Abstract: Provided herein are methods for enhancing gene therapy in an individual by administering an IRAK modulator (e.g., an IRAK-4 degrader) with the gene therapy to suppress innate immunity to the gene therapy. In some embodiments, the gene therapy uses an adeno-associated virus (AAV) vector, an adenovirus vector, a lentivirus vector, a Herpes simplex virus (HSV) vector or a lipid nanoparticle. Also provided herein are methods for selecting an individual for treatment with an IRAK modulator in combination with a gene therapy agent.

Abstract: Proposed is a transfer system for presses, having at least two fastening units arranged opposite one another, wherein each of the fastening units in each case has a first fastening region. The transfer system further has a press transfer unit, consisting of two movement arms arranged opposite one another, as well as a crossbar connected thereto for receiving and for transporting, i.e. including setting down, a workpiece. Each of the movement arms has a first drive unit connected to the first fastening region, a first lever arm, a second drive unit, and a second lever arm. The first lever arm is connected at a first end thereof or between the first and a second end to the first drive unit, and at the second end thereof to the second drive unit. The second lever arm is rotatably connected at a first end thereof to the second drive unit, and is movably connected with a second end thereof to the crossbar.

Abstract: Performance degradation of an application that is caused by another computing process that shares infrastructure with the application is detected. The application and the other computing device may execute via different virtual machines hosted on the same computing device. To detect the performance degradation that is attributable to the other computing process, certain storage segments of a data storage (e.g., a cache) shared by the virtual machines is written with data. A pattern of read operations are then performed on the segments to determine whether an increase in read access time has occurred. Such a performance degradation is attributable to another computing process. After detecting the degradation, a metric that quantifies the detected degradation attributable to the other computing process is provided to an ML model, which determines the actual performance of the application absent the degradation attributable to the other computing process.

Abstract: The invention relates to a braking mechanism (10) for an electric drive motor (1), in particular a drive motor (2) comprising an armature shaft (5) that protrudes from a motor housing (2); the braking mechanism (10) comprises at least one braking element (17) and an energy store, the energy store permanently applying a braking power to a frictional surface of the braking element. The braking mechanism (10) is characterized in that the energy store and the braking element (17) are made of the same material as a single piece.

Abstract: In order to be able to load a forming tube channel, which stands very steeply and is open at a front and top on a longitudinal side, correctly by checking and, if necessary, changing position of a product piece in the forming tube channel, instead of sliding the new product piece from the outside on a support plate to the forming tube channel in the machine and dropping it into the forming tube channel, the entire forming tube channel is moved from a cutting position outward to a loading position, the product piece is inserted there and an entire transfer device in the form of one or more slides is moved back to the cutting position and locked there.

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.

Abstract: RNAs, such as miRNA and siRNA, and their use in treating complement-mediated disorders, are described.

Abstract: Proposed is a transfer system for presses, having at least two fastening units arranged opposite one another, wherein each of the fastening units in each case has a first fastening region. The transfer system further has a press transfer unit, consisting of two movement arms arranged opposite one another, as well as a crossbar connected thereto for receiving and for transporting, i.e. including setting down, a workpiece. Each of the movement arms has a first drive unit connected to the first fastening region, a first lever arm, a second drive unit, and a second lever arm. The first lever arm is connected at a first end thereof or between the first and a second end to the first drive unit, and at the second end thereof to the second drive unit. The second lever arm is rotatably connected at a first end thereof to the second drive unit, and is movably connected with a second end thereof to the crossbar.

Abstract: The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.

Abstract: Systems, methods, and devices are described for enabling a user to import a library into a computer program under development. The library includes a data storage interface, one or more semantic objects, and one or more data manipulation or data analysis operations. A user is able to reference code of the library within the computer program under development to generate a dataset from data obtained via the data storage interface and associate the one or more semantic objects with the dataset to generate a semantically-annotated dataset. Systems, methods, and devices enable, based on the importing: the user to invoke a semantic-guided operation of the library that utilizes the semantically-annotated dataset to infer an aspect of a data manipulation or data analysis operation to be performed on the semantically-annotated dataset; or the suggestion of a data manipulation or data analysis operation to the user based on the semantically-annotated dataset.

Abstract: In some aspects, the disclosure relates to compositions and methods useful for inhibiting SOD1 expression in cells (e.g., cells of a subject). In some embodiments, the disclosure describes isolated nucleic acids engineered to express an inhibitory nucleic acid targeting endogenous SOD1 and an mRNA encoding a hardened SOD1 protein. In some embodiments, compositions and methods described by the disclosure are useful for treating Amyotrophic Lateral Sclerosis (ALS) in a subject.

Abstract: Performance degradation of an application that is caused by another computing process that shares infrastructure with the application is detected. The application and the other computing device may execute via different virtual machines hosted on the same computing device. To detect the performance degradation that is attributable to the other computing process, certain storage segments of a data storage (e.g., a cache) shared by the virtual machines is written with data. A pattern of read operations are then performed on the segments to determine whether an increase in read access time has occurred. Such a performance degradation is attributable to another computing process. After detecting the degradation, a metric that quantifies the detected degradation attributable to the other computing process is provided to an ML model, which determines the actual performance of the application absent the degradation attributable to the other computing process.

Abstract: The present invention relates to a process for purifying a crude nitrogen-containing, sulfur-containing, halogen-containing pyrolysis oil originating from the pyrolysis of plastic waste, comprising (i) subjecting the crude pyrolysis oil to a treatment with a trapping agent selected from (a) an elemental metal of group 1, 2, 6, 7, 8, 9, 10, 11, 12, 13 of the IUPAC periodic table, a mixture or an alloy thereof; (b) an oxide of metals of group 1, 2, 6, 7, 8, 9, 10, 11, 12, 13 of the IUPAC periodic table or a mixture thereof; (c) an alkoxide of metals of group 1, 2 of the IUPAC periodic table or a mixture thereof; (d) a solid sorption agent as defined in the claims; or a combination of at least two trapping agents (a), (b), (c) or (d); (ii) separating the product obtained into a purified pyrolysis oil fraction having a reduced nitrogen, sulfur and halogen content in relation to the crude pyrolysis oil and a fraction comprising the trapping agent which has bound at least a part of the sulfur, nitrogen, halogen pre

Abstract: The present invention relates to an ethylene polymer composition comprising: (A) an ethylene polymer comprising epoxy-groups, and (B) a cross-linking agent comprising: (B1) an organo-metallic Lewis acid, and at least one of: (B2) a compound comprising at least one amino group; and (B3) a compound comprising at least one hydroxyl group.

Abstract: The present invention relates to a cross-linkable polyolefin composition comprising a first olefin polymer (A) comprising a first comonomer comprising epoxy groups, and a second olefin polymer (B) comprising a second comonomer comprising carboxylic acid groups and/or precursor thereof.

Abstract: An inclination compensating device for a carriage of a conveyor device for the horizontal transport of conveyed material, wherein a drive element is driven via the pivot drive, which drive element is fastened to an end of a pivot lever extending away from the inclination compensating element, which end is opposite the inclination compensating element, and which drive element has a drive axis arranged parallel or perpendicular to the pivot axis, wherein the drive element rolls on at least one guide, in particular extending equidistantly to the pivot axis, in particular in a force-locking or form-locking manner, which guide is mounted or formed on the holding frame.

Abstract: A polymer composition comprising: (i) at least 40 wt % LDPE; (ii) a polypropylene homopolymer; and (iii) a random heterophasic polypropylene copolymer.

Abstract: A communication device with an activated ring controller provided in both first and second subnetworks for data transmission in a redundantly operable communications network, which includes at least one first and one second subnetwork, which each include communication devices interconnected within a ring topology, wherein the subnetworks are interconnected via coupling line sections to which coupling communication devices are connected, where the coupling line section to which a selected coupling communication device is connected is operated as an inactive reserve coupling line section until a disruption occurs, whilst another coupling line section is operated as an active main coupling line section, where coupling communication devices connected to the main coupling line section transmit status datagrams to the selected coupling communication device which additionally include configuration information about whether the particular coupling communication device connected to the main coupling line section is an

Abstract: The invention provides a polyolefin composition comprising (i) a polyolefin (A) comprising epoxy groups; and (ii) a polyolefin (B) comprising carboxylic acid groups and/or precursors thereof, with the proviso that at least one of (A) and (B) is polyethylene. Preferably one of (A) and (B) is a low density polyethylene (LDPE) and the other is a polypropylene.

Abstract: The invention provides a polymer composition comprising a) a low density polyethylene (LDPE); and b) a conjugated aromatic polymer. The invention also relates to cables comprising said polymer composition and the use of the polymer composition in the manufacture of an insulation layer of cable.