Patents by Inventor Chengrong Wang

Chengrong Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbonate ionophore with improved selectivity
    Patent number: 6391175
    Abstract: The invention pertains to a novel ionophore having the general structure: wherein R1, R2, R3 and R4 are independently straight or branched chain alkyl having 4 to 12 carbon atoms or the alkyl groups may optionally contain a cycloalkyl group having 3 to 8 carbon atoms or R1 and R2 or R3 and R4 together with N to which they are attached, can form a ring having 5 to 8 carbon atoms. This ionophore has increased selectivity for carbonate ions over other ions, especially salicylate. The invention includes membranes containing effective amounts of the novel ionophores and -sensors containing these membranes.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: May 21, 2002
    Assignee: Dade Behring Inc.
    Inventors: Chengrong Wang, Daniel Brown
  • Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group
    Patent number: 6231982
    Abstract: The invention is directed to the preparation of magnetic and non-magnetic particles coated with a polyaldehyde dextran material and a process for making the same. The polyaldehyde dextran coated particles of the invention are suitable for use in immunological assays and exhibit a reduced matrix effect in such assays when compared to convention particles without a polyaldehyde dextran coating.
    Type: Grant
    Filed: December 10, 1997
    Date of Patent: May 15, 2001
    Assignee: Dade Behring Inc.
    Inventor: Chengrong Wang
  • Cyclosporine derivatives and uses thereof
    Patent number: 6207398
    Abstract: The present invention provides novel cyclosporine C (CsC) derivatives having improved protein conjugatibility and hydrolytic stability. The present invention further provides a CsC derivative conjugated to a carrier, e.g., a solid support. Preferably, the solid support is a latex or magnetic particle.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: March 27, 2001
    Assignee: Dade Behring Inc.
    Inventor: Chengrong Wang
  • Chloride ion selective membrane electrode having improved stability and selectivity
    Patent number: 6015480
    Abstract: A method for extending the uselife of a chloride ion selective membrane of an ISE sensor by providing a two-layer sensor structure wherein an quaternized ion-selective polymeric layer is positioned between a sample to be analyzed and a conventional polymeric ISE membrane containing an ion-exchange agent. Also provided are polymer compositions comprised methyl methacrylate/choloromethyl styrene copolymer and mixtures thereof that have been reacted with tertiary amines.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: January 18, 2000
    Assignee: Dade Behring Inc.
    Inventors: Alan Robert Craig, Michael Patrick Reidy, Chengrong Wang
  • Cyclosporine derivatives and uses thereof
    Patent number: 5990274
    Abstract: The present invention provides novel cyclosporine C (CsC) derivatives having improved protein conjugatibility and hydrolytic stability. The present invention further provides a CsC derivative conjugated to a carrier, e.g., a solid support. Preferably, the solid support is a latex or magnetic particle.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: November 23, 1999
    Assignee: Dade Behring Inc.
    Inventor: Chengrong Wang
  • Method for measuring carbamazepine in human serum
    Patent number: 5851779
    Abstract: The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C=O, CH.sub.2 or SO.sub.2 ; Y is C=O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: December 22, 1998
    Assignee: Dade Behring Inc.
    Inventor: Chengrong Wang
  • Method for making carbamazephine derivative
    Patent number: 5852199
    Abstract: The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C.dbd.O, CH.sub.2 or SO.sub.2 ; Y is C.dbd.O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: December 22, 1998
    Assignee: Dade Behring Inc.
    Inventor: Chengrong Wang
  • Carbamazepine derivatives used in particle reagents
    Patent number: 5830768
    Abstract: The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C.dbd.O, CH.sub.2 or SO.sub.2 ; Y is C.dbd.O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: November 3, 1998
    Assignee: Dade Behring Inc.
    Inventor: Chengrong Wang
  • Carbamazepine derivatives/antigens
    Patent number: 5821342
    Abstract: The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C=O, CH.sub.2 or SO.sub.2 ; Y is C=O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: October 13, 1998
    Assignee: Dade Behring Inc.
    Inventor: Chengrong Wang
  • Carbamazepine derivatives
    Patent number: 5688944
    Abstract: The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C.dbd.O, CH.sub.2 or SO.sub.2 ; Y is C.dbd.O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Dade International Inc.
    Inventor: Chengrong Wang
  • Monensin amides for sodium-selective electrodes
    Patent number: 5522978
    Abstract: This invention relates to sodium-selective agents which are monensin amide derivatives and sodium-selective electrodes having sodium-selective membranes containing such monensin amide derivatives. This invention further relates to multisensor flow assemblies incorporating such a monensin amide derivative in a sodium-selective electrode.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: June 4, 1996
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Salvatore J. Pace, Chengrong Wang