Abstract: The present disclosure relates to compositions for reprogramming cells into conventional dendritic cells (cDC), particularly into cDC type 2 (hereinafter referred to as“cDC2” or“CD11b-positive dendritic cells”), methods and uses thereof. The present disclosure relates to the development of methods for making conventional dendritic cells With antigen presenting capacity from differentiated, multipotent or pluripotent stem cells by introducing and expressing isolated/synthetic transcription factors. More particularly, the disclosure provides methods for obtaining conventional dendritic cells (cDC), particularly cDC type 2 or CD11b-positive dendritic cells, by direct cell reprogramming With the surprisingly use of combinations of specific transcription factors.

Abstract: A structural arrangement for a motorcycle helmet the protective shell of which has a recessed cavity in the upper portion forming protrusions, each protrusion having a space for the rack, and an opening; a front cavity receives a rear fairing and has a second lowered cavit with an opening between the protective hull and the internal hull, on the edges of the visors is fastened a rack with teeth actuated by a small engine with gear strategically arranged in each of the outlets of the protrusions, in the protective hull and on one end of the rack, with actuation by buttons on the helmet or devices with electronic controls by means of radio signals, installed both on the helmet and on the motorcycle or even by remote control, and power is supplied by a battery.

Abstract: The present disclosure relates to a hydrogel fibre comprising an ionic hydrogel and a second component in a plurality of compartments, wherein the second component is selected from a second hydrogel, a hydrophilic solution, or a mixture thereof. It is also disclosed the method to obtain the aforesaid hydrogel fibres. This disclosure also relates to a composition comprising the hydrogel fibres and a suitable carrier, and an article/kit, a bundle, a mesh or a membrane comprising the hydrogel fibre. A composition comprising an ionic hydrogel and a second component for use in medicine administered in a hydrogel fibre comprising a plurality of compartments is also disclosed.

Abstract: The invention relates to an electronic padlock cover with a knob, wherein the padlock includes a rotor assembly formed by an electronic cylinder joined in continuity to an electronic knob, a body wherein the cylinder and a padlock ring are housed, wherein the cover includes a protective casing of the body intended to surround and protect the body of the padlock on one end, a support with a ring-shaped configuration including two grooves and an extension, centered on each groove, which includes a pair of first holes for the introduction of corresponding fastening screws for fastening to the body of the padlock and a protective casing of the knob including two flanges located in correspondence with the grooves, including an inner cylindrical opening for the housing of the knob.

Abstract: The present invention relates to a symmetrical and reversible-clutch mortise lock comprising a central follower, a pair of symmetrical lateral followers, each one located on one side of the central follower to be activated by square bars of handles, a spacer which makes the movement of the two lateral followers independent and a motor, which connects to an actuation lever and which is activated when an access code is validated. The lock further comprises a clutch housed and guided in an accumulator arm able to move linearly to be housed in both lateral followers such that the corresponding lateral follower, when activated by the motion of the door handle, pushes the clutch until it makes contact with the central follower and activates the latch of the lock.

Abstract: The invention relates to an electronic padlock cover with a knob, wherein the padlock includes a rotor assembly formed by an electronic cylinder joined in continuity to an electronic knob, a body wherein the cylinder and a padlock ring are housed, wherein the cover includes a protective casing of the body intended to surround and protect the body of the padlock on one end, a support with a ring-shaped configuration including two grooves and an extension, centered on each groove, which includes a pair of first holes for the introduction of corresponding fastening screws for fastening to the body of the padlock and a protective casing of the knob including two flanges located in correspondence with the grooves, including an inner cylindrical opening for the housing of the knob.

Abstract: The present invention relates to a symmetrical and reversible-clutch mortise lock comprising a central follower, a pair of symmetrical lateral followers, each one located on one side of the central follower to be activated by square bars of handles, a spacer which makes the movement of the two lateral followers independent and a motor, which connects to an actuation lever and which is activated when an access code is validated. The lock further comprises a clutch housed and guided in an accumulator arm able to move linearly to be housed in both lateral followers such that the corresponding lateral follower, when activated by the motion of the door handle, pushes the clutch until it makes contact with the central follower and activates the latch of the lock.

Abstract: Mostly, motion signals are inaccurate, especially if the mobile device is not a proprietary device, and one has to reckon that the bearer wears the mobile device somewhere else than where it is supposed to be worn in order to coincide with the laboratory conditions. However, the information conveyed by the motion signals is sufficient in order to discriminate and detect between different typical wearing/carrying conditions, and accordingly position tracking based on such motion signals may be rendered far more efficiently by, first of all, using the motion signals gained from the one or more motion sensors so as to attribute them to one of a plurality of analysis parameter sets so as to obtain a selected analysis parameter set and, second, analyzing the motion signals using the selected analysis parameter set so as to obtain a signal indicating a locomotion of the bearer.

Abstract: Mostly, motion signals are inaccurate, especially if the mobile device is not a proprietary device, and one has to reckon that the bearer wears the mobile device somewhere else than where it is supposed to be worn in order to coincide with the laboratory conditions. However, the information conveyed by the motion signals is sufficient in order to discriminate and detect between different typical wearing/carrying conditions, and accordingly position tracking based on such motion signals may be rendered far more efficiently by, first of all, using the motion signals gained from the one or more motion sensors so as to attribute them to one of a plurality of analysis parameter sets so as to obtain a selected analysis parameter set and, second, analyzing the motion signals using the selected analysis parameter set so as to obtain a signal indicating a locomotion of the bearer.

Abstract: Clutch actuating mechanism for electronic cylinders in locks and method for operating the same. The clutch actuating mechanism for an electronic cylinder in locks relates, in particular, to a clutch actuating mechanism which is responsible for storing the energy supplied by the motor and returning said energy to the clutch at the moment it passes from a clutched position to a declutched position, all of this being carried out with reduced energy consumption. It also relates to the method for operating said mechanism.

Abstract: Mostly, motion signals are inaccurate, especially if the mobile device is not a proprietary device, and one has to reckon that the bearer wears the mobile device somewhere else than where it is supposed to be worn in order to coincide with the laboratory conditions. However, the information conveyed by the motion signals is sufficient in order to discriminate and detect between different typical wearing/carrying conditions, and accordingly position tracking based on such motion signals may be rendered far more efficiently by, first of all, using the motion signals gained from the one or more motion sensors so as to attribute them to one of a plurality of analysis parameter sets so as to obtain a selected analysis parameter set and, second, analyzing the motion signals using the selected analysis parameter set so as to obtain a signal indicating a locomotion of the bearer.

Abstract: Clutch actuating mechanism for electronic cylinders in locks and method for operating the same. The clutch actuating mechanism for an electronic cylinder in locks relates, in particular, to a clutch actuating mechanism which is responsible for storing the energy supplied by the motor and returning said energy to the clutch at the moment it passes from a clutched position to a declutched position, all of this being carried out with reduced energy consumption. It also relates to the method for operating said mechanism.