Patents by Inventor Chaitan Khosla

Chaitan Khosla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 7402421
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: July 22, 2008
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE
    Publication number: 20080145356
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: October 29, 2007
    Publication date: June 19, 2008
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan A. Khosla
  • Fermentation and purification of migrastatin and analog
    Patent number: 7375230
    Abstract: Migrastatin and a migrastatin analog can be produced by fermentation of Streptomyces platensis NRRL 18993 and used in pharmaceutical formulations to treat cancer and/or inhibit metastasis of cancer cells.
    Type: Grant
    Filed: May 3, 2004
    Date of Patent: May 20, 2008
    Assignee: Kosan Biosciences, Inc.
    Inventors: Chaitan Khosla, Peter J. Licari, John R. Carney
  • ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE
    Publication number: 20080095710
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: July 10, 2007
    Publication date: April 24, 2008
    Inventors: Lu Shan, Michael Bethune, Chaitan Khosla, Jonathan Gass, Gail Pyle, Gary Gray, Indu Isaacs, Gregg Strohmeier
  • DRUG THERAPY FOR CELIAC SPRUE
    Publication number: 20080044401
    Abstract: Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: August 28, 2007
    Publication date: February 21, 2008
    Inventors: Chaitan Khosla, Kihang Choi
  • Enzyme treatment of foodstuffs for Celiac Sprue
    Patent number: 7320788
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: January 22, 2008
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Celiac Sprue Research Foundation
    Inventors: Lu Shan, Michael Bethune, Chaitan Khosla, Jonathan Gass, Gail G. Pyle, Gary Gray
  • Method to prepare macrolide analogs
    Publication number: 20080003648
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds.
    Type: Application
    Filed: December 10, 2003
    Publication date: January 3, 2008
    Inventors: Chaitan Khosla, Camilla Kao
  • Recombinant production of novel polyketides
    Patent number: 7312048
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: December 25, 2007
    Assignees: The Board of Trustees of the Leland Stanford University, The John Innes Institute
    Inventors: Chaitan Khosla, David A. Hopwood, Susanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla M. Kao
  • Enzyme treatment of foodstuffs for Celiac Sprue
    Patent number: 7303871
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: December 4, 2007
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Drug therapy for Celiac Sprue
    Patent number: 7265093
    Abstract: Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: September 4, 2007
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Kihang Choi
  • Drug therapy for Celiac Sprue
    Publication number: 20070161572
    Abstract: Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an immune response thereto are decreased by administration of an HLA-binding peptide inhibitor. Such inhibitors are analogs of immunogenic gluten peptides and (i) retain the ability to bind tightly to HLA molecules; (ii) retain the proteolytic stability of these peptides; but (iii) are unable to activate disease-specific T cells.
    Type: Application
    Filed: March 2, 2007
    Publication date: July 12, 2007
    Inventors: Ludvig Sollid, Chaitan Khosla, Hanne Quarsten, Chu-Young Kim
  • Production of polyketides
    Publication number: 20070092954
    Abstract: Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
    Type: Application
    Filed: August 8, 2005
    Publication date: April 26, 2007
    Inventors: Robert Arslanian, Gary Ashley, Scott Frykman, Bryan Julien, Leonard Katz, Chaitan Khosla, Janice Lau, Peter Licari, Rika Regentin, Daniel Santi, Li Tang
  • Drug therapy for celiac sprue
    Patent number: 7202216
    Abstract: Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an immune response thereto are decreased by administration of an HLA-binding peptide inhibitor. Such inhibitors are analogs of immunogenic gluten peptides and (i) retain the to bind tightly to HLA molecules; (ii) retain the protcolytic stability of these peptides; but (iii) are unable to T cells.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: April 10, 2007
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ludvig M. Sollid, Chaitan Khosla, Hanne Quarsten, Chu-Young Kim
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 7129071
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 31, 2006
    Assignee: KOSAN Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Diagnostic method for celiac sprue
    Publication number: 20060240475
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
    Type: Application
    Filed: November 20, 2003
    Publication date: October 26, 2006
    Inventors: Chaitan Khosla, Lu Shan
  • Production of polyketides
    Publication number: 20060223151
    Abstract: Recombinant host cells of the suborder Cystobacterineae containing recombinant expression vectors that encode heterologous PKS genes can produce polyketides synthesized by the PKS enzymes encoded on those vectors at high levels.
    Type: Application
    Filed: September 20, 2005
    Publication date: October 5, 2006
    Applicant: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla
  • Modified modular polyketide synthase
    Patent number: 7101684
    Abstract: Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: September 5, 2006
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David Cane
  • Peptides for diagnostic and therapeutic methods for celiac sprue
    Publication number: 20060189540
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
    Type: Application
    Filed: August 4, 2005
    Publication date: August 24, 2006
    Inventors: Chaitan Khosla, Jiang Xia, Matthew Siegel
  • host cells containing heterologous PKS genes for the synthesis of polykedtides
    Patent number: 7067286
    Abstract: Recombinant host cells of the suborder Cystobacterineae, genus Stizmatella, containing recombinant expression vectors that encode heterologous epothilone polyketide synthase (PKS) genes and can produce epothilones at high levels are provided.
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: June 27, 2006
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla
  • Polyketide synthase enzymes and recombinant DNA constructs therefor
    Patent number: RE39762
    Abstract: Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: August 7, 2007
    Assignee: Kosan Biosciences, Inc.
    Inventors: Christopher Reeves, Daniel Chu, Chaitan Khosla, Daniel Santi, Kai Wu