Abstract: A load cell includes an annular base unit where an axial height of the annular base unit is smaller than a diameter of the annular base unit. The annular base unit has a plurality of mounting portions. A plurality of strain gages are located in the plurality of mounting portions. The annular base unit includes a plurality of sections having a Young's modulus different from the Young's modulus of the material of the base unit.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: Methods of characterizing an analyte using a detector such as a nanopore and an enzyme are provided. One aspect features methods for characterizing a double-stranded polynucleotide using a detector, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: Methods and systems for facilitating a program with participating merchants and consumers are described. In some embodiments, a method includes receiving a wish list of a user. The wish list may include items or services sold by merchants participating in the program. The wish list may be published to the merchants participating in the program. A location of the user may be determined, and an offer from one of the participating merchants may be received, where the offer is based on the location of the user. A total cost of the offer may be calculated by analyzing the offer. The user may be notified of the offer and the total cost.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods utilizing Meteorin-like (METRNL), C-X-C Motif Chemokine Receptor 6 (CXCR6) and/or endogenous C-X-C Motif Ligand 16 (CXCL16) as immune-oncology targets. Accordingly, in one aspect, the present invention provides compositions and methods directed to the knockout of METRNL, CXCR6 and/or CXCL16 expression in a cell. In particular embodiments, the cell is a T cell. In a specific embodiment, the present invention provides an engineered T-cell comprising disruption in the METRNL, CXCR6 and/or CXCL16 gene sequence. In another embodiment, an engineered T-cell comprises (a) at least one chimeric antigen receptor (CAR); and (b) at least one genomic disruption of METRNL, CXCR6 and/or CXCL16. In certain embodiments, the genomic disruption is performed using a CRSIPR endonuclease system.

Abstract: Methods and compositions for treating a glioblastoma (GBM) by administering a composition comprising a hydrogel and an anti-programmed cell death protein 1 (PD-1) antibody to one or more draining lymph nodes (DLNs) of a subject in need of treatment thereof are disclosed.

Abstract: Methods and systems for facilitating a program with participating merchants and consumers are described. In some embodiments, a method includes receiving a wish list of a user. The wish list may include items or services sold by merchants participating in the program. The wish list may be published to the merchants participating in the program. A location of the user may be determined, and an offer from one of the participating merchants may be received, where the offer is based on the location of the user. A total cost of the offer may be calculated by analyzing the offer. The user may be notified of the offer and the total cost.

Abstract: A portable mobile food preparation station has a body with a fillable water tank, a pump, a battery, a hose, silverware, a cutting board, a sink, and a task light. Retractable handles allow for a stovetop and the sink to be mounted to the sides of the body, allowing for access to the cutting board and silverware while using the stovetop, sink, or both. The task light, made of high-brightness LEDs, is placed on the inside of a hinged lid, and facilitates use of the food preparation station in low light conditions.

Abstract: Systems and methods to provide remote support services to a testing device are disclosed. An example testing device includes a computing device configured to obtain a measurement value related to the material or component under test. The computing device includes: a display; an input device; a processor; and a memory coupled to the processor and storing computer readable instructions which, when executed by the processor, cause the processor to: in response to first input via the input device, transmit a request for a technical support service to a remote computing system; perform, at the computing device, one or more remote service actions associated with the technical support service.

Abstract: A multi-stage object drop frac assembly that includes a fracture subassembly is configured for disposal in a well zone. The assembly includes a plurality of filtration media stages configured for disposal in the same well zone. A plurality of valves, one of the plurality of valves being associated with each of the plurality of filtration media stages is a part of the assembly and the plurality of valves are openable simultaneously in response to the same event.

Abstract: A frac dart includes a body having an outer surface and an end including at least one opening. A cutter support is mounted at the end adjacent the at least one opening. A cutter is moveably mounted at the cutter support. A counter support is slideably mounted on the outer surface, and a counter is arranged between the counter support and the cutter support. The cutter is operable to sever a portion of the counter.

Abstract: A system has a memory programmed with multiple firmware images each having an associated distinct entry point, a processor, a writable hardware register, and a controller external to the processor that, prior to each reset of a sequence of resets of the processor, reads the entry point of a firmware image from the hardware register and causes the processor to begin fetching instructions at the entry point read from the hardware register. The firmware images include boot, mission mode, and at least one other firmware image. The memory may be writeable with a modifiable version of a post-production mission mode, debug, prototype, or patched ROM firmware image. A second controller writes a second entry point to the hardware register prior to an initial reset such that the external controller reads the second entry point and causes fetching instructions at the second entry point rather than the initial entry point.

Abstract: A distributed processing system with multiple systems connected by an inter-system communication interface. Each system has a memory programmed with multiple firmware images each having a distinct entry point, a processor, a writable (by another system of the distributed processing system) hardware register initially seeded with an initial firmware image entry point, and a controller external to the processor that, prior to an initial reset, reads the entry point from the hardware register and causes the processor to begin fetching instructions at the initial entry point. Prior to a subsequent reset of the processor, the external controller facilitates a transition to another firmware image by reading its entry point from the hardware register and causing the processor to begin fetching instructions at the other entry point. Each system may have multiple processors and multiple associated hardware registers writeable by another processor of the system or a by host processor.

Abstract: A portable solar shower is a showering device that can heat the water in a tank to a user defined temperature, with the help of a large solar panel. In order to accomplish that, the device includes a thermostat that displays multiple temperatures, a vacuum insulated water tank that helps maintain the temperature of the water at the user defined temperature level for long hours, and a retractable showerhead and shower pipe. Further, the device is mounted over an upper surface of a vehicle, thereby not compromising any luggage or trunk space of the vehicle. The portable solar shower further includes a power unit that provides power to water pumps and all the necessary circuitry within the device. Furthermore, the device includes an additional smaller solar panel that can provide energy to the power unit, thereby enabling the user to run the shower unit on natural renewable sources of energy.

Abstract: A frac dart includes a body having an outer surface and an end including at least one opening. A cutter support is mounted at the end adjacent the at least one opening. A cutter is moveably mounted at the cutter support. A counter support is slideably mounted on the outer surface, and a counter is arranged between the counter support and the cutter support. The cutter is operable to sever a portion of the counter.

Abstract: A portable fresh water source that can dispense water under pressure through a hand-held nozzle for utility and recreational uses, such as for rinsing saltwater from marine equipment, washing hands, showering, cleaning dishes, watering plants, or any other activity in which a portable on-demand fresh water source would be useful. The portable fresh water source includes a reservoir, a battery, a pressurizing pump, and a dispensing apparatus. The battery provides power to the pressurizing pump, which in turn provides water pressure to the dispensing apparatus. A version of the dispensing apparatus is a hose with a nozzle. Another version has a hands-free nozzle to allow a user to control the system without touching the device.