Abstract: The present disclosure provides methods for producing recombinant adeno-associated virus (rAAV) virions. The present disclosure provides compositions for producing rAAV virions.

Abstract: A patient support apparatus includes a support structure having a patient support deck and a side rail coupled to the support structure. The side rail is movable relative to the support structure. A lock releasably locks the side rail in one or more side rail positions, such as in a raised position and an intermediate position. A manual release is coupled to the side rail and operable to unlock the side rail. A bypass lever is provided to allow a user to raise the side rail from a lowered position to the raised position without locking in the intermediate position. A damper is located inside the side rail to counterbalance the weight of the side rail and assist the user in raising the side rail, bi-directionally. The side rail is formed of first and second walls that are heat staked together to form a lightweight side rail of suitable strength.

Abstract: A patient support apparatus includes a support frame and a patient support deck operatively attached to the support frame. The patient support deck includes an adjacent pair of deck sections. An actuator is coupled to a first one of the adjacent deck sections, and the actuator, in combination with a deck articulating assembly, moves the first one of the adjacent deck sections relative to the support frame and second one of the adjacent pair of deck sections between an initial configuration and a raised configuration. In the raised configuration, the inner adjacent end of the first deck section is spaced further from the corresponding inner adjacent end of the second deck section, and the outer end opposite the inner adjacent end of the first one of the adjacent deck sections is spaced further away from the support frame, than in the initial configuration.

Abstract: Provided herein is a method of reducing or preventing sunburn caused from visible and ultraviolet radiation in a subject, the method comprising topically applying to the subject a sunscreen composition comprising inorganic UV filtering agents, antioxidants, and at least one inorganic pigment, wherein the at least one inorganic pigments and antioxidants are present in an amount effective to reduce or prevent sunburn caused from visible light. Also provided herein are sunscreen compositions and methods of increasing the SPF of a sunscreen composition that comprises at least one inorganic UV filtering agent.

Abstract: A modular axle clamp and riser system for use in a suspension system, which includes a top mount having a substantially flat upper surface, a top mount body which extends transversely to the flat upper surface, a pair of opposing ears which extend from the top mount body, and at least one top mount tooth extending from the top mount body in a direction opposite the ears. Also included is a wedge with at least one wedge tooth which matingly engages the at least one top mount tooth, a wedge upper surface, and a pinion angle surface. Further, the wedge defines a pinion angle between the wedge upper surface and the pinion angle surface. Moreover, an axle mount with at least one axle mount tooth which matingly engages at least one of the at least one top mount tooth and the at least one wedge tooth is provided.

Abstract: A turbine engine and method of operating includes an engine core with a compressor, a combustor, and a turbine in axial flow arrangement. A flow path extends through the engine core from the compressor to the turbine to define a flow direction for a working airflow through the engine core.

Abstract: A pin terminal assembly includes a pin terminal having a retention section and a cavity adaptor formed of a non-conductive material and engaging the retention section. The cavity adaptor has an outer shape corresponding to a cavity of a housing in which the pin terminal is inserted. The cavity adaptor retains the pin terminal in the cavity.

Abstract: Steam cracking of ethane, a non-catalytic thermochemical process, remains the dominant means of ethylene production. The severe reaction conditions and energy expenditure involved in this process incentivize the search for alternative reaction pathways and reactor designs which maximize ethylene yield while minimizing cost and energy input. According to the present invention, ethylene yields as high as 68% were obtained with a quartz open tube reactor without the use of a catalyst or a cofed stream of oxidizing agents. The open tube reactor design promotes simplicity, low cost, and negligible coke formation. Reactor designs can be optimized to improve the conversion of ethane to ethylene via non-oxidative dehydrogenation, an approach which shows promise for decentralized production of ethylene from natural gas deposits.

Abstract: A patient support apparatus that comprises a frame and a side rail mounted to the frame. The side rail comprises a side rail body and a pair of arms mounting the side rail body for rotational movement relative to the frame. The pair of arms has a pair of upper pivot connections connected to the side rail body and a pair of lower pivot connections for mounting to the frame. The upper pivot connections engage a timing link.

Abstract: This disclosure relates to methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen such as HER2. Provided are uses of the multi-specific binding protein in combination with a corticosteroid to reduce the risk of infusion-related reactions. Also provided are uses of the multi-specific binding protein in treating cancer that has low or moderate HER2 expression level. The present disclosure also relates to pharmaceutical formulations comprising the multi-specific binding proteins.

Abstract: The invention provides antibodies that specifically bind to Plasminogen Activator inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.

Abstract: Described herein are compounds of Formula I: and their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for example, cachexia, anorexia, or anorexia nervosa; and intermediates and processes for preparing such compounds and salts.

Abstract: A system comprising one or more processors and one or more non-transitory computer-readable media storing computing instructions configured to run on the one or more processors and perform: estimating, using a machine learning model, a respective budget for expenditures based on respective parameters of each of one or more project initiatives associated with physical stores; determining, using a mixed integer linear programming formulation, a time window to execute the each of the one or more project initiatives; generating one or more respective recommendations for the each of the one or more project initiatives for a predetermined time period; and sending instructions to display the one or more respective recommendations on a graphical user interface, wherein the graphical user interface displays a respective status of each of the one or more respective recommendations. Other embodiments are disclosed.

Abstract: A patient support apparatus includes a support frame and a patient support deck operatively attached to the support frame. The patient support deck includes an adjacent pair of deck sections. An actuator is coupled to a first one of the adjacent deck sections, and the actuator, in combination with a deck articulating assembly, moves the first one of the adjacent deck sections relative to the support frame and second one of the adjacent pair of deck sections between an initial configuration and a raised configuration. In the raised configuration, the inner adjacent end of the first deck section is spaced further from the corresponding inner adjacent end of the second deck section, and the outer end opposite the inner adjacent end of the first one of the adjacent deck sections is spaced further away from the support frame, than in the initial configuration.

Abstract: A system and a method are disclosed for enabling assignment of a responder unit to a user on a water vessel. The rescue system transmits a Short Message Service (SMS) message to a user device on the water vessel, the SMS message comprising a selectable option that, when selected, causes a location of the user device to be shared. Based on a selection by a user of the user device of the selectable option, the system receives a plurality of location coordinates from the user device at a plurality of respective times, each respective location coordinate describing a respective location of the user device at its respective time. The system selects a responder unit to assign to the user based on the plurality of location coordinates and a location of each of a plurality of candidate responder units. The system transmits location information to a responder device of the selected responder unit, the location information based on the plurality of location coordinates.

Abstract: The present invention is related to a laundry basket that can be extendable and attachable. Regular laundry baskets only hold a certain amount of clothes once it reaches a certain capacity, but do not allow you to make extra space. Regular laundry baskets are placed near a washer or dryer but do not attach on to machines creating an easy load and unload. Presently, there is no solution for creating more space for overloaded clothes and no solution to creating an easy load and unload into a washing machine or dryer. The present invention provides an extendable attachable laundry basket that includes multiple receptacles that can be slidably extended to provide additional space for clothes and attachable means that creates a firm lock onto a washer or dryer bringing the basket closer to the machine to load or unload the clothes.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes first and second gas permeable panes defining an evacuated gap in communication with a vacuum source; a first exterior pane spaced from the first gas permeable pane defining a first pressurized gap in communication with a source of pressurized gas; and a second exterior pane spaced from the second gas permeable pane defining a second pressurized gap in communication with the source of pressurized gas.

Abstract: An apparatus for storing collectibles is disclosed. The apparatus is particularly useful for storing collectible packs of cards that are commonly sold as “booster packs” for larger decks. The apparatus has multiple rails which support the booster pack without crimping or damaging the flaps at the top and bottom of the pack. As the pack is supported by the flaps and not by friction of the body of the pack itself, the apparatus can have a larger internal space to accommodate a variety of sizes of packs having similar flaps.

Abstract: This application discloses techniques for generating and querying projective hash maps. More specifically, projective hash maps can be used for spatial hashing of data related to N-dimensional points. Each point is projected onto a projection surface to convert the three-dimensional (3D) coordinates for the point to two-dimensional (2D) coordinates associated with the projection surface. Hash values based on the 2D coordinates are then used as an index to store data in the projective hash map. Utilizing the 2D coordinates rather than the 3D coordinates allows for more efficient searches to be performed to locate points in the 3D space. In particular, projective hash maps can be utilized by graphics applications for generating images, and the improved efficiency can, for example, enable a game streaming application on a server to render images transmitted to a user device via a network at faster frame rates.

Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: X1, X2, R1, R2, m and n are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, Parkinson's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.