Abstract: Interleukin-18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: This invention relates to antibodies or fragments thereof which interact with HER family of receptors, e.g., HER3 receptor. In particular, it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand-dependent and ligand-independent signal transduction; and allow ligand binding (e.g., neuregulin), while preventing ligand-induced activation of signal transduction. These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g., esophageal cancer). These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g., prostate or uterine weights) or to induce atrophy of tissue (e.g., atrophy of male breast).

Abstract: The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to complement component 5 (C5).

Abstract: Provided is a method for access control, performed by an access control apparatus, including obtaining access authorisation information that is communicated to the access control apparatus having at least one access authorization parameter and first check information; using at least the communicated access authorisation parameters, the communicated first check information and a second key from a key pair, which second key is stored in the access control apparatus, to perform a first check on whether the communicated first check information has been produced by performing cryptographic operations by means of access authorisation parameters corresponding to the communicated access authorisation parameters using at least one first key from the key pair, and deciding whether access can be granted, based on the first check delivers a positive result and it is established that at least one predefined set of the communicated access authorisation parameters respectively provides access authorisation.

Abstract: Provided is a locking unit for a housing, comprising at least two doors for locking each housing opening. The locking unit has a locking element module for each of the doors, and the module has at least one locking body and a locking drive for actuating the locking body. The locking drive has a common drive element for the locking element modules, which drive element can be moved about a displacement path, and which, in a first displacement position, brings the locking body, for only one of the doors or only a first group of doors, of the doors into an unlocking position, and in a second displacement position, brings the locking body for all doors into an unlocking position. The invention also relates to a housing comprising a locking unit of this type, and to a method for unlocking one or more doors of a housing of this type.

Abstract: Provided is a method for access control, performed by an access control apparatus, including obtaining access authorization information that is communicated to the access control apparatus having at least one access authorization parameter and first check information; using at least the communicated access authorization parameters, the communicated first check information and a second key from a key pair, which second key is stored in the access control apparatus, to perform a first check on whether the communicated first check information has been produced by performing cryptographic operations by means of access authorization parameters corresponding to the communicated access authorization parameters using at least one first key from the key pair, and deciding whether access can be granted, based on the first check delivers a positive result and it is established that at least one predefined set of the communicated access authorization parameters respectively provides access authorization.

Abstract: Provided is a housing with at least two doors for locking respective housing openings, comprising: a locking unit, which, for each of the doors, has a respective locking-element module with at least one locking body and with a locking drive for actuating the locking body, wherein the locking drive for the locking-element modules has a common drive element, which can be moved and moves the locking body/bodies for just one of the doors into an unlocking setting and, in a second adjustment position, moves the locking bodies for all of the doors into an unlocking setting; or locking units, wherein one or more respective locking units can be activated for unlocking the associated door of the at least two doors of the housing, and respective locking units can be activated for unlocking all of the associated doors of the at least two doors of the housing.

Abstract: A method having the steps of obtaining temporal information communicated to a first device; carrying out one or more of the following tests: a test to determine whether the first device is in a state following an initial operation, a battery replacement or other power outage, or a reset, a test to determine whether a deviation between temporal information of the clock and the communicated temporal information is less than or equal to a threshold which is specified, and a test to determine whether the communicated temporal information has the same date as the temporal information of the clock; and synchronizing the clock using the communicated temporal information if all of one or more defined conditions are satisfied, wherein one of the one or more conditions requires that at least one of the one or more tests carried out has a positive result.

Abstract: Provided is a method involving obtaining an identifier at a control unit of a compartment system having compartments provided with respective locks and respective lock control units that are configured to communicate with the control unit; obtaining information indicating that one compartment has been closed, and causing storing of the identifier in the lock control unit assigned to the compartment. Also provided is a method comprising detecting, at a lock control unit assigned to a compartment of a compartment system comprising a control unit and compartments provided with respective locks and lock control units configured to communicate with the control unit, that the compartment has been closed; transmitting a piece of information identifying the lock control unit to the control unit if it has been detected that the compartment has been closed; obtaining an identifier from the control unit; and storing the identifier in the lock control unit.

Abstract: IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: Provided is a locking unit for a housing, comprising at least two doors for locking each housing opening. The locking unit has a locking element module for each of the doors, said module having at least one locking body and a locking drive for actuating the locking body. The locking drive has a common drive element for the locking element modules, which drive element can be moved about a displacement path, and which, in a first displacement position, brings the locking body, for only one of the doors or only a first group of doors, of the doors into an unlocking position, and in a second displacement position, brings the locking body for all doors into an unlocking position. The invention also relates to a housing comprising a locking unit of this type, and to a method for unlocking one or more doors of a housing of this type.

Abstract: The invention relates to a method for deactivating the locking of at least one door of an accommodating device, said method comprising: effecting the unlocking of the at least one door, measuring the time since at least one event detected by an access-monitoring device of the accommodating device has occurred, and effecting, if the at least one door is open and the measured time exceeds a specified time threshold value, the deactivation of the locking of the at least one door in such a way that the at least one door cannot be locked. The invention further relates to an access-monitoring device, a computer program, an accommodating device, a system, and a use of the accommodating device.

Abstract: The disclosure relates to a method including the steps of: detection of a presence of an access authorization verification apparatus in surroundings of an access control apparatus by first communication means of the access control apparatus, and prompting, when the presence of the access authorisation verification apparatus in the surroundings of the access control apparatus is detected, of a change of operating mode for second communication means of the access control apparatus. In addition, the disclosure relates to an access control apparatus, a computer program, a recording apparatus, a system and a use for an access authorisation verification apparatus.

Abstract: Provided is a method, performed by an access authorisation verification apparatus, involving the steps of: obtaining a piece of information from a transmission; identifying a transmission data record using the piece of information obtained from the transmission, wherein the transmission data record comprises address information associated with the transmission; determining an access control apparatus on the basis of a comparison of the address information of the transmission data record with respective address information that is associated with the access control apparatuses and stored on the access authorisation verification apparatus; allowing selection and/or confirmation of an access control apparatus for the determined access control apparatus by a user of the access authorisation verification apparatus; and communicating access authorization information to the access control apparatus in order to gain access to a room associated with the access control apparatus, so that the transmission can be placed

Abstract: A method having the steps of obtaining temporal information communicated to a first device; carrying out one or more of the following tests: a test to determine whether the first device is in a state following an initial operation, a battery replacement or other power outage, or a reset, a test to determine whether a deviation between temporal information of the clock and the communicated temporal information is less than or equal to a threshold which is specified, and a test to determine whether the communicated temporal information has the same date as the temporal information of the clock; and synchronizing the clock using the communicated temporal information if all of one or more defined conditions are satisfied, wherein one of the one or more conditions requires that at least one of the one or more tests carried out has a positive result.

Abstract: Provided is a method for access control, performed by an access control apparatus, including obtaining access authorisation information that is communicated to the access control apparatus having at least one access authorization parameter and first check information; using at least the communicated access authorisation parameters, the communicated first check information and a second key from a key pair, which second key is stored in the access control apparatus, to perform a first check on whether the communicated first check information has been produced by performing cryptographic operations by means of access authorisation parameters corresponding to the communicated access authorisation parameters using at least one first key from the key pair, and deciding whether access can be granted, based on the first check delivers a positive result and it is established that at least one predefined set of the communicated access authorisation parameters respectively provides access authorisation.

Abstract: Provided is a housing with at least two doors for locking respective housing openings, comprising: a locking unit, which, for each of the doors, has a respective locking-element module with at least one locking body and with a locking drive for actuating the locking body, wherein the locking drive for the locking-element modules has a common drive element, which can be moved and moves the locking body/bodies for just one of the doors into an unlocking setting and, in a second adjustment position, moves the locking bodies for all of the doors into an unlocking setting; or locking units, wherein one or more respective locking units can be activated for unlocking the associated door of the at least two doors of the housing, and respective locking units can be activated for unlocking all of the associated doors of the at least two doors of the housing.

Abstract: Interleukin 18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: This invention relates to antibodies or fragments thereof which interact with HER family of receptors, e.g., HER3 receptor. In particular, it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand-dependent and ligand-independent signal transduction; and allow ligand binding (e.g., neuregulin), whilst preventing ligand-induced activation of signal transduction. These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g., esophageal cancer). These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g., prostate or uterine weights) or to induce atrophy of tissue (e.g., atrophy of male breast).

Abstract: This invention relates to antibodies or fragments thereof which interact with HER family of receptors, e.g., HER3 receptor. In particular, it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand-dependent and ligand-independent signal transduction; and allow ligand binding (e.g., neuregulin), while preventing ligand-induced activation of signal transduction. These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g., esophageal cancer). These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g., prostate or uterine weights) or to induce atrophy of tissue (e.g., atrophy of male breast).