Abstract: A method for managing thermal energy of a vehicle having a battery and an electric propulsion system is provided. The system monitors a current battery temperature, after the vehicle is connected to an outside power source at a plug time, and determines an outside air temperature. The system predicts a cabin heating temperature for a subsequent drive cycle. The subsequent drive cycle occurs when the vehicle is no longer connected to the outside power source. If the predicted cabin heating temperature is greater than the outside air temperature, the system heats the battery to a thermal storage temperature that is greater than a target operating temperature of the battery. Therefore, thermal energy is stored within the battery, and may be transferred to heat the cabin.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A securing device (10) for securing a first object (320) relative to a second object (322) includes a device body (12) having a cross-sectional area, and which is formed from a material so that the device body (12) exhibits elongation of between six hundred percent and eight hundred percent. A ratio of the elongation (in percent) to the cross-sectional area (in square millimeters) is between approximately 5:1 and 10:1. The device body (12) is also formed from the material so that the device body (12) exhibits a tensile strength of between four thousand five hundred kPa and nine thousand three hundred kPa. A ratio of the tensile strength (in kPa) to the cross-sectional area (in square millimeters) is between approximately 50:1 and 85:1. The material that forms the device body (12) has an average kinetic coefficient of friction of between approximately 1.35 and 1.60 relative to itself. The material that forms the device body (12) can include thermoplastic elastomers, and can further include styrene.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: An exercise bay including: an enclosure defining an exercise area; at least one camera directed toward the exercise area for capturing video of a user exercising in the exercise area; and at least one display within the enclosure for displaying content to the user.

Abstract: A system and method for managing thermal energy of a vehicle having a battery and an electric propulsion system are provided. The system monitors a current battery temperature, calculates an actual average battery temperature, and compares the calculated actual average battery temperature to a target lifetime battery temperature. If the actual average battery temperature is greater than the target lifetime battery temperature, and the current battery temperature is greater than the target lifetime battery temperature, the system cools the battery to below the current battery temperature. However, if the actual average battery temperature is less than the target lifetime battery temperature, and the current battery temperature is greater than the target lifetime battery temperature, the system delays cooling the battery. Therefore, the system may avoid expending energy to cool the battery in certain conditions.

Abstract: A method for managing thermal energy of a vehicle having a battery and an electric propulsion system is provided. The system monitors a current battery temperature, after the vehicle is connected to an outside power source at a plug time, and determines an outside air temperature. The system predicts a cabin heating temperature for a subsequent drive cycle. The subsequent drive cycle occurs when the vehicle is no longer connected to the outside power source. If the predicted cabin heating temperature is greater than the outside air temperature, the system heats the battery to a thermal storage temperature that is greater than a target operating temperature of the battery. Therefore, thermal energy is stored within the battery, and may be transferred to heat the cabin.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A supercontinuum source, comprises a pump source and a supercontinuum generator configured for receiving electromagnetic radiation derived from the pump source and for generating supercontinuum radiation, the supercontinuum generator comprising a nonlinear microstructured optical fibre having a core region comprising silica. The core region includes a dopant selected to reduce light-induced non-bridging oxygen hole centre loss in the nonlinear microstructured optical fibre.

Abstract: A securing device (10) for securing a first object (320) relative to a second object (322) includes a device body (12) having a cross-sectional area, and which is formed from a material so that the device body (12) exhibits elongation of between six hundred percent and eight hundred percent. A ratio of the elongation (in percent) to the cross-sectional area (in square millimeters) is between approximately 5:1 and 10:1. The device body (12) is also formed from the material so that the device body (12) exhibits a tensile strength of between four thousand five hundred kPa and nine thousand three hundred kPa. A ratio of the tensile strength (in kPa) to the cross-sectional area (in square millimeters) is between approximately 50:1 and 85:1. The material that forms the device body (12) has an average kinetic coefficient of friction of between approximately 1.35 and 1.60 relative to itself. The material that forms the device body (12) can include thermoplastic elastomers, and can further include styrene.

Abstract: A system and method are presented for predicting workload demand in a customer journey application. Using historical information from journey analytics, journey moments can be aggregated through various stages. Probability-distribution-vectors can be approximated for various paths connected the stages. Stability of such probability distribution can be determined through statistical methods. Predictions for future volumes progressing through the stages can be determined through recursive algorithms after applying a time-series forecasting algorithm at the originating stage(s). Once future volumes have been forecasted at every stage, future workload can be estimated to better capacity planning and scheduling of resources to handle such demand to achieve performance metrics along the cost function.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: Baking (e.g., pancake) mixes comprising at least one type of whole grain flour, at least one natural sweetener, at least one solid fat and a leavening system are provided herein. Packaged food products comprising single-serving containers containing said baking (e.g., pancake) mixes, as well as methods of preparing pancakes, are also provided. The baked goods (e.g., pancakes) described herein are preferably 100% whole grain and free from preservatives and/or artificial colorings.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.