Patents by Inventor Chung-Fan Chiou
Chung-Fan Chiou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11916022Abstract: Various embodiments of the present disclosure are directed towards a semiconductor processing system including an overlay (OVL) shift measurement device. The OVL shift measurement device is configured to determine an OVL shift between a first wafer and a second wafer, where the second wafer overlies the first wafer. A photolithography device is configured to perform one or more photolithography processes on the second wafer. A controller is configured to perform an alignment process on the photolithography device according to the determined OVL shift. The photolithography device performs the one or more photolithography processes based on the OVL shift.Type: GrantFiled: June 7, 2022Date of Patent: February 27, 2024Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Yeong-Jyh Lin, Ching I Li, De-Yang Chiou, Sz-Fan Chen, Han-Jui Hu, Ching-Hung Wang, Ru-Liang Lee, Chung-Yi Yu
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Patent number: 11674173Abstract: An operation method of a multiplex slide plate device is provided. First, the multiplex slide plate device is assembled, including a slide plate, a sacrificial layer and a housing. The slide plate has reaction vessels, and the sacrificial layer has a microfluidic channel composed of an injection channel, a main channel and a distal channel. A sample solution is injected to the injection channel, such that the sample solution flows from the injection channel through the main channel to the distal channel, wherein the sample solution loads into the reaction vessels. Afterwards, an oil is injected to the injection channel, such that the oil flows from the injection channel through the main channel to the distal channel, wherein the oil removes the sample solution not loaded into the reaction vessels. Next, the sacrificial layer is heated to melt, and the melted sacrificial layer is mixed with the oil.Type: GrantFiled: March 26, 2021Date of Patent: June 13, 2023Assignee: Quark Biosciences Taiwan, Inc.Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Ming-Chuan Hsu
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Patent number: 11676682Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: GrantFiled: November 1, 2019Date of Patent: June 13, 2023Assignee: Industrial Technology Research InstituteInventors: Chao-Chi Pan, Jenn-Yeh Fann, Chung-Fan Chiou, Hung-Chi Chien, Hui-Ling Chen
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Publication number: 20210214772Abstract: An operation method of a multiplex slide plate device is provided. First, the multiplex slide plate device is assembled, including a slide plate, a sacrificial layer and a housing. The slide plate has reaction vessels, and the sacrificial layer has a microfluidic channel composed of an injection channel, a main channel and a distal channel. A sample solution is injected to the injection channel, such that the sample solution flows from the injection channel through the main channel to the distal channel, wherein the sample solution loads into the reaction vessels. Afterwards, an oil is injected to the injection channel, such that the oil flows from the injection channel through the main channel to the distal channel, wherein the oil removes the sample solution not loaded into the reaction vessels. Next, the sacrificial layer is heated to melt, and the melted sacrificial layer is mixed with the oil.Type: ApplicationFiled: March 26, 2021Publication date: July 15, 2021Applicant: Quark Biosciences Taiwan, Inc.Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Ming-Chuan Hsu
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Publication number: 20210187503Abstract: The application discloses an apparatus for single molecule nucleic acids sequencing. The apparatus includes a detection module configured to detect fluorescent light generated from a sequencing chip. The detection module includes a sensor device, an objective lens having a first magnification, and a projective lens having a second magnification. The objective lens and the projective lens are configured to transmit the fluorescent light from the sequencing chip to the sensor device. The second magnification is less than unity.Type: ApplicationFiled: December 16, 2020Publication date: June 24, 2021Inventors: Chung-Fan CHIOU, Kuang-Po CHANG, Chi-Fu YEN, Sheng-Fu LIN
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Patent number: 11008610Abstract: A multiplex slide plate device and an operation method thereof are provided. The multiplex slide plate device includes a slide plate and a sacrificial layer. The slide plate has reaction vessels arranged in an array, an injection hole and an exhaust hole, wherein each of the reaction vessels has an opening portion and a bottom portion. The sacrificial layer has a microfluidic channel, wherein the microfluidic channel has an injection channel, a main channel and a distal channel connected to each other. The sacrificial layer is assembled to the slide plate, wherein the main channel faces the opening portion. A sample solution is injected into the injection channel, such that the sample solution flows from the injection channel through the main channel to the distal channel, wherein the sample solution loads into each of the reaction vessels while flowing through the main channel.Type: GrantFiled: November 15, 2018Date of Patent: May 18, 2021Assignee: Quark Biosciences Taiwan, Inc.Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Ming-Chuan Hsu
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Patent number: 11001885Abstract: An apparatus suitable for single molecule sequencing. The apparatus includes at least one nanowell, a plurality of nucleic acid immobilization moieties, and a plurality of types of nucleic acid fragments. The nanowell has an observation zone. The nucleic acid immobilization moieties are disposed in or proximate to the observation zone. The nucleic acid fragments are immobilized to the nucleic acid immobilization moieties, respectively. At least one polymerase is disposed in the observation zone. A method of sequencing nucleic acid molecules using the above-mentioned apparatus is provided.Type: GrantFiled: June 12, 2018Date of Patent: May 11, 2021Assignee: Personal Genomics Taiwan, Inc.Inventors: Chung-Fan Chiou, Chao-Chi Pan, Ching-Wei Tsai, Bor-Huah Chen, Jian-Hao Ciou
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Patent number: 10996166Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light detector comprising at least two optical sensors capable of determining the intensity of the light; and a computer processing output signal generated by the optical sensors and comparing a result of the processing with a known result corresponding to a known type to determine whether the object belongs to the known type.Type: GrantFiled: August 25, 2017Date of Patent: May 4, 2021Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Hung-Chun Chen, Ming-Chia Li, Chang-Sheng Chu, Yu-Tang Li, Chung-Fan Chiou
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Patent number: 10829802Abstract: A measuring method for amplicon length is provided. A qPCR master mix, a forward primer, a reverse primer, a hybridization probe, a double-stranded DNA binding dye, and nucleic acid samples are added into reaction wells for qPCR reaction, and the fluorescence intensity of each of a hybridization probe and a double-stranded DNA binding dye varying with cycle number is respectively measured. Afterwards, amplicon length is obtained by applying a calculating method.Type: GrantFiled: November 11, 2015Date of Patent: November 10, 2020Assignee: Quark Biosciences Taiwan, Inc.Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Chang-Wei Huang
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Patent number: 10515714Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: GrantFiled: July 25, 2017Date of Patent: December 24, 2019Assignee: Industrial Technology Research InstituteInventors: Chao-Chi Pan, Jenn-Yeh Fann, Chung-Fan Chiou, Hung-Chi Chien, Hui-Ling Chen
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Patent number: 10415084Abstract: A multiplex slide plate device and an operation method thereof are provided. The multiplex slide plate device includes a slide plate and a sacrificial layer. The slide plate has reaction vessels arranged in an array, wherein each of the reaction vessels has an opening portion and a bottom portion. The sacrificial layer has a microfluidic channel, wherein the microfluidic channel has an injection channel, a main channel and a distal channel connected to each other. The sacrificial layer is assembled to the slide plate, wherein the main channel faces the opening portion. A sample solution is injected into the injection channel, such that the sample solution flows from the injection channel through the main channel to the distal channel, wherein the sample solution loads into each of the reaction vessels while flowing through the main channel.Type: GrantFiled: May 9, 2016Date of Patent: September 17, 2019Assignee: Quark Biosciences Taiwan, Inc.Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Ming-Chuan Hsu
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Publication number: 20190256896Abstract: A measuring method for low concentration nucleic acid sample is provided. The measuring method is a nucleic acid measuring method for samples of low nucleic acid concentration range in a qPCR experiment, so as to extend the linear dynamic range of experimental detection and increase detecting sensitivity by correcting the original Cq value. The method includes providing a test plate with a plurality of reaction wells or holes, so as to perform qPCR reaction on the nucleic acid samples. Next, performing the adjustment step based on the positive well measurement value derived from the number of positive wells, so as to correct the Cq value of qPCR reaction to the expected value of linear range.Type: ApplicationFiled: May 10, 2018Publication date: August 22, 2019Applicant: Quark Biosciences, Inc.Inventors: Cheng-Wey Wei, Chang-Wei Huang, Chung-Fan Chiou
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Publication number: 20190112642Abstract: A measuring method for amplicon length is provided. A qPCR master mix, a forward primer, a reverse primer, a hybridization probe, a double-stranded DNA binding dye, and nucleic acid samples are added into reaction wells for qPCR reaction, and the fluorescence intensity of each of a hybridization probe and a double-stranded DNA binding dye varying with cycle number is respectively measured. Afterwards, amplicon length is obtained by applying a calculating method.Type: ApplicationFiled: December 12, 2018Publication date: April 18, 2019Applicant: Quark Biosciences, Inc.Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Chang-Wei Huang
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Publication number: 20190078140Abstract: A multiplex slide plate device and an operation method thereof are provided. The multiplex slide plate device includes a slide plate and a sacrificial layer. The slide plate has reaction vessels arranged in an array, an injection hole and an exhaust hole, wherein each of the reaction vessels has an opening portion and a bottom portion. The sacrificial layer has a microfluidic channel, wherein the microfluidic channel has an injection channel, a main channel and a distal channel connected to each other. The sacrificial layer is assembled to the slide plate, wherein the main channel faces the opening portion. A sample solution is injected into the injection channel, such that the sample solution flows from the injection channel through the main channel to the distal channel, wherein the sample solution loads into each of the reaction vessels while flowing through the main channel.Type: ApplicationFiled: November 15, 2018Publication date: March 14, 2019Applicant: Quark Biosciences, Inc.Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Ming-Chuan Hsu
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Publication number: 20180355422Abstract: An apparatus suitable for single molecule sequencing. The apparatus includes at least one nanowell, a plurality of nucleic acid immobilization moieties, and a plurality of types of nucleic acid fragments. The nanowell has an observation zone. The nucleic acid immobilization moieties are disposed in or proximate to the observation zone. The nucleic acid fragments are immobilized to the nucleic acid immobilization moieties, respectively. At least one polymerase is disposed in the observation zone. A method of sequencing nucleic acid molecules using the above-mentioned apparatus is provided.Type: ApplicationFiled: June 12, 2018Publication date: December 13, 2018Applicant: Personal Genomics Taiwan, Inc.Inventors: Chung-Fan Chiou, Chao-Chi Pan, Ching-Wei Tsai, Bor-Huah Chen, Jian-Hao Ciou
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Patent number: 10112969Abstract: Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.Type: GrantFiled: May 8, 2017Date of Patent: October 30, 2018Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chung-Fan Chiou, Chao-Chi Pan, Jenn-Yeh Fann, Shang-Chia Chang, Tsu-Ju Fu
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Patent number: 9995683Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: GrantFiled: June 18, 2014Date of Patent: June 12, 2018Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
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Publication number: 20180111959Abstract: Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.Type: ApplicationFiled: May 8, 2017Publication date: April 26, 2018Applicant: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Chao-Chi Pan, Jenn-Yeh Fann, Shang-Chia Chang, Tsu-Ju Fu
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Publication number: 20180067050Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light detector comprising at least two optical sensors capable of determining the intensity of the light; and a computer processing output signal generated by the optical sensors and comparing a result of the processing with a known result corresponding to a known type to determine whether the object belongs to the known type.Type: ApplicationFiled: August 25, 2017Publication date: March 8, 2018Inventors: Hung-Chun CHEN, Ming-Chia LI, Chang-Sheng CHU, Yu-Tang LI, Chung-Fan CHIOU
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Publication number: 20180018425Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: ApplicationFiled: July 25, 2017Publication date: January 18, 2018Applicant: Industrial Technology Research InstituteInventors: Chao-Chi PAN, Jenn-Yeh FANN, Chung-Fan CHIOU, Hung-Chi CHIEN, Hui-Ling CHEN