Abstract: The present invention relates to a conjugate in which an immunoglobulin Fc region is linked to therapeutic enzymes through a non-peptide polymer linkage moiety, and more specifically, to a conjugate in which a non-peptide polymer linkage moiety is specifically linked to an immunoglobulin Fc, a method of preparing the same, and a composition comprising the same.

Abstract: A reconfigurable radio equipment may include at least two radio computers; a communication services layer comprising an administrator, a mobility policy manager, a networking stack, and a monitor; and a routing entity performing communications among the at least two radio computers and the communication services layer.

Abstract: The present invention relates to insulin and/or an insulin analogue conjugate, and a use thereof, wherein the insulin and/or insulin analogue have improved in vivo durability and stability by linking the same with an Fc region of immunoglobulin. The insulin and/or an insulin analogue conjugate of the present invention show an in vivo activity similar to that of insulin. In addition, the insulin and/or insulin analogue conjugate of the present invention are long-acting formulations of insulin and/or the analogue thereof, in which serum half-life is remarkably increased, and therefore, the present invention provides remarkable insulin and/or an insulin analogue conjugate, which do not induce hypoglycemia, a drawback of insulin treatment.

Abstract: The present invention relates to a healthcare data providing method for allowing viewing of personal health data stored in a user application, according to a user's approval, so as to enable a medical staff to check personal health data of the user before or during treatment of the user.

Abstract: The present invention relates to a protein complex, in which a physiologically active polypeptide modified with a fatty acid molecule and an immunoglobulin Fc region are linked through a non-peptide polymer linker, a pharmaceutical composition comprising the same, and a method for preparing the protein complex. The protein complex extends the blood half-life of the physiologically active polypeptide through the linkage of the binding site of immunoglobulin. Fc and the intramolecular bonding of the fatty acid molecule; has an excellent in vivo activity; and has no risk of inducing an immune response.

Abstract: A reconfigurable radio equipment may include at least two radio computers; a communication services layer comprising an administrator, a mobility policy manager, a networking stack, and a monitor; and a routing entity performing communications among the at least two radio computers and the communication services layer.

Abstract: Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs.

Abstract: Provided is a conjugate in which an immunoglobulin Fc region is linked to an iduronate-2-sulfatase enzyme through a non-peptide polymer linker moiety. Further, provided are a conjugate, a method for preparing the same, and a composition including the same in which a non-peptide polymer linker moiety is specifically linked to an immunoglobulin Fc.

Abstract: A display apparatus includes a rear chassis, a light source installed in the rear chassis to emit light, a diffuser plate that diffuses light emitted from the light source, a liquid crystal panel positioned in front of the diffuser plate to display an image, a front chassis that supports the liquid crystal panel, and a middle mold coupled between the front chassis and the rear chassis to support the diffuser plate, and is provided with a curved reflective surface formed in a curved shape to reflect the light, which is emitted from the light source module, to the diffuser plate.

Abstract: Improved processing of sensor data (e.g., LiDAR data) can be used to distinguish between free space and objects/hazards. Autonomous vehicles can use such information for performing autonomous driving and/or parking operations. LiDAR data can include a plurality of range measurements (e.g., forming a 3D point cloud). Each of the range measurements can correspond to a respective LiDAR channel and azimuth angle. The processing of LiDAR data can include identifying one or more of the plurality of range measurements as ground points or non-ground points based on one or more point criteria. The one or more point criteria can include a ground projection criterion and an angular variation criterion.

Abstract: Improved processing of sensor data (e.g., LiDAR data) can be used to distinguish between free space and objects/hazards. Autonomous vehicles can use such information for performing autonomous driving and/or parking operations. LiDAR data can include a plurality of range measurements (e.g., forming a 3D point cloud). Each of the range measurements can correspond to a respective LiDAR channel and azimuth angle. The processing of LiDAR data can include identifying one or more paths as candidate ground paths based on one or more path criteria. The processing of LiDAR data can also include identifying one or more of the plurality of range measurements as ground points or non-ground points based on the one or more paths identified as candidate ground paths and based on one or more point criteria.

Abstract: A method for preparing a conjugate by linking a physiologically active polypeptide, a non-peptidyl polymer linker, and an immunoglobulin constant region via a covalent bond are disclosed. The method enables an efficient preparation of a physiologically active polypeptide conjugate, in which a salt is used in a coupling reaction to improve the problem of low production yield during preparation of the physiologically active polypeptide conjugate.

Abstract: A nonvolatile memory device includes a memory cell array that includes memory blocks, wherein each of the memory blocks includes pages each including memory cells, a row decoder circuit that selects one of the pages from a selected memory block of the memory blocks in a write operation and selects memory cells of a close unit from the selected memory block in a close operation, and a page buffer circuit that writes data into memory cells of a page selected by the row decoder circuit in the write operation and writes dummy data into the memory cells of the close unit selected by the row decoder circuit in the close operation. The close unit includes one or more pages, and, in the close operation, the row decoder circuit adjusts a size of the close unit.

Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: Disclosed are a composition for preventing or treating diabetes, disbesity or diabetic complications, containing an oxyntomodulin analog as an active ingredient and a method for treating diabetes, diabesity or diabetic complications, including administering a pharmaceutically effective amount of an oxyntomodulin analog to a subject. The oxyntomodulin analog shows a greater activity to activate a GLP-1 receptor and a glucagon receptor, than native oxyntomodulin. The oxyntomodulin analog induces an expansion of beta-cells and increases insulin secretion, thereby reducing blood glucose levels that were increased due to a high-calorie and high-fat diet. The oxyntomodulin analog induces decreases in a body weight and appetite to improve insulin sensitivity and is useful in maintaining normal blood glucose levels.

Abstract: Improved processing of sensor data (e.g., LiDAR data) can be used to distinguish between free space and objects/hazards. Autonomous vehicles can use such information for performing autonomous driving and/or parking operations. LiDAR data can include a plurality of range measurements (e.g., forming a 3D point cloud). Each of the range measurements can correspond to a respective LiDAR channel and azimuth angle. The processing of LiDAR data can include identifying one or more paths as candidate ground paths based on one or more path criteria. The processing of LiDAR data can also include identifying one or more of the plurality of range measurements as ground points or non-ground points based on the one or more paths identified as candidate ground paths and based on one or more point criteria.

Abstract: The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.

Abstract: Improved processing of sensor data (e.g., LiDAR data) can be used to distinguish between free space and objects/hazards. Autonomous vehicles can use such information for performing autonomous driving and/or parking operations. LiDAR data can include a plurality of range measurements (e.g., forming a 3D point cloud). Each of the range measurements can correspond to a respective LiDAR channel and azimuth angle. The processing of LiDAR data can include identifying one or more of the plurality of range measurements as ground points or non-ground points based on one or more point criteria. The one or more point criteria can include a ground projection criterion and an angular variation criterion.

Abstract: A system for use in a vehicle, the system comprising one or more sensors; one or more processors coupled to the one or more sensors; and a memory including instructions, which when executed by the one or more processors, cause the one or more processors to perform a method. The method comprising determining an estimated location of the vehicle, obtaining map information based on the estimated location of the vehicle, obtaining sensor information relating the vehicle's proximate surroundings from the one or more sensors, detecting a first landmark and a second landmark in physical proximity to the vehicle based on the sensor information, and localizing the vehicle location based on the map information and the first and second landmarks.

Abstract: Provided are a liquid formulation of long-acting insulinotropic peptide conjugate, containing a pharmaceutically effective amount of long-acting insulinotropic peptide conjugate consisting of a physiologically active peptide, insulinotropic peptide, and an immunoglobulin Fc region; and an albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, and a non-ionic surfactant, and a method for preparing the formulation. For the purpose of preventing microbial contamination, a preservative may be added. The liquid formulation of the present invention is free of human serum albumin and other potentially hazardous factors to body, having no risk of viral contamination, and thus can provide excellent storage stability for insulinotropic peptide conjugates at high concentration.