Abstract: The present disclosure relates to an ophthalmological patient interface for application to an eye of a person, the ophthalmological patient interface comprising a coupling portion configured to be arranged on an application head of an ophthalmological laser treatment system, wherein the ophthalmological patient interface further comprises an eye fixation portion configured to be arranged on the eye, wherein the eye fixation portion comprises a cornea contacting element, configured to contact at least partially the cornea of the eye, and a sclera contacting element, configured to contact at least partially the sclera of the eye, wherein the cornea contacting element and the sclera contacting element define a rotationally asymmetric contact surface configured to contact the eye.

Abstract: A method is proposed for producing one or more electrolysis products, wherein one or more electrolytic cells having a proton exchange membrane is/are used, wherein a hydrogen-rich cathode extraction gas is extracted on the cathode side of the one or more electrolytic cells, wherein an anode extraction gas is extracted on the anode side of the one or more electrolytic cells, wherein the anode extraction gas is extracted from the one or more electrolytic cells as part of a two-phase flow, wherein the two-phase flow comprises the anode extraction gas and a water phase, and wherein the two-phase flow or part thereof is separated in a separator arrangement into the anode extraction gas and the water phase.

Abstract: A method performed by one or more devices includes determining an information item indicative of at least one parameter affecting the treatment of a textile with the information item being detected by an information carrier of the textile (220) and/or a cleaning device (230), or a cleaning agent (210) and the textile (220), or the cleaning agent (210) and the cleaning device, or the cleaning agent (210) and the textile (220) and the cleaning device and the information carrier comprises a package, a label, an NFC chip or a combination thereof, determining at least one treatment parameter of the textile based at least in part on the determined information item, and outputting or triggering the outputting of the at least one determined treatment parameter.

Abstract: An electronic unit, in particular for an electric fluid pump of a motor vehicle, having a functional element for holding electronics, and a heat sink arranged on the functional element, wherein the functional element and the heat sink are sealed from one another in fluid-tight fashion by means of a cured sealing compound of a liquid seal, and wherein the functional element has at least one ventilation opening, which is open in the course of a curing process for the sealing compound, and which, after the curing process, is sealed in fluid-tight fashion by means of a closure element.

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (111 1) and methods of treating Huntington's disease using the same.

Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

Abstract: One or more embodiments of the present invention relates to an energy supply circuit for a CT system. The energy supply circuit comprises a stationary energy distribution device, a co-rotating bias voltage supply device, a standard energy supply path having an energy transmission device between the stationary energy distribution device and the co-rotating bias voltage supply device and an alternatively connectable service energy supply path having a voltage protection device. A computed tomography system is also described. Further, a production method for producing an energy supply circuit for a CT system is described. In addition, a method for operating a CT system is described.

Abstract: Approaches, techniques, and mechanisms are disclosed for predicting molecular electronic structural information. According to one embodiment, quantum simulation results are generated for a molecule based on a quantum simulation of an electronic structure of the molecule. The quantum simulation of the electronic structure of the molecule is performed with quantum processing units. An input vector comprising data field values derived from the quantum simulation results for the molecule is created. An electronic structural information prediction model is applied to generate, based at least in part on the input vector, predicted electronic structural information for the molecule.

Abstract: Push actuated double fluid dispenser (1), comprising a container (2) having a first cavity (4a) and a second cavity (4b) separated from the cap first cavity (4a), and a dispensing pump device (6) in a general form of a cap assembled to the container over the first and second cavities, the dispensing pump device comprising a base part (7) and a cap part (8) including a pump mechanism (16) comprising an elastic flexible pump membrane (18) manually movable from an uncompressed state to a compressed state.

Abstract: The invention provides a polymer composition comprising (i) 25 to 84 wt % LDPE; (ii) 15 to 74 wt % of a polypropylene; and (iii) 1.0 to 20 wt % of a polyolefin (A) selected from the group consisting of a linear low density polyethylene (LLDPE), high density polyethylene (HDPE), polystyrene and polybutadiene.

Abstract: The invention provides a polymer composition comprising (i) 20 to 84 wt % LDPE; (ii) 15 to 75 wt % of a polypropylene; and (iii) 0.5 to 20 wt % of a styrene block copolymer.

Abstract: An optoelectronic device may include an optoelectronic semiconductor chip that is configured to emit electromagnetic radiation. The chip may include a first semiconductor layer, a second semiconductor layer, first and second current spreading structures, and a plurality of electrical contact elements. The first current spreading layer may be arranged on a side of the second semiconductor layer facing away from the first semiconductor layer. The plurality of electrical contact elements may electrically connect the first semiconductor layer to the first current spreading layer. The second current spreading layer may be electrically connected to the second semiconductor layer. The second current spreading layer may be arranged between the first current spreading layer and the second semiconductor layer where an insulating layer insulates a first electrical contact element and a second electrical contact element from the second current spreading layer.

Abstract: The invention relates to a motorized functional fitting (2; 4) for a box-spring bed, said functional fitting comprising: a longitudinal member (2.1; 4.1) extending in a longitudinal axis of the member; a longitudinal member (2.1; 4.1) rotatably connected in an articulated manner to said longitudinal member; an articulated upright framework (2.5; 4.5); and a linear drive (2.4; 4.4) that is connected to the longitudinal member (2.1; 4.1) and acts on the upright framework (2.5; 4.5). In order to simplify the design, according to the invention: the longitudinal member (2.1; 4.1) can be fastened to the frame (6) or the center plate (8); an inner end face of the longitudinal member (2.1; 4.1) is designed to be fastened directly or indirectly to the center plate (8) or to the frame side parts (6.1; 6.2); the drive is located laterally adjacent to the longitudinal member (2.4; 4.4); the upright framework (2.5; 4.5) is rotatably connected in an articulated manner to the longitudinal member (2.1; 4.

Abstract: A cable, preferably a power cable, comprising one or more conductors surrounded by at least one layer, wherein said layer comprises (i) 15 to 84.5 wt % low density polyethylene (LDPE); (ii) a polypropylene; and (iii) a styrene block copolymer; wherein the weight percentages are based on the layer as a whole.

Abstract: The invention provides a polymer composition comprising a) a polyethylene; and b) a conjugated aromatic polymer. The invention also relates to cables comprising said polymer composition and the use of the polymer composition in the manufacture of an insulation layer of cable.

Abstract: Systems, methods, and devices are described for enabling a user to import a library into a computer program under development. The library includes a data storage interface, one or more semantic objects, and one or more data manipulation or data analysis operations. A user is able to reference code of the library within the computer program under development to generate a dataset from data obtained via the data storage interface and associate the one or more semantic objects with the dataset to generate a semantically-annotated dataset. Systems, methods, and devices enable, based on the importing: the user to invoke a semantic-guided operation of the library that utilizes the semantically-annotated dataset to infer an aspect of a data manipulation or data analysis operation to be performed on the semantically-annotated dataset; or the suggestion of a data manipulation or data analysis operation to the user based on the semantically-annotated dataset.

Abstract: Aspects of the disclosure relate to recombinant gene editing complexes comprising a recombinant gene editing protein and guide RNA (gRNA) that specifically hybridizes to a region of a C90RF72 gene (e.g., a region flanking a G4C2 repeat or within a exonic region of the gene).

Abstract: In some aspects, the disclosure relates to compositions and methods useful for inhibiting SOD1 expression in cells (e.g., cells of a subject). In some embodiments, the disclosure describes isolated nucleic acids engineered to express an inhibitory nucleic acid targeting endogenous SOD1 and an mRNA encoding a hardened SOD1 protein. In some embodiments, compositions and methods described by the disclosure are useful for treating Amyotrophic Lateral Sclerosis (ALS) in a subject.