Abstract: A close-loop deep brain stimulation algorithm system for Parkinson's disease includes a memory and a processor. The processor includes a deep brain stimulation (DBS) simulation module, a virtual brain network module, a feature extraction module, and a reinforcement learning module. The deep brain stimulation simulation module is adapted to combine a deep brain stimulation waveform according to the stimulation frequency and the stimulation amplitude and output the deep brain stimulation waveform. The virtual brain network module is adapted to receive the deep brain stimulation waveform to output a synaptic signal and calculate a reward parameter. The feature extraction module is adapted to receive the synaptic signal and extract a plurality of feature values according to the synaptic signal.

Abstract: A neuromodulation probe includes a body and at least one coil set. The body has a first axis and a length along the first axis. The at least one coil set includes at least one coil, and the at least one coil is formed by winding spirally a conductive wire plural times about a second axis inside the body or on an outer surface of the body. The second axis is parallel to the first axis. The at least one coil has two opposite wire ends for providing an electric current to flow in or out of the at least one coil.

Abstract: A state assessment system, a diagnosis and treatment system and a method for operating the diagnosis and treatment system are disclosed. An oscillator model converts a physiological signal of a subject into a defined feature image. A classification model analyzes state information of the subject based on the feature image. An analysis model outputs a treatment suggestion for the subject based on the state information of the subject. An AR projection device projects acupoint positions of a human body onto the subject, for the subject to be treated based on the treatment suggestion.

Abstract: A neuromodulation probe includes a body and at least one coil set. The body has a first axis and a length along the first axis. The at least one coil set includes at least one coil, and the at least one coil is formed by winding spirally a conductive wire plural times about a second axis inside the body or on an outer surface of the body. The second axis is parallel to the first axis. The at least one coil has two opposite wire ends for providing an electric current to flow in or out of the at least one coil.

Abstract: A state assessment system, a diagnosis and treatment system and a method for operating the diagnosis and treatment system are disclosed. An oscillator model converts a physiological signal of a subject into a defined feature image. A classification model analyzes state information of the subject based on the feature image. An analysis model outputs a treatment suggestion for the subject based on the state information of the subject. An AR projection device projects acupoint positions of a human body onto the subject, for the subject to be treated based on the treatment suggestion.

Abstract: An electronic stimulation device is adapted for electrically stimulating a target zone of an organism with relative low pain sensations without generating relative much sensations of paresthesia. The electronic stimulation device comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode. The electronic stimulation unit receives a high-frequency electrical stimulation signal to impel the first electrode and the second electrode to generate an electric field. The range of the electric field covers the target zone, and the electric field strength ranges from 100 V/m to 1000 V/m. The frequency of the high-frequency electrical stimulation signal ranges from 200 KHz to 1000 KHz.

Abstract: An electronic stimulation device for electrically stimulating at least one dorsal root ganglion with relative low pain sensations without generating relative much sensations of paresthesia comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode, and it delivers a high-frequency electrical stimulation signal to impel the first electrode and the second electrode to generate an electric field. The range of the electric field covers the dorsal root ganglion, and the electric field strength ranges from 100 V/m to 1000 V/m.

Abstract: An electronic stimulation device for electrically stimulating at least one dorsal root ganglion with relative low pain sensations without generating relative much sensations of paresthesia comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode, and it delivers a high-frequency electrical stimulation signal to impel the first electrode and the second electrode to generate an electric field. The frequency of the high-frequency electrical stimulation signal ranges from 200 kHz to 1000 kHz.

Abstract: An external control device includes a human-computer interface, a first controller and a power transmitting unit. An implantable medical device includes a power receiving unit, a second controller and a second detector. A method for monitoring power supply comprises: producing a first magnetic field by the power transmitting unit; sensing the first magnetic field to produce a second magnetic field and converting it into a direct current by the power receiving unit; detecting a power value of the direct current by the second detector to output a detection signal to the second controller; outputting a status information to the external control device by the second controller according to the detection signal; and receiving the status information by the first controller. The first controller transmits an adjustment signal to the power transmitting unit if informed of the status information that the power value is not within a designate power range.

Abstract: The electromagnetic stimulation device contains at least a positive electrode and at least a negative electrode. An insulating gap having width of a first distance is maintained between the positive and negative electrodes. The positive and negative electrodes are at least at a second distance away from a nerve to be stimulated. A preset voltage is applied to the positive and negative electrodes so that a low-power, low-temperature, high-frequency electromagnetic field covering and stimulating the nerve is produced between the positive and negative electrodes. By the stimulation of the low-power, low-temperature, high-frequency electromagnetic field, the nerve's threshold is increased, the nerve's transmission capability is reduced, and therefore the nerve pain is effectively eased.

Abstract: A porous film microfluidic device includes a sample well, a porous film support structure, including a first, second, and third port, wherein the first port is connected to the sample well, a porous film is formed over the bottom of the porous film support structure, and a glass fiber film is formed between the porous film support structure and the porous film, a waste tank connected to the second port of the porous film support structure, wherein a water absorption element is disposed in the waste tank, a buffer solution tank connected to the third port of the porous film support structure and sealed by a sealing film, and a COC plastic prism disposed over the bottom of the porous film support structure. The COC plastic prism includes a metal film in contact with the porous film and a metal oxide layer formed over the COC plastic prism.

Abstract: A dielectric constant measurement circuit includes a dielectric constant sensor, an oscillator controlling circuit, a waveform converting circuit, and a counting readout circuit. The oscillator controlling circuit generates an oscillation waveform according to the response of the dielectric constant sensor to a dielectric material. The waveform converting circuit converts the oscillation waveform into frequency division square waves. The counting readout circuit includes a switching counter, a switching circuit, a reference current source, and a current integrator.

Abstract: The implantable medical device is for implantation into a patient's body and is wirelessly powered by an external control device. The implantable medical device is induced by an AC electromagnetic field of the external control device through an inductive coil. A rectifier converts the AC electromagnetic field into a DC current. A detector detects a voltage value of the DC current, and a processor produces a first piece of status information accordingly. A transceiver receives and relays the first piece of status information to the external control device so as to monitor the power consumption of the implantable medical device when it is wirelessly powered.

Abstract: An electronic stimulation device for electrically stimulating at least one dorsal root ganglion with relative low pain sensations without generating relative much sensations of paresthesia comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode, and it delivers a high-frequency electrical stimulation signal to impel the first electrode and the second electrode to generate an electric field. The frequency of the high-frequency electrical stimulation signal ranges from 200 kHz to 1000 kHz.

Abstract: An electronic stimulation device for electrically stimulating at least one dorsal root ganglion with relative low pain sensations without generating relative much sensations of paresthesia comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode, and it delivers a high-frequency electrical stimulation signal to impel the first electrode and the second electrode to generate an electric field. The range of the electric field covers the dorsal root ganglion, and the electric field strength ranges from 100 V/m to 1000 V/m.

Abstract: An electronic stimulation device is adapted for electrically stimulating a target zone of an organism with relative low pain sensations without generating relative much sensations of paresthesia. The electronic stimulation device comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode. The electronic stimulation unit receives a high-frequency electrical stimulation signal to impel the first electrode and the second electrode to generate an electric field. The range of the electric field covers the target zone, and the electric field strength ranges from 100 V/m to 1000 V/m. The frequency of the high-frequency electrical stimulation signal ranges from 200 KHz to 1000 KHz.

Abstract: An external control device includes a human-computer interface, a first controller and a power transmitting unit. An implantable medical device includes a power receiving unit, a second controller and a second detector. A method for monitoring power supply comprises: producing a first magnetic field by the power transmitting unit; sensing the first magnetic field to produce a second magnetic field and converting it into a direct current by the power receiving unit; detecting a power value of the direct current by the second detector to output a detection signal to the second controller; outputting a status information to the external control device by the second controller according to the detection signal; and receiving the status information by the first controller. The first controller transmits an adjustment signal to the power transmitting unit if informed of the status information that the power value is not within a designate power range.

Abstract: The implantable medical device is for implantation into a patient's body and is wirelessly powered by an external control device. The implantable medical device is induced by an AC electromagnetic field of the external control device through an inductive coil. A rectifier converts the AC electromagnetic field into a DC current. A detector detects a voltage value of the DC current, and a processor produces a first piece of status information accordingly. A transceiver receives and relays the first piece of status information to the external control device so as to monitor the power consumption of the implantable medical device when it is wirelessly powered.

Abstract: The electromagnetic stimulation device contains at least a positive electrode and at least a negative electrode. An insulating gap having width of a first distance is maintained between the positive and negative electrodes. The positive and negative electrodes are at least at a second distance away from a nerve to be stimulated. A preset voltage is applied to the positive and negative electrodes so that a low-power, low-temperature, high-frequency electromagnetic field covering and stimulating the nerve is produced between the positive and negative electrodes. By the stimulation of the low-power, low-temperature, high-frequency electromagnetic field, the nerve's threshold is increased, the nerve's transmission capability is reduced, and therefore the nerve pain is effectively eased.

Abstract: A dielectric constant measurement circuit includes a dielectric constant sensor, an oscillator controlling circuit, a waveform converting circuit, and a counting readout circuit. The oscillator controlling circuit generates an oscillation waveform according to the response of the dielectric constant sensor to a dielectric material. The waveform converting circuit converts the oscillation waveform into frequency division square waves. The counting readout circuit includes a switching counter, a switching circuit, a reference current source, and a current integrator.