Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, {(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: A carbon article shaped as a brake disc, the brake disc being coated with an anti-oxidant coating obtained by applying as a primer coat a composition including orthophosphoric acid, aluminum hydroxide, demineralized water, and a wetting additive; curing the primer coat; applying as a barrier coat a composition including orthophosphoric acid, aluminum hydroxide, demineralized water, colloidal silica, silicon hexaboride, boron, and a wetting additive; and curing the barrier coat.

Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, {[(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibittors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: A method is provided for estimating range per full charge (RPC) for a vehicle. The method includes a controller which may, in response to detecting presence of a predefined condition impacting vehicle energy consumption, output to an interface by a controller a RPC and indicia indicative of an extent to which the predefined condition is affecting the RPC. An electrified vehicle including one or more vehicle components, a traction battery to supply energy to the vehicle components, one or more sensors, and a controller is also provided. The one or more sensors monitor the vehicle components, traction battery, and preselected ambient conditions. The controller is configured to, in response to input from the sensors, generate output for an interface which includes a RPC and indicia indicative of an extent of impact on the RPC by each of the ambient conditions and operation of the components and battery.

Abstract: Resuscitation devices for performing external chest compression (ECC) and defibrillation on a person and methods using the devices are disclosed. The disclosed devices can include chest compression members and a communication module that can communicate with a remote command center. The disclosed devices can also include an optional defibrillation module that may be integrated. The devices can be coupled to a backboard and can include physiological sensors, electrodes, wheels, controllers, human interface devices, cooling modules, ventilators, cameras, and voice output devices. Methods can include defibrillating, pacing, ventilating, cooling, and performing ECC in an integrated, coordinated, and/or synchronous manner using the full capabilities of the device. Some devices include controllers executing methods for automatically performing the coordinated activities utilizing the device capabilities.

Abstract: Devices, systems, and methods interface a cassette with an eye treatment system console to provide coupling between the console and an eye treatment probe. The console may receive the cassette using a driven axial translation linkage that inhibits rotation of the cassette. The cassette may facilitate accurately positioning of a pressure sensor relative to a the console by allowing sliding movement between the sensor and a cassette body. Multiple peristaltic drives may be mounted to the console so that their rotors rotate about a common axis. An integrated mount structure may support and/or position components of the console which will interface with cassette, and an axially compressible vacuum connector of the console seal to a tapered vacuum coupler of the cassette.

Abstract: A user interface method and apparatus is described for use with a defibrillator (100) such as an automated external defibrillator (AED). The user interface comprises a plurality of layered user interface components which become available to the operator of the defibrillator (100) as they become necessary or appropriate during the operation of the defibrillator (100) and treatment of the patient. In one embodiment, the layered user interface components comprise an on/off actuator (108), a lid (104), an electrode package (120) containing defibrillation electrodes (142, 144), and a shock key (170), as well as accompanying visual and aural instructions for operating the defibrillator (100) and for treating the patient.

Abstract: A computer-implemented technique is described herein for customizing user experience on a per-user basis. In some implementations, the technique involves: collecting feedback information from a user pertaining to the user's interaction with a program feature; determining a modification to be made to the program feature based on the feedback information; making the modification; notifying the user of the modification; and receiving the user's post-modification assessment of the modification. The technique enables a program provider to quickly modify program features in an automated manner, with no (or reduced) effort by human developers, and at consequent reduced cost. In addition, the technique improves the users' experience with the program features since the program modifications are tailored to each user's preferences.

Abstract: Work flows are modeled as a graph of interdependent tasks to be performed. The tasks to be performed are set by a task file module configured to enable interactions between tasks and including modules for event viewing, protocol assistance, smart messaging, smart indices, reference material lookup. A decision support manager module is configured to construct data and model profiles for storage in a data and model profile bank, events for storage in a decision support events bank, and protocols for storage in a decision support protocol bank. Configuration files are provided to specify a configuration for execution of one of the tasks. Data entered through a user interface or from a network via a wireless or wired communication module may define task files in the task files module, configuration files in the configuration files module, as well as data, events, and protocols to be used for a defibrillation procedure.

Abstract: A method and apparatus for identifying information for a product. User input selecting a proxy object in a product design on a computer system is received. The proxy object refers to a number of product standards used in the product design and is associated with a component in the product design. A role of a user is identified. A request for standards information for the component is sent to an interpreter module. The role of the user is included in the request. The standards information is received in a format based on the role of the operator such that the standards information is displayed in the computer system.

Abstract: A hybrid communications assembly for a spacecraft is provided. The hybrid communications assembly may include an assembly base, one or more laser communications terminals mounted on the assembly base, and a radio frequency antenna system mounted on the assembly base. The assembly may be mounted on an earth deck of the spacecraft, and the laser communications terminals may be mounted at an angle between 20 and 70 degrees with respect to the earth deck. A thermal radiator may be mounted on the assembly base and thermally coupled to the laser communications terminal. The radio frequency antenna system may be disposed between the laser communications terminals. The radio frequency antenna system may include one or more antenna reflectors mounted on the assembly base and one or more antenna feeds mounted on a tower.

Abstract: An eye treatment cassette includes a handpiece, a vacuum source, a holding tank, a collection bag, and a displacement-based pump. The handpiece is configured to aspirate fluids from a patient's eye. The vacuum source communicates with the handpiece. The holding tank is interposed between the handpiece and the vacuum source, and is configured to hold the aspirated fluids. The collection bag is connected to the holding tank for collecting the aspirated fluids. The pump is coupled to the holding tank and is configured to operate while the vacuum source continues to aspirate fluids via the handpiece to drain the aspirated fluids from the holding tank.

Abstract: A modular external defibrillator system in embodiments of the teachings may include one or more of the following features: a base containing a defibrillator to deliver a defibrillation shock to a patient, (b) one or more pods each connectable to a patient via patient lead cables to collect at least one patient vital sign, the pods operable at a distance from the base, (c) a wireless communications link between the base and a selected one of the two or more pods to carry patient data from the selected pod to the base, the selection being based on which pod is associated with the base.

Abstract: A vehicle includes an internal combustion engine, a driver interface having a first driver-activated selector, and a controller. The controller selectively operates the engine according to a first mode and a second mode. In the first mode the engine runs continuously. In the second mode the engine is turned off in response to a first set of operating conditions and turned on in response to a second set of operating conditions. The controller further, in response to a driver activation of the first selector, controls the engine according to the first mode and, in response to an anticipated end of a first vehicle acceleration event subsequent the driver activation of the first selector, controls the engine according to the second mode.

Abstract: A modular external defibrillator system in embodiments of the teachings may include one or more of the following features: a base containing a defibrillator to deliver a defibrillation shock to a patient, (b) one or more pods each connectable to a patient via patient lead cables to collect at least one patient vital sign, the pods operable at a distance from the base, (c) a wireless communications link between the base and a selected one of the two or more pods to carry the at least one vital sign from the selected pod to the base, the selection being based on which pod is associated with the base.

Abstract: A method and system of controlling a configuration of a vehicle power-assisted steering (PAS) system is provided. The method includes detecting at a vehicle a change between two-wheel-drive driveline operation and four-wheel-drive driveline operation; accessing a pre-defined PAS profile stored at the vehicle based on the detected change; and operating the vehicle PAS system using at least one variable included in the PAS profile in response to the detected change in driveline operation.

Abstract: A vehicle includes a display and a controller that operates the display. A first icon representing a reference energy consumption value based on a predetermined target energy consumption rate is displayed. A second icon representing a present energy consumption value is displayed. The icons are positioned relative to one another based on a difference between the reference energy consumption value and the present energy consumption value. A numerical scale may be displayed having values associated with the first and second icons. A vehicle having a hybrid powertrain including a traction battery may display an effective electric distance traveled that is based on a ratio of power supplied by the traction battery to total power supplied by the powertrain.

Abstract: Work flows are modeled as a graph of interdependent tasks to be performed. The tasks to be performed are set by a task file module configured to enable interactions between tasks and including modules for event viewing, protocol assistance, smart messaging, smart indices, reference material lookup. A decision support manager module is configured to construct data and model profiles for storage in a data and model profile bank, events for storage in a decision support events bank, and protocols for storage in a decision support protocol bank. Configuration files are provided to specify a configuration for execution of one of the tasks. Data entered through a user interface or from a network via a wireless or wired communication module may define task files in the task files module, configuration files in the configuration files module, as well as data, events, and protocols to be used for a defibrillation procedure.

Abstract: A method is provided for estimating range per full charge (RPC) for a vehicle. The method includes a controller which may, in response to detecting presence of a predefined condition impacting vehicle energy consumption, output to an interface by a controller a RPC and indicia indicative of an extent to which the predefined condition is affecting the RPC. An electrified vehicle including one or more vehicle components, a traction battery to supply energy to the vehicle components, one or more sensors, and a controller is also provided. The one or more sensors monitor the vehicle components, traction battery, and preselected ambient conditions. The controller is configured to, in response to input from the sensors, generate output for an interface which includes a RPC and indicia indicative of an extent of impact on the RPC by each of the ambient conditions and operation of the components and battery.

Abstract: A defibrillator is provided with two processors for enhancing the defibrillation process. A first processor is dedicated to controlling when an electrical charge is applied to a patient. A second processor is dedicated to data operations for enhancing the coaching of the defibrillation process. The second data processor is in communication with one or more external devices for transmission and receipt of network data for further enhancing the coaching process. The second data processor allows both the defibrillator to be maintained with updated network data and software and the one or more external devices to be maintained with updated defibrillator data. Independent controllers provide multiple processing paths on critical charge and coaching functions; with the second data processor further providing redundancy control in the event of any malfunction of the first charge processor.