Abstract: A wireless device capable of using multiple SIM cards to simultaneously communicate with multiple cellular networks is presented. The wireless device is a dual-SIM dual-data active device that is capable of receiving and transmitting data packets over multiple cellular networks simultaneously or at substantially the same time. The wireless device may include a second set of antennas and internal hardware, including a second model and processor enabling the wireless device to communicate with at least two cellular networks. The wireless device may select a cellular network to perform a task, such as complete a call or download a video based on a difference in signal strength between the two or more cellular networks supported by the wireless device.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to an handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: A wireless device capable of using multiple SIM cards to simultaneously communicate with multiple cellular networks is presented. The wireless device is a dual-SIM dual-data active device that is capable of receiving and transmitting data packets over multiple cellular networks simultaneously or at substantially the same time. The wireless device may include a second set of antennas and internal hardware, including a second model and processor enabling the wireless device to communicate with at least two cellular networks. The wireless device may select a cellular network to perform a task, such as complete a call or download a video based on a difference in signal strength between the two or more cellular networks supported by the wireless device.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to an handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: A wireless device capable of using multiple SIM cards to simultaneously communicate with multiple cellular networks is presented. The wireless device is a dual-SIM dual-data active device that is capable of receiving and transmitting data packets over multiple cellular networks simultaneously or at substantially the same time. The wireless device may include a second set of antennas and internal hardware, including a second model and processor enabling the wireless device to communicate with at least two cellular networks. The wireless device may select a cellular network to perform a task, such as complete a call or download a video based on a difference in signal strength between the two or more cellular networks supported by the wireless device.

Abstract: A system for selecting communication routes based on multiple criteria is disclosed. The system can dynamically update route ranking criteria without loading new data tables. Further, the system can be implemented in the context of a route ranking system that provides a list of routes for processing or completing a call. The list of routes can be generated in a ranked order to facilitate attempts to route the call based on the predefined routing criteria. Further, the route ranking system can determine the list of routes based on one or more criteria including, for example, margins, call type, and vendor ratings, to name a few. Advantageously, modifications can be made to values associated with the routing criteria without requiring the loading of new tables associated with the routing criteria. These modifications can be associated with an expiration condition thereby enabling increased flexibility in determining the list of routes.

Abstract: A system for updating a database having a size limit is disclosed. The system can dynamically update a table associated with a given call destination based on historical call data associated with the given call destination. The database may specify a size limit on the table (e.g., the number of database entries the table can include, which may depend on the sizes of the individual database entries) associated with each call destination. The system can generate a number of database entries that would satisfy the size limit based on the historical call data and the carrier data associated with a plurality of carriers that may be used to route the calls made to the call destination and insert the generated database entries into the database.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to an handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: A wireless device capable of using multiple SIM cards to simultaneously communicate with multiple cellular networks is presented. The wireless device is a dual-SIM dual-data active device that is capable of receiving and transmitting data packets over multiple cellular networks simultaneously or at substantially the same time. The wireless device may include a second set of antennas and internal hardware, including a second model and processor enabling the wireless device to communicate with at least two cellular networks. The wireless device may select a cellular network to perform a task, such as complete a call or download a video based on a difference in signal strength between the two or more cellular networks supported by the wireless device.

Abstract: An apparatus for passing one or more sutures in tissue repair and/or other surgical procedures. The apparatus includes a pair of jaws mounted on a distal end of a shaft, a hand assembly mounted on a proximal end of the shaft, and a curved needle mounted on the hand assembly and through a shaft. The curved needle remains within the jaw assembly and can be actuated out of the jaw assembly without deformation of the needle and by linear advancement of a needle linkage.

Abstract: A wireless device capable of using multiple SIM cards to simultaneously communicate with multiple cellular networks is presented. The wireless device is a dual-SIM dual-data active device that is capable of receiving and transmitting data packets over multiple cellular networks simultaneously or at substantially the same time. The wireless device may include a second set of antennas and internal hardware, including a second model and processor enabling the wireless device to communicate with at least two cellular networks. The wireless device may select a cellular network to perform a task, such as complete a call or download a video based on a difference in signal strength between the two or more cellular networks supported by the wireless device.

Abstract: A quick loader assembly for loading a breech loading or muzzle loading rifle includes a rifle that has a breech loader and the breech loader has an open end. A tube is include and a plurality of bullets is slidably positionable in the tube for loading the rifle. The tube is insertable into the open end of the breech loader thereby facilitating the bullets to be slid into the breech loader. A first cap is slidably positionable on the tube to close the tube thereby retaining the bullets within the tube.

Abstract: A system for selecting communication routes based on multiple criteria is disclosed. The system can dynamically update route ranking criteria without loading new data tables. Further, the system can be implemented in the context of a route ranking system that provides a list of routes for processing or completing a call. The list of routes can be generated in a ranked order to facilitate attempts to route the call based on the predefined routing criteria. Further, the route ranking system can determine the list of routes based on one or more criteria including, for example, margins, call type, and vendor ratings, to name a few. Advantageously, modifications can be made to values associated with the routing criteria without requiring the loading of new tables associated with the routing criteria. These modifications can be associated with an expiration condition thereby enabling increased flexibility in determining the list of routes.

Abstract: A system for updating a database having a size limit is disclosed. The system can dynamically update a table associated with a given call destination based on historical call data associated with the given call destination. The database may specify a size limit on the table (e.g., the number of database entries the table can include, which may depend on the sizes of the individual database entries) associated with each call destination. The system can generate a number of database entries that would satisfy the size limit based on the historical call data and the carrier data associated with a plurality of carriers that may be used to route the calls made to the call destination and insert the generated database entries into the database.

Abstract: An apparatus for passing one or more sutures in tissue repair and/or other surgical procedures. The apparatus includes a pair of jaws mounted on a distal end of a shaft, a hand assembly mounted on a proximal end of the shaft, and a curved needle mounted on the hand assembly and through a shaft. The curved needle remains within the jaw assembly and can be actuated out of the jaw assembly without deformation of the needle and by linear advancement of a needle linkage.

Abstract: An apparatus for passing one or more sutures in tissue repair and/or other surgical procedures. The apparatus includes a pair of jaws mounted on a distal end of a shaft, a hand assembly mounted on a proximal end of the shaft, and a curved needle mounted on the hand assembly and through a shaft. The curved needle remains within the jaw assembly and can be actuated out of the jaw assembly without deformation of the needle and by linear advancement of a needle linkage.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: An apparatus for passing one or more sutures in tissue repair and/or other surgical procedures. The apparatus includes a pair of jaws mounted on a distal end of a shaft, a hand assembly mounted on a proximal end of the shaft, and a curved needle mounted on the hand assembly and through a shaft. The curved needle remains within the jaw assembly and can be actuated out of the jaw assembly without deformation of the needle and by linear advancement of a needle linkage.

Abstract: Thermophilic gram-positive anaerobic host cells, for example Thermoanaerobacterium saccharolyticum (“T sacch”), express heterologous biomass degrading enzymes, such as cellulases, and are able to produce useful fermentation products from cellulose. Useful fermentation products include, for example, ethanol, acetic acid, lactic acid or CO2. In order to provide maximum expression and activity levels, biomass degrading enzymes can be expressed from codon-optimized nucleotide sequences, can be expressed under the control of a high-efficiency promoter, and/or can be fused to a signal peptide. In addition, the host cell, for example, a T sacch host cell, can be genetically altered to further improve ethanol production, for example by disrupting the production of organic products other than ethanol.