Abstract: The present disclosure relates to a formulations and methods for transdermal delivery of a medicament through the skin of a subject. In aspects, the formulation comprises a therapeutically effective amount of a medicament and a penetrant portion in which the penetrant portion comprises: a phospholipid, a fatty acid ester formed from a low molecular weight alcohol, and a long-chain fatty acids. In some embodiments, the penetrant portion further comprises one or more of a viscosity-improving agent, a penetration enhancer, and an emulsifier.

Abstract: Systems and methods for network-based communication techniques using an enhanced communication protocol. An example method includes receiving, from a first user device, a registration message comprising a plurality of communication paths over which the first user device is accessible, the communications paths indicating respective IP address/port pairs associated with the first user device, wherein information in the registration message is provided according to the session initiation protocol (SIP); setting a particular communication path as the preferred communication path for the first user device; and establishing a SIP connection between the first user device and the second user device, wherein SIP messages are routed from the second user device to the first user device via the particular communication path.

Abstract: A wireless device capable of using multiple SIM cards to simultaneously communicate with multiple cellular networks is presented. The wireless device is a dual-SIM dual-data active device that is capable of receiving and transmitting data packets over multiple cellular networks simultaneously or at substantially the same time. The wireless device may include a second set of antennas and internal hardware, including a second model and processor enabling the wireless device to communicate with at least two cellular networks. The wireless device may select a cellular network to perform a task, such as complete a call or download a video based on a difference in signal strength between the two or more cellular networks supported by the wireless device.

Abstract: A system for selecting communication routes based on multiple criteria may allow users to configure call routing systems to dynamically route calls by performing one or more of: ranking call destinations (e.g., vendors or trunk locations), adjusting or replacing route groups, queuing calls, activating interactive voice responses (IVRs), and re-purposing ports and trunks.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to an handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to an handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: A system for selecting communication routes based on multiple criteria is disclosed. The system can dynamically update route ranking criteria without loading new data tables. Further, the system can be implemented in the context of a route ranking system that provides a list of routes for processing or completing a call. The list of routes can be generated in a ranked order to facilitate attempts to route the call based on the predefined routing criteria. Further, the route ranking system can determine the list of routes based on one or more criteria including, for example, margins, call type, and vendor ratings, to name a few. Advantageously, modifications can be made to values associated with the routing criteria without requiring the loading of new tables associated with the routing criteria. These modifications can be associated with an expiration condition thereby enabling increased flexibility in determining the list of routes.

Abstract: A method and system of allocating an interest in mineral rights. The method comprises receiving, in a memory of the server computing device, a set of land tract boundary data and a set of spacing unit boundary data from a plurality of data sources; defining, in a processor of the server computing device, based on standardizing the sets of land tract boundary data and spacing unit boundary data, a land tract polygon and a spacing unit polygon, the land tract and spacing unit polygons representing geo-located areas bounding a land tract and a spacing unit respectively; determining, in the processor, an intersection area defined in common between the land tract polygon and the spacing unit polygon; and allocating the interest in mineral rights based at least partly on the intersection area, an expected royalty rate, and an allocation factor attributable to at least one of a plurality of contributing sources associated with the mineral right.

Abstract: Systems and methods for network-based communication techniques using an enhanced communication protocol. An example method includes receiving, from a first user device, a registration message comprising a plurality of communication paths over which the first user device is accessible, the communications paths indicating respective IP address/port pairs associated with the first user device, wherein information in the registration message is provided according to the session initiation protocol (SIP); setting a particular communication path as the preferred communication path for the first user device; and establishing a SIP connection between the first user device and the second user device, wherein SIP messages are routed from the second user device to the first user device via the particular communication path.

Abstract: A system for selecting communication routes based on multiple criteria is disclosed. Disclosed in the present application are a number of systems and associated processes for allowing users to configure call routing systems to dynamically route calls by performing one or more of: ranking call destinations (e.g., vendors or trunk locations), adjusting or replacing route groups, queuing calls, activating interactive voice responses (IVRs), and re-purposing ports and trunks.

Abstract: A wireless device capable of using multiple SIM cards to simultaneously communicate with multiple cellular networks is presented. The wireless device is a dual-SIM dual-data active device that is capable of receiving and transmitting data packets over multiple cellular networks simultaneously or at substantially the same time. The wireless device may include a second set of antennas and internal hardware, including a second model and processor enabling the wireless device to communicate with at least two cellular networks. The wireless device may select a cellular network to perform a task, such as complete a call or download a video based on a difference in signal strength between the two or more cellular networks supported by the wireless device.

Abstract: The present disclosure concerns recombinant yeast host cell for saccharification of a biomass. The recombinant yeast host cell has a genetic modification for expressing a heterologous polypeptide having glucoamylase activity (Rasamsonia emersonii glucoamylase). In some embodiments, the heterologous polypeptide comprises the signal sequence associated with the alpha-mating 1 factor. The present disclosure also concerns a process for saccharification of a biomass using the recombinant yeast host cell as well as a process for fermenting the saccharified biomass into a fermentation product.

Abstract: This disclosure describes a method to induce HBV infection in cells or animal models with an HBV pregenomic RNA (pgRNA). The method is amenable to multiple genotypes and has excellent signal-to-noise ratios. The method can be used to identify novel anti-HBV agents, measure anti-HBV drug efficiency, and predict drug resistance.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to a handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to a handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: A neutron detector including a plurality of layers of converter material and a plurality of layers of detector material. Each layer of converter material can be immediately adjacent to at least one layer of detector material and each layer of detector material can be immediately adjacent to at least one layer of converter material. The neutron detector may further include a read out integrated circuit (ROIC) that is electrically coupled to the plurality of layers of detector material. A value output by the ROIC may be indicative of a neutron interacting with a layer of converter material from amongst the plurality of layers of converter material.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to a handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: A method and system of allocating an interest in mineral rights. The method comprises receiving, in a memory of the server computing device, a set of land tract boundary data and a set of spacing unit boundary data from a plurality of data sources; defining, in a processor of the server computing device, based on standardizing the sets of land tract boundary data and spacing unit boundary data, a land tract polygon and a spacing unit polygon, the land tract and spacing unit polygons representing geo-located areas bounding a land tract and a spacing unit respectively; determining, in the processor, an intersection area defined in common between the land tract polygon and the spacing unit polygon; and allocating the interest in mineral rights based at least partly on the intersection area, an expected royalty rate, and an allocation factor attributable to at least one of a plurality of contributing sources associated with the mineral right.

Abstract: The present disclosure concerns a process for fermenting a biomass with a reduced dose of a purified exogenous enzyme (which can be, for example a purified exogenous glucoamylase). The process comprises contacting a biomass (which may comprise starch) with a recombinant yeast host cell. The recombinant yeast host cell has a genetic modification for expressing a heterologous polypeptide having starch or dextrin hydrolase activity (which may be, for example, from a glucoamylase). The nucleic acid molecule encoding the heterologous polypeptide having starch or dextrin hydrolase activity comprises allowing the secretion of the heterologous polypeptide.

Abstract: The present disclosure concerns recombinant yeast host cell for saccharification of a biomass. The recombinant yeast host cell has a genetic modification for expressing a heterologous polypeptide having glucoamylase activity (Rasamsonia emersonii glucoamylase). In some embodiments, the heterologous polypeptide comprises the signal sequence associated with the alpha-mating 1 factor. The present disclosure also concerns a process for saccharification of a biomass using the recombinant yeast host cell as well as a process for fermenting the saccharified biomass into a fermentation product.