Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genetic alterations. In particular, a method is provided for that includes obtaining a set of sequence reads. The sequence reads each include a single molecule barcode (SMB) sequence that is a non-random oligonucleotide sequence. The method further includes assigning the sequence reads to read groups according to a read group signature. The read group signature comprises an SMB sequence and a start and end position of a nucleic acid fragment from the circulating cell free sample nucleic acid. The sequence reads comprising start and end positions and an SMB sequence similar to the read group signature are assigned to a read group. The method further includes generating a consensus for each read group, and determining the presence or absence of a genetic alteration based on the consensus for each read group.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genomic nucleic acid instability and genomic nucleic acid stability.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for determining sequences of nucleotides for nucleic acid templates in a nucleic acid sample. The technology provide herein also relates in part to methods, processes, machines and apparatuses for counting nucleic acid templates. Nucleic acid templates of a sample are tagged with nonrandom oligonucleotide adapters that include predetermined non-randomly generated sequences. The use of these nonrandom oligonucleotide adapters provides an efficient method to reduce sequencing errors, and increase the sensitivity of detection of low-frequency single nucleotide alterations.

Abstract: Provided herein are devices and methods for extracting blood plasma from ultra-low volumes of blood. In some cases, the devices and methods use positive pressure to force a blood sample through a filter or a membrane. In some cases, the devices and methods use centrifugation to force a blood sample through a filter or a membrane. The devices and methods disclosed herein are suitable for the preparation of high-quality samples containing cell-free nucleic acids.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genomic nucleic acid instability and genomic nucleic acid stability. The method comprises providing a set of genomic portions each coupled to a copy number alteration quantification for a test sample, wherein the genomic portions comprises portions of a reference genome to which sequence reads obtained for nucleic acid from a test sample obtained from the subject have been mapped, and the copy number alteration quantification coupled to each genomic portion has been determined from a quantification of sequence reads mapped to the genomic portion; and determining, by a computing device, presence or absence of genomic instability for the subject according to the copy number alteration quantifications coupled to the genomic portions.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for determining sequences of nucleotides for nucleic acid templates in a nucleic acid sample. The technology provide herein also relates in part to methods, processes, machines and apparatuses for counting nucleic acid templates. Nucleic acid templates of a sample are tagged with nonrandom oligonucleotide adapters that include predetermined non-randomly generated sequences. The use of these nonrandom oligonucleotide adapters provides an efficient method to reduce sequencing errors, and increase the sensitivity of detection of low-frequency single nucleotide alterations.

Abstract: A for melting batch material includes a furnace equipped with a submerged burner, a system for supplying the submerged burner with fuel gas and with oxidizer, a system for supplying the furnace with raw material including fragments of mineral wool below the surface of the molten batch materials, a system for supplying the furnace with raw material including a vertical duct for receiving raw material through its upper side and for conveying this raw material downward toward the molten batch materials. The duct receives the combustion flue gases originating from the furnace and conveys them upward through the raw material in the duct. A system supports the solid raw material in the duct and is positioned above the surface of the molten batch material and retains the solid raw material in the duct and lets descending molten raw material pass through to fall into the molten batch material.

Abstract: Disclosed are methods of fiber spinning and polymer fibers that utilize multifunctional thiol and enes compounds. Also, the subject matter disclosed herein relates to uses of polymer fibers and articles prepared from such fibers.

Abstract: Glass fibers have a chemical composition that includes the following constituents, in a weight content that varies within the limits defined below: SiO2 50-70%, Al2O3 0-5%, CaO+MgO 0-7%, Na2O 5-15%, K2O 0-10%, BaO 2-10%, SrO 2-10%, ZnO <2%, and B2O3 5-15%.

Abstract: Mineral fibers have a chemical composition including the following constituents, as weight percentages: SiO2 30% to 50%, Al2O3 10% to 20%, CaO+MgO 20% to 35%, Na2O+K2O 1% to 10%, wherein the mineral fibers include a content of total iron, expressed as Fe2O3, of from 5% to 15% and a redox, which corresponds to the weight ratio between the content of ferrous iron, expressed as Fe2O3, and the total content of iron, expressed as Fe2O3, of less than 0.6.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for determining sequences of nucleotides for nucleic acid templates in a nucleic acid sample. The technology provide herein also relates in part to methods, processes, machines and apparatuses for counting nucleic acid templates. Nucleic acid templates of a sample are tagged with nonrandom oligonucleotide adapters that include predetermined non-randomly generated sequences. The use of these nonrandom oligonucleotide adapters provides an efficient method to reduce sequencing errors, and increase the sensitivity of detection of low-frequency single nucleotide alterations.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genetic alterations. In particular, a method is provided for that includes obtaining a set of sequence reads. The sequence reads each include a single molecule barcode (SMB) sequence that is a non-random oligonucleotide sequence. The method further includes assigning the sequence reads to read groups according to a read group signature. The read group signature comprises an SMB sequence and a start and end position of a nucleic acid fragment from the circulating cell free sample nucleic acid. The sequence reads comprising start and end positions and an SMB sequence similar to the read group signature are assigned to a read group. The method further includes generating a consensus for each read group, and determining the presence or absence of a genetic alteration based on the consensus for each read group.

Abstract: Glass fibers have a chemical composition that includes the following constituents, in a weight content that varies within the limits defined below: SiO2 50-70%, Al2O3 0-5%, CaO+MgO 0-7%, Na2O 5-15%, K2O 0-10%, BaO 2-10%, SrO 2-10%, ZnO<2%, and B2O3 5-15%.

Abstract: Disclosed are methods of fiber spinning and polymer fibers that utilize multifunctional thiol and enes compounds. Also, the subject matter disclosed herein relates to uses of polymer fibers and articles prepared from such fibers.

Abstract: Disclosed are methods of fiber spinning and polymer fibers that utilize multifunctional thiol and enes compounds. Also, the subject matter disclosed herein relates to uses of polymer fibers and articles prepared from such fibers.

Abstract: Mineral fibers have a chemical composition including the following constituents, as weight percentages: SiO2 30% to 50%, Al2O3 10% to 20%, CaO+MgO 20% to 35%, Na2O+K2O 1% to 10%, wherein the mineral fibers include a content of total iron, expressed as Fe2O3, of from 5% to 15% and a redox, which corresponds to the weight ratio between the content of ferrous iron, expressed as Fe2O3, and the total content of iron, expressed as Fe2O3, of less than 0.6.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genomic nucleic acid instability and genomic nucleic acid stability.

Abstract: A method for ordering block copolymers including forming a first layer having a first preference mode; and providing a reactive agent in selected regions of the first layer that modifies the selected regions to a second preference mode, wherein the selected regions define other regions of the first layer retaining the first preference mode thereby forming an alignment layer for block copolymers.

Abstract: A method for ordering block copolymers including forming a first layer having a first preference mode; and providing a reactive agent in selected regions of the first layer that modifies the selected regions to a second preference mode, wherein the selected regions define other regions of the first layer retaining the first preference mode thereby forming an alignment layer for block copolymers.

Abstract: An internal combustion burner including a combustion chamber supplied with fuel and with oxidant and at least two combustion devices supplied with oxidant and with fuel. Combining two combustion devices of distinct configurations, which respectively generate two distinct types of flames with a system for cooling the walls of the burner by introducing air along the walls, makes it possible to obtain a burner that supplies a combustion gas temperature of up to 1700° C., while at the same time being easily cooled and occupying very little space so that it can, for example, be housed in an existing installation used in the manufacture of rock wool or glass wool.