Patents by Inventor Chaitan Khosla

Chaitan Khosla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DRUG THERAPY FOR CELIAC SPRUE
    Publication number: 20090312260
    Abstract: Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: August 4, 2009
    Publication date: December 17, 2009
    Inventors: CHAITAN KHOSLA, FELIX HAUSCH, ISABELLE PARROT, LU SHAN
  • Transglutaminase inhibitors and methods of use thereof
    Publication number: 20090312272
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: August 4, 2009
    Publication date: December 17, 2009
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis
    Patent number: 7628985
    Abstract: Pharmaceutical formulations of glutenase enzymes are provided. The enzymes find particular use in the treatment of a Celiac or dermatitis herpetiformis patient.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: December 8, 2009
    Assignees: The Board of Regents of the Leland Stanford Junior University, Alvine Pharmaceuticals, Inc.
    Inventors: Lu Shan, Michael Thomas Bethune, Chaitan Khosla, Jonathan David Gass
  • ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE
    Publication number: 20090280555
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: October 29, 2007
    Publication date: November 12, 2009
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Drug therapy for Celiac Sprue
    Patent number: 7605150
    Abstract: Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: October 20, 2009
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Felix Hausch
  • Transglutaminase inhibitors and methods of use thereof
    Patent number: 7579313
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: August 25, 2009
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Washington University
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Polynucleotides encoding the fkbB gene of the FK-520 polyketide synthase gene cluster
    Publication number: 20090186378
    Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
    Type: Application
    Filed: July 6, 2004
    Publication date: July 23, 2009
    Inventors: Christopher Reeves, Daniel Chu, Chaitan Khosla, Daniel Santi, Kai Wu
  • Recombinant Methods and Materials for Producing Epothilone and Epothilone Derivatives
    Publication number: 20090170172
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 2, 2009
    Applicant: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • PEPTIDES FOR DIAGNOSTIC AND THERAPEUTIC METHODS FOR CELIAC SPRUE
    Publication number: 20090156490
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
    Type: Application
    Filed: September 25, 2008
    Publication date: June 18, 2009
    Inventors: Chaitan Khosla, Jiang Xia, Matthew John Siegel
  • Glutenase enzyme assays
    Patent number: 7534426
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: May 19, 2009
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Justin L. Piper, Gary M. Gray, Chaitan Khosla
  • Production of Polyketides
    Publication number: 20090111151
    Abstract: Recombinant host cells of the suborder Cystobacterineae containing recombinant expression vectors that encode heterologous PKS genes can produce polyketides synthesized by the PKS enzymes encoded on those vectors at high levels.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 30, 2009
    Applicant: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla
  • TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20090042806
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: August 28, 2006
    Publication date: February 12, 2009
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Peptides for diagnostic and therapeutic methods for celiac sprue
    Patent number: 7462688
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: December 9, 2008
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Jiang Xia, Matthew John Siegel
  • Peptides for Diagnostic and Therapeutic Methods for Celiac Sprue
    Publication number: 20080299108
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
    Type: Application
    Filed: August 3, 2006
    Publication date: December 4, 2008
    Inventors: Chaitan Khosla, Jiang Xia, Matthew John Siegel
  • Drug Therapy for Celiac Sprue
    Publication number: 20080233102
    Abstract: Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: November 12, 2004
    Publication date: September 25, 2008
    Inventors: Chaitan Khosla, Kihang Choi
  • ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE
    Publication number: 20080213245
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: October 29, 2007
    Publication date: September 4, 2008
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE
    Publication number: 20080213427
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: October 29, 2007
    Publication date: September 4, 2008
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • METHODS FOR DIAGNOSING CELIAC SPRUE AND REAGENTS USEFUL THEREIN
    Publication number: 20080213822
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: October 29, 2007
    Publication date: September 4, 2008
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
    Publication number: 20080200659
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Application
    Filed: October 2, 2006
    Publication date: August 21, 2008
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Camilla M. Kao
  • Therapeutic Enzyme Formulations And Uses Thereof
    Publication number: 20080193436
    Abstract: Pharmaceutical formulations of glutenase enzymes are provided. The enzymes find particular use in the treatment of a Celiac or dermatitis herpetiformis patient.
    Type: Application
    Filed: February 23, 2005
    Publication date: August 14, 2008
    Inventors: Lu Shan, Michael Bethune, Chaitan Khosla, Jonathan David Gass