Abstract: The construction of a mutant in the phoP gene by means of homologous recombination from a clinically isolated Mycobacterium tuberculosis reduces the virulence thereof in mouse bone marrow macrophage. Moreover, the phoP mutant reduces the virulence thereof in the experimental mouse model. Said phoP mutant can persist without being eliminated both in the macrophage and in the mouse. Mice inoculated with the phoP mutant are protected against M. tuberculosis infection. The use of mutants of mycobacteria in which the phoP gene or the genes regulated by phoP have been inactivated are candidates for vaccines against human and animal tuberculosis as well as possible recombinant vaccines against other pathogens.

Abstract: This invention relates to a process for the manufacturing of a protein in mammalian cells cultured in a serum-free medium.

Abstract: A control valve (10) for a fluid circulation circuit comprises a body (12) which is equipped with a fluid inlet (18) and at least two fluid outlets (20, 22 and 24) and which delimits a cylindrical housing for an adjusting member (26) able to rotate about an axis of rotation (XX) and to adopt various angular positions in order to control the distribution of fluid through the outlets. The body (12) comprises an end wall (14) into which the fluid inlet (18) opens and a cylindrical side wall (16) into which the fluid outlets open at axial heights and at angular positions that are chosen with respect to the axis of rotation (XX). The rotary member (26) comprises a truncated end (38) facing toward the end wall (14), this making it possible to have control over the fluid outlets using a law defined as a function of the angular position of the rotary member in the valve body.

Abstract: Catalyst component for the polymerization of alpha-olefins in solution, in suspension, in gas phase at low and high pressure and temperature or in mass at high pressures and high or low temperatures, characterized in that is defined by general formulas I or II wherein: R, equal to or different from each other, is hydrogen or a radical which contains from 1 to 20 carbon atoms; this group optionally contains heteroatoms of groups 14 to 16 of the periodic table of the elements and boron; at least one group R contains a group OSiR?3, Q is selected from a group comprising: boron or an element from groups 14 or 16 of the periodic table; m value can change from 1 to 4 and it preferably is 1 or 2; L, equal to or different from each other, is a cyclic organic group united to M through a ? bond, or it is an atom from groups 15 or 16 of the periodic table; L1 and L2, equal to or different from each other, have the same meaning of L; M is a metal from groups 3, 4, 10 of the periodic table, lanthanide or actinide.

Abstract: The cooling module consists of a charge air cooler and of a recirculated exhaust gas cooler. The charge air cooler comprises a heat exchange bundle (2), an inlet header box for the air that is to be cooled and an outlet header box for the cooled air. The recirculated exhaust gas cooler comprises a heat exchange bundle (4) for cooling the recirculated exhaust gases, an inlet header box for the recirculated exhaust gases and an outlet header box for these gases. A wrapper consisting of two half-casings (7 and 8) accommodates the exchange bundles (2 and 4). The charge air cooler heat exchange bundle (2) and the recirculated exhaust gas cooler heat exchange bundle (4) are assembled in a single brazing operation. They are also assembled with one another during this same brazing operation, possibly at the same time as the two half-casings (7 and 8).

Abstract: Heterogeneous catalytic compositions obtained by reacting a porous inorganic support with an alumoxane and subsequently supporting at least one metallocene compound thereon. A process for polymerization of ?-olefins in a slurry or in a gas phase, the process catalyzed by such heterogeneous catalytic compositions.

Abstract: A manifold for, e.g. a motor vehicle heat exchanger, has a first part formed from a shaped metal sheet and bottom and two lateral walls folded face-to-face, at least one of which is provided with an aperture for fixing a pipe there. A second part is shaped metal sheet and able to be fitted onto the lateral walls of the first part to form a cover opposite the bottom of this first part. Either the first part or the second part has a manifold plate. The first part, the second part and the pipe are assembled by brazing.

Abstract: The invention relates to a control valve for a fluid circulation system, consisting of a body (2) comprising a cylindrical lateral wall (4) which defines a cylindrical housing. The invention also comprises tubes (50, 52, 60, 62, 58) through which the fluid enters and leaves the aforementioned body (2). A rotary adjustment element (80) is mounted to rotate around an axis (XX) in the body (2) and can occupy different positions in order to control the circulation of the fluid between the tubes. All of said tubes pass through the cylindrical lateral wall (4) of the body (2).

Abstract: The heat exchanger support system (34, 36, 40) consists of a frame (2) comprising horizontal faces (4, 6) and vertical faces (8, 10) furnished with fixing means (42, 50, 72, 74, 80) for fixing heat exchange components such as a condenser (34), an engine cooling radiator (36), a motor-fan unit (38) and a supercharge air radiator (40). Each component is fixed directly to the frame (2) independently of the other components. The frame also comprises attachment elements (28, 30) allowing it to be mounted on a motor vehicle chassis via flexible vibration-damping means.

Abstract: A control valve (10) for a fluid circulation circuit comprises a body (12) which is equipped with a fluid inlet (18) and at least two fluid outlets (20, 22 and 24) and which delimits a cylindrical housing for an adjusting member (26) able to rotate about an axis of rotation (XX) and to adopt various angular positions in order to control the distribution of fluid through the outlets. The body (12) comprises an end wall (14) into which the fluid inlet (18) opens and a cylindrical side wall (16) into which the fluid outlets open at axial heights and at angular positions that are chosen with respect to the axis of rotation (XX). The rotary member (26) comprises a truncated end (38) facing toward the end wall (14), this making it possible to have control over the fluid outlets using a law defined as a function of the angular position of the rotary member in the valve body.

Abstract: The invention concerns a condenser consisting of stacked plates (2) provided each with a raised peripheral edge (3) in sealed assembly to define flow channels between the plates for a refrigerating fluid (F1) and a cooling fluid (F2). he plates comprise communicating passageways (124) for the passage of the refrigerating fluid and the cooling fluid from one flow channel to the other. Annular ducts (122) are provided opposite the communicating passageways to prevent the fluids from being mixed. A bottle (100) is interposed between a cooling section (94) and sub-cooling section (96). The invention is applicable to motor vehicles.

Abstract: A heat-exchange module has a main exchanger and at least one secondary exchanger, each having a body with fluid-circulation tubes, and cooling fins, the secondary exchanger being fixed onto the main exchanger. The module includes a set of fins common to the main exchanger and to at least one secondary exchanger, these fins being mounted on the tubes of the main exchanger and projecting from this exchanger, the projecting parts of the fins including cut-outs for accommodating the tubes of the secondary exchanger. Fastenings secure the secondary exchanger in the position in which its tubes are engaged in the cut-outs.

Abstract: A manifold for, e.g. a motor vehicle heat exchanger, has a first part formed from a shaped metal sheet and bottom and two lateral walls folded face-to-face, at least one of which is provided with an aperture for fixing a pipe there. A second part is shaped metal sheet and able to be fitted onto the lateral walls of the first part to form a cover opposite the bottom of this first part. Either the first part or the second part has a manifold plate. The first part, the second part and the pipe are assembled by brazing.

Abstract: A control valve (10) for a fluid circulation circuit comprises a body (12) which is equipped with a fluid inlet (18) and at least two fluid outlets (20, 22 and 24) and which delimits a cylindrical housing for an adjusting member (26) able to rotate about an axis of rotation (XX) and to adopt various angular positions in order to control the distribution of fluid through the outlets. The body (12) comprises an end wall (14) into which the fluid inlet (18) opens and a cylindrical side wall (16) into which the fluid outlets open at axial heights and at angular positions that are chosen with respect to the axis of rotation (XX). The rotary member (26) comprises a truncated end (38) facing toward the end wall (14), this making it possible to have control over the fluid outlets using a law defined as a function of the angular position of the rotary member in the valve body.

Abstract: A skateboard includes a step board and two wheel assemblies spacedly mounted underneath the step board, wherein each of the wheel assemblies includes two wheels and a truck unit. The truck unit includes a truck having two side ends rotatably mount the two wheels respectively, a washer pad mounted between the step board and the truck, and a safety alert system which includes a power source supported underneath the step board and at least an illuminator electrically connected to the power source, wherein the illuminator is positioned at an exterior of the truck to provide a light effect for enhancing a visibility of the skateboard so as to prevent unwanted accidents and improve safety.

Abstract: An aluminum based header plate, for a tubular heat exchanger for a motor vehicle, has an external coating on its outer face. An end portion of each heat exchanger tube is received in a corresponding through hole in the header plate. The tube end portions have a predetermined cross section and an external coating, and secured to the header plate by brazing. Each through hole is made by a slitting operation followed by configuration of the through hole within a selected zone of the header plate, this zone being press-formed so as to form in the outer face of the header plate a collar portion in that zone. The internal transverse cross section of each collar portion is substantially identical to the predetermined cross section of the corresponding tube end portion. After the tube has been introduced into the through hole, which extends through the collar portion, there is surface contact between the respective external coatings of the collar portion and of the tube end portion.

Abstract: Catalyst component for the polymerization of alpha-olefins of general formula (I) wherein: M is a transition metal of groups 3, 4-10 of the periodic table of the elements, Each X group can be equal or different and it is hydride, halogen, alkyl, cycloalkyl, aryl, alkenyl, arylalkyl, arylalkenyl or alkylaryl with 1 to 20 carbon atoms, linear or branched. L is a neutral Lewis base A is a ring with delocalized &pgr; electrons, that directly coordinates to the transition metal M. Each E group can be equal to or different from each other and it is BRIII, CRIV2, SiRIII2, GeRIII2; at least one E is SiRIII2. RII is hydrogen, alkyl, cycloalkyl, aryl, alkenyl, arylalkyl, arylalkenyl or alkylaryl from 1 to 20 carbon atoms, linear or branched, whose hydrogens can be substituted by SiR3, GeR3, OR, NR2, OSiR3 or any combination of thereof. It can moreover form a condensed ring through another bond with E.

Abstract: Catalyst component for the polymerization of alpha-olefins in solution, in suspension, in gas phase at low and high pressure and temperature or in mass at high pressures and high or low temperatures, characterised in that is defined by general formulas I or II 1

Abstract: The invention relates to heterogeneous catalytic systems obtainable by reacting a porous inorganic support with an alumoxane and subsequently supporting at least one metallocene compound thereon, characterized in that the metallocene compound is defined by the following general formulas: 1

Abstract: A heat exchanger for heat extraction of a refrigerating fluid such as CO2, comprising at least one collecting box defined by a solid body (41) with a thick wall capable of resisting the high pressure of said fluid, and communicating with a row of flat tubes (44). In order to limit bulkiness in the width of the heat exchanger, only one part of the length of the cross section of the tubes is located opposite the inner volume of said body, whereby tightness of the fluidic communication between the tubes and the inner volume is obtained by means of a cradle (50) in the form of a shaped strip receiving the body and brazed thereto on the periphery of the tubes. The heat exchanger can be used to air condition passenger compartments in vehicles.