Abstract: A DNA molecule is provided which encodes a polypeptide which is capable of binding human TNF.alpha. and which has the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of a receptor selected from the 55 kD and 75 kD receptors for human TNF.alpha.. The ability of the polypeptide to bind to TNF.alpha. means that it can be used for treating diseases mediated by TNF.alpha. activity, such as rheumatoid arthritis.

Abstract: A method of forming a capacitor includes, a) providing a substrate; b) etching into the substrate to provide a depression in the substrate, the depression having a sidewall which is angled from vertical; c) providing a conformal layer of hemispherical grain polysilicon within the depression and over the angled sidewall, the layer of hemispherical grain polysilicon less than completely filling the depression; and d) ion implanting the hemispherical grain polysilicon layer with a conductivity enhancing impurity. Preferred methods of providing the depression where the substrate comprises SiO.sub.2 include a dry, plasma enhanced, anisotropic spacer etch utilizing reactant gases of CF.sub.4 and CHF.sub.3 provided to the substrate at a volumetric ratio of 1:1, and facet sputter etching.

Abstract: A method of forming a capacitor includes, a) providing a substrate; b) etching into the substrate to provide a depression in the substrate, the depression having a sidewall which is angled from vertical; c) providing a conformal layer of hemispherical grain polysilicon within the depression and over the angled sidewall, the layer of hemispherical grain polysilicon less than completely filling the depression; and d) ion implanting the hemispherical grain polysilicon layer with a conductivity enhancing impurity. Preferred methods of providing the depression where the substrate comprises SiO.sub.2 include a dry, plasma enhanced, anisotropic spacer etch utilizing reactant gases of CF.sub.4 and CHF.sub.3 provided to the substrate at a volumetric ratio of 1:1, and facet sputter etching.

Abstract: An improved wheel construction includes a disc and a rim secured together and which define a radially inwardly facing circumferential cavity in the wheel. In accordance with the present invention, a filler material is disposed in a substantial portion of the cavity to prevent road material or other debris from accumulating in the cavity and causing an out-of-balance wheel condition.

Abstract: A method of forming a capacitor includes, a) providing a substrate; b) etching into the substrate to provide a depression in the substrate, the depression having a sidewall which is angled from vertical; c) providing a conformal layer of hemispherical grain polysilicon within the depression and over the angled sidewall, the layer of hemispherical grain polysilicon less than completely filling the depression; and d) ion implanting the hemispherical grain polysilicon layer with a conductivity enhancing impurity. Preferred methods of providing the depression where the substrate comprises SiO.sub.2 include a dry, plasma enhanced, anisotropic spacer etch utilizing reactant gases of CF.sub.4 and CHF.sub.3 provided to the substrate at a volumetric ratio of 1:1, and facet sputter etching.

Abstract: A method of forming an electrically conductive polysilicon capacitor plate on a semiconductor substrate includes: a) providing a first layer of conductively doped polysilicon atop a semiconductor substrate to a first selected thickness; b) providing a thin layer of oxide atop the first polysilicon layer to a thickness of from about 2 Angstroms to about 30 Angstroms, the thin oxide layer having an outwardly exposed surface; and c) providing a second layer of conductively doped polysilicon having an outer exposed surface over the outwardly exposed thin oxide surface, the first polysilicon layer being electrically conductive with the second polysilicon layer through the thin layer of oxide, the second polysilicon layer having a second thickness from about 500 Angstroms to about 700 Angstroms, the thin oxide layer reducing silicon atom mobility during polysilicon deposition to induce roughness into the outer exposed polysilicon surface.