Patents by Inventor Craig E. Masse

Craig E. Masse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of deuterated morpholine derivatives
    Patent number: 9453009
    Abstract: The present invention is directed to a process for preparing a 2,26,6-d4-morpholine derivative represented by Structural Formula (I): or a salt thereof.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: September 27, 2016
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Julie F. Liu, Xuejun Tang, Scott L. Harbeson, Craig E. Masse
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20160251376
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 1, 2016
    Inventors: Markus Dahlgren, Jeremy Robert Greenwood, Geraldine C. Harriman, Joshua Jahmil Kennedy-Smith, Craig E. Masse, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160193216
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 20, 2015
    Publication date: July 7, 2016
    Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Shaughnessy Robinson, Mee Shelley, Matthew David Wessel, Jeremy Robert Greenwood, Craig E. Masse, Rosana Kapeller-Libermann
  • ACC INHIBITORS AND USES THEREOF
    Publication number: 20160185799
    Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 8, 2014
    Publication date: June 30, 2016
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, George Borg, Craig E. Masse
  • ACC INHIBITORS AND USES THEREOF
    Publication number: 20160185783
    Abstract: The present invention provides for compounds of formula I as acetyl-CoA carboxylase (ACC) inhibitors. The ACC inhibitors are useful for the prevention or treatment of metabolic syndrome, including obesity, dyslipidemia and hyperlipidemia in humans. The inhibitor compounds are also capable of inhibiting the ACC enzyme found in plants, parasites and bacteria.
    Type: Application
    Filed: May 8, 2014
    Publication date: June 30, 2016
    Inventors: Jeremy Robert GREENWOOD, Geraldine C. HARRIMAN, George BORG, Craig E. MASSE
  • IRAK inhibitors and uses thereof
    Patent number: 9340554
    Abstract: The present invention provides 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine compounds and pharmaceutical compositions thereof as inhibitors of IRAK.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: May 17, 2016
    Assignee: NIMBUS IRIS, INC.
    Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse, Mee Shelley
  • TYK2 inhibitors and uses thereof
    Patent number: 9340540
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: May 17, 2016
    Assignee: NIMBUS LAKSHMI, INC.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Donna L. Romero, Geraldine C. Harriman, Ronald T. Wester, Mee Shelley, Joshua Jahmil Kennedy-Smith, Markus Dahlgren
  • ACC INHIBITORS AND USES THEREOF
    Publication number: 20160108061
    Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same. Specifically, bicyclic heteroaryl derivatives containing a imidazole, thiazole or oxazole fused to a pyridinone, pyrimidinone or pyrimidindione are provided. These compounds have therapeutic utility toward treating an ACC enzyme mediated disorder such as obesity in a subject, upon administration in an effective amount to said subject.
    Type: Application
    Filed: May 8, 2014
    Publication date: April 21, 2016
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, George Borg, Craig E. Masse
  • ACC INHIBITORS AND USES THEREOF
    Publication number: 20160108060
    Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 8, 2014
    Publication date: April 21, 2016
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, George Borg, Craig E. Masse
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160068543
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 17, 2015
    Publication date: March 10, 2016
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • Tetrahydronaphthalene derivatives
    Patent number: 9273009
    Abstract: This invention relates to novel tetrahydronaphthalene derivatives, and pharmaceutically acceptable salts thereof according to the following formulae, in one embodiment: as described herein. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a selective T-type calcium channel blocker.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: March 1, 2016
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Roger Tung, Craig E. Masse, Julie F. Liu
  • Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds
    Patent number: 9260432
    Abstract: This invention relates to novel compounds of the Formula A, B, or C, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising one or more compounds of this invention and a carrier.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: February 16, 2016
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Roger D. Tung, Craig E. Masse
  • DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES
    Publication number: 20160031801
    Abstract: This invention relates to novel 2-amino-3-hydroxypropanoic acid derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an NMDA glycine-site antagonist.
    Type: Application
    Filed: August 4, 2015
    Publication date: February 4, 2016
    Applicant: Concert Pharmaceuticals, Inc.
    Inventor: Craig E. Masse
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160002256
    Abstract: The present invention provides thienopyridine compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 17, 2015
    Publication date: January 7, 2016
    Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Craig E. Masse, Shaughnessy Robinson, Jeremy R. Greenwood
  • Derivatives of Pyrazole-Substituted Amino-Heteroaryl Compounds
    Publication number: 20150366853
    Abstract: This invention relates to novel pyrazole-substituted amino-heteroaryl compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of anaplastic lymphoma kinase (ALK).
    Type: Application
    Filed: August 31, 2015
    Publication date: December 24, 2015
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Bhaumik A. Pandya, Craig E. Masse, Ian Robert Silverman, Roger D. Tung
  • IRAK inhibitors and uses thereof
    Patent number: 9212190
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: December 15, 2015
    Assignee: Nimbus Iris, Inc.
    Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Shaughnessy Robinson, Mee Shelley, Matthew David Wessel, Jeremy Robert Greenwood, Craig E. Masse, Rosana Kapeller-Libermann
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20150329498
    Abstract: The present invention provides quinazoline and quinoline compounds, compositions thereof, and methods of using the same. Also disclosed is the activity of such compounds as inhibitors of IRAK enzymes.
    Type: Application
    Filed: April 21, 2015
    Publication date: November 19, 2015
    Inventors: Donna L. Romero, Shaughnessy Robinson, Jeremy Robert Greenwood, Mee Shelley, Craig E. Masse, Geraldine C. Harriman
  • IRAK inhibitors and uses thereof
    Patent number: 9175007
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: November 3, 2015
    Assignee: Nimbus Iris, Inc.
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • Derivatives of pyrazole-substituted amino-heteroaryl compounds
    Patent number: 9145390
    Abstract: This invention relates to novel pyrazole-substituted amino-heteroaryl compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of anaplastic lymphoma kinase (ALK).
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: September 29, 2015
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Bhaumik Pandya, Craig E. Masse, Ian Robert Silverman, Roger Tung
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20150266875
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: February 27, 2015
    Publication date: September 24, 2015
    Inventors: Craig E. MASSE, Jeremy Robert GREENWOOD, Donna L. ROMERO, Geraldine C. HARRIMAN, Ronald T. WESTER, Mee SHELLEY, Joshua Jahmil KENNEDY-SMITH, Markus DAHLGREN