Patents by Inventor Chung-Fan Chiou
Chung-Fan Chiou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8673559Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: GrantFiled: June 8, 2012Date of Patent: March 18, 2014Assignee: Industrial Technology Research InstituteInventors: Chao-Chi Pan, Jenn-Yeh Fann, Chung-Fan Chiou, Hung-Chi Chien, Hui-Ling Chen
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Publication number: 20130230909Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: ApplicationFiled: May 7, 2013Publication date: September 5, 2013Applicant: Industrial Technology Research InstituteInventors: Chao-Chi Pan, Jenn-Yeh Fann, Chung-Fan Chiou, Hung-Chi Chien, Hui-Ling Chen
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Patent number: 8486630Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: GrantFiled: November 5, 2009Date of Patent: July 16, 2013Assignee: Industrial Technology Research InstituteInventors: Chao-Chi Pan, Jenn-Yeh Fann, Chung-Fan Chiou, Hung-Chi Chien, Hui-Ling Chen
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Publication number: 20120295260Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: ApplicationFiled: June 8, 2012Publication date: November 22, 2012Inventors: Chao-Chi Pan, Jenn-Yeh Fann, Chung-Fan Chiou, Hung-Chi Chien, Hui-Ling Chen
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Patent number: 8223043Abstract: The invention provides a data compression method, comprising: (a) obtaining a first reading sequence and a second reading sequence from an identical source by a receiving unit; (b) comparing the first reading sequence with the second reading sequence according to a comparison condition to generate a sequence comparison result by the processor; (c) outputting a final template sequence according to the sequence comparison result by the processor; (d) comparing the final template sequence to each of the first and second reading sequences, to generate a respective difference between the final template sequence and each of the first and second reading sequences by the processor; and (e) compressing the first and second reading sequences according to the final template sequences and all generated differences between the final template sequence and the first and second reading sequences, to generate a compression file by the processor.Type: GrantFiled: December 23, 2010Date of Patent: July 17, 2012Assignee: Industrial Technology Research InstituteInventors: Bai-Kuang Hwang, Jenn-Yeh Fann, Chung-Fan Chiou
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Publication number: 20120077274Abstract: A chemical or biochemical analysis apparatus includes: a computer processor; at least one controller electrically coupled to the computer processor; at least one first base configured with a plurality of dispensing tube assemblies arranged in alignment and electrically coupled to the at least one controller, independently; at least one second base configured with a plurality of the detectors arranged in alignment and electrically coupled to the at least one controller; and a stage, for carrying the at least one multi-well strip having a plurality of wells arranged in alignment and for transporting the multi-well strip to pass through and underneath the plurality of dispensing tube assemblies and the plurality of the detectors arranged in order, electrically coupled to the at least one controller.Type: ApplicationFiled: December 30, 2010Publication date: March 29, 2012Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chung-Fan Chiou, Jyh-Chern Chen, Ming-Te Lin, Chao-Chi Pan, Chein-Shiu Kuo, Jenn-Yeh Fann
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Publication number: 20110306039Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: ApplicationFiled: June 11, 2010Publication date: December 15, 2011Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
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Publication number: 20110306143Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: ApplicationFiled: July 29, 2010Publication date: December 15, 2011Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
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Publication number: 20110300534Abstract: Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.Type: ApplicationFiled: May 27, 2011Publication date: December 8, 2011Applicant: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Chao-Chi Pan, Jenn-Yeh Fann, Shang-Chia Chang, Tsu-Ju Fu
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Publication number: 20110223590Abstract: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.Type: ApplicationFiled: March 11, 2011Publication date: September 15, 2011Applicant: Industrial Technology Research InstituteInventors: Chung-Fan CHIOU, Ying-Chih Pu, Chao-Chi Pan, Chih-Tsung Shih, Ming-Chia Li, Chein-Shiu Kuo, Hung-Chi Chien, Chang-Sheng Chu
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Publication number: 20110163898Abstract: The invention provides a data compression method, comprising: (a) obtaining a first reading sequence and a second reading sequence from an identical source by a receiving unit; (b) comparing the first reading sequence with the second reading sequence according to a comparison condition to generate a sequence comparison result by the processor; (c) outputting a final template sequence according to the sequence comparison result by the processor; (d) comparing the final template sequence to each of the first and second reading sequences, to generate a respective difference between the final template sequence and each of the first and second reading sequences by the processor; and (e) compressing the first and second reading sequences according to the final template sequences and all generated differences between the final template sequence and the first and second reading sequences, to generate a compression file by the processor.Type: ApplicationFiled: December 23, 2010Publication date: July 7, 2011Inventors: Bai-Kuang HWANG, Jenn-Yeh FANN, Chung-Fan CHIOU
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Patent number: 7811810Abstract: A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule.Type: GrantFiled: July 9, 2009Date of Patent: October 12, 2010Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Cheng-Wei Chu, Yu-Tang Li, Chang-Sheng Chu, Shuang-Chao Chung, Chih-Hsun Fan
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Publication number: 20100256918Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light detector comprising at least two optical sensors capable of determining the intensity of the light; and a computer processing output signal generated by the optical sensors and comparing a result of the processing with a known result corresponding to a known type to determine whether the object belongs to the known type.Type: ApplicationFiled: March 9, 2010Publication date: October 7, 2010Inventors: Hung-Chun Chen, Ming-Chia Li, Chang-Sheng Chu, Yu-Tang Li, Chung-Fan Chiou
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Patent number: 7767441Abstract: A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule.Type: GrantFiled: October 21, 2008Date of Patent: August 3, 2010Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Cheng-Wei Chu, Shang-Chia Chang, Yu-Tang Li, Chao-Chi Pan, Bin-Cheng Yao
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Publication number: 20100121582Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: ApplicationFiled: November 5, 2009Publication date: May 13, 2010Inventors: Chao-Chi PAN, Jenn-Yeh Fann, Chung-Fan Chiou, Hung-Chi Chien, Hui-Ling Chen
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Publication number: 20090311774Abstract: A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule.Type: ApplicationFiled: July 9, 2009Publication date: December 17, 2009Inventors: CHUNG-FAN CHIOU, Cheng-Wei Chu, Yu-Tang Li, Chang-Sheng Chu, Shuang-Chao Chung, Chih-Hsun Fan
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Publication number: 20090146076Abstract: A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule.Type: ApplicationFiled: October 21, 2008Publication date: June 11, 2009Inventors: Chung-Fan CHIOU, Cheng-Wei CHU, Shang-Chia CHANG, Yu-Tang LI, Chao-Chi PAN, Bin-Cheng YAO
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Patent number: 7163284Abstract: An inkjet cartridge for dispensing a predetermined amount of reagents is provided. The inkjet cartridge comprises an inkjet print head and an array of capillary tubes. The print head is provided with a plurality of channels. The capillary tubes, filled with predetermined reagents, are disposed on the inkjet print head so as to communicate with the channels respectively and provide capillarity sufficient to prevent the reagents in the capillary tubes from leaking through the channels but not so great as to prevent the reagents in the capillary tubes from dispensing through the channels.Type: GrantFiled: December 12, 2001Date of Patent: January 16, 2007Assignee: Industrial Technology Research InstituteInventors: Shyh-Haur Su, Ching-Yi Mao, Je-Ping Hu, Chung-Fan Chiou
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Patent number: 6991311Abstract: An apparatus and method for introducing micro-volume liquid. The method includes the following steps. A multi-channel inkjet print head is provided. The multi-channel inkjet print head includes a nozzle plate and a cartridge. The nozzle plate includes a plurality of nozzles. The cartridge includes a plurality of channels, communicating with the nozzles on the nozzle plate, and a plurality of openings located at the channels. The nozzle plate contacts with a buffer. The buffer is introduced into the channels via the nozzles on the nozzle plate by pressure. Reagents are introduced into the channels through the openings.Type: GrantFiled: December 12, 2003Date of Patent: January 31, 2006Assignees: Industrial Technology Research Institute, Phalanx Biotech Group, Inc.Inventors: Shyh-Haur Su, Yung-Chin Lee, Wu-Li Chen, Chung-Fan Chiou, Chien-Tsung Wu, Wen-Yeh Liao, Chiu-Neng Chen
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Patent number: 6974529Abstract: A hand-held electrophoresis detection device and support thereof. The hand-held electrophoresis detection device includes a support and a cartridge. The cartridge attaches a sample, and is disposed in the support in a detachable manner.Type: GrantFiled: December 11, 2002Date of Patent: December 13, 2005Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Chih-Wei Ho, Bor-Iuan Jan, Jian Je Jian, Chien-Tsung Wu, Hsi-Hsin Shih