream renderer (as an intermediary device) to generate an image delta that indicates a difference between the digital image and the modified digital image. The disclosed systems then provide the image delta as part of a digital stream to a client device to quickly render the modified digital image.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Described is a folding portable luggage scale. The folding portable luggage scale includes multiple folding arms connected via hinges, multiple load sensors, and an electronics housing including electronic components and a digital display. Electrical wires connect each load sensor with the electronics housing. The folding portable luggage scale is compact and lightweight for storage in luggage during travel.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.