Abstract: An acoustic transmitter with preferably a plurality of piezoelectric plates configured to optimized acoustic pressure output within a desired frequency range while meeting physical restrictions of LWD and MWD logging systems. The transmitter is disposed in a recess in the perimeter of a logging tool housing to reduce acoustic pressure waves transmitted directly along the tool housing and to optimize acoustic energy transmission into the borehole environs. In order to increase acoustic pressure output at a desired logging frequency range, the plurality of piezoelectric plates are connected electrically in parallel and fired simultaneously. The polarity of the plates and the wiring arrangement are such that each plate expands or contracts in a common direction during simultaneous firing by an applied voltage. The desired output frequency is obtained by selectively polarizing and dimensioning the plates within the plate assembly.

Abstract: The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

Abstract: A geometrically optimized expansion cone for radially expanding a tubular member. In some embodiments, the expansion cone includes an annular body having an outer surface. The outer surface includes a linear surface having a constant diameter, a curvilinear surface extending from the linear surface, a recessed surface having a diameter less than the diameter of the curvilinear surface, and a chamfer between the recessed surface and the curvilinear surface. The diameter of the linear surface is substantially equal to an inner diameter of the tubular member after expansion, while the chamfer has a maximum diameter less than an inner diameter of the tubular member prior to expansion. The curvilinear surface has a diameter defined by a radius of curvature which is tangent to the chamfer at the maximum diameter and tangent to the linear surface.

Abstract: The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

Abstract: The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

Abstract: A street sign method, system and apparatus includes at least one translucent sign face, a solar photovoltaic panel system for generating electrical energy from sunlight, a rechargeable battery system for storing the electrical energy during the day, at least one Light Emitting Diode (LED) powered by the electrical energy stored in the rechargeable battery system, and a control circuit powered by the rechargeable battery system and configured to operate the at least one LED to illuminate the at least one sign face. The control circuit is configured to calculate an amount of electrical power that can be supplied from the rechargeable battery system to the at least one LED so that said the at least one LED operates at a relatively constant level of LED light output brightness during substantially the entire night time hours based on solar energy supplied to the rechargeable battery system during the previous daytime hours. The street name sign is mountable to a post or pole.

Abstract: In various embodiments, the system includes a tubular female end portion of the first pole section and a male end portion of the second pole section that is insertable into the female end portion. Additionally, the system includes a locking nut including a body portion and a neck portion and is threadingly engaged with the male end portion. Furthermore, the system includes a biased locking sleeve assembly that includes a locking sleeve having an internal cavity such that the locking sleeve fits over the locking nut neck portion, and a biasing device located within the interior cavity of the locking sleeve for applying opposing forces to the locking nut and the locking sleeve.

Abstract: A system and a method for securely connecting, or interlocking two pole sections together to ensure that they do not disconnect during use. The system includes a tubular female end portion of the first pole section and a male end portion of the second pole section that is insertable into the female end portion. The system additionally includes a locking nut threadingly engaged with the male end portion that is rotatable on the male end portion to longitudinally transition the locking nut into contact with the female end portion to fixedly interlock the male and female end portions. Furthermore, the system includes a biased locking sleeve assembly slidably and rotatably mounted on a locking assembly portion of the second pole. The locking sleeve assembly can include a locking sleeve and a biased plunger slidingly positioned within an interior of the locking sleeve for applying a locking force to the locking nut.

Abstract: A monopole acoustic transmitter for logging-while-drilling comprising as a ring that comprises one or more piezoelectric arc segments. The ring is oriented in a plane whose normal is essentially coincident with the major axis of a logging tool in which it is disposed. The ring disposed within a recess on the outer surface of a short, cylindrical insert. The insert is inserted into a drill collar, rather than into the wall of the collar. The ring can comprise a continuous ring of piezoelectric material, or alternately arc segments or active ring segments of piezoelectric ceramic bonded to segments of other materials such as alumina to increase the frequency or heavy metals such as tungsten to reduce the frequency. The material and dimensions of the material used in-between the piezoelectric segments is chosen to alter the frequency of the ring.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

Abstract: The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

Abstract: A monopole acoustic transmitter with at least one disc assembly with a plurality of piezoelectric discs configured to optimized acoustic pressure output within a desired frequency range while meeting physical restrictions of LWD and MWD logging systems. The transmitter is disposed in a recess or “slot” in the perimeter of a logging tool housing to reduce acoustic pressure waves transmitted directly along the tool housing and to optimize acoustic energy transmission into the borehole environs. In order to increase acoustic pressure output at a desired logging frequency range, the plurality of piezoelectric discs in each of at least one disc assembly are connected electrically in parallel and fired simultaneously. The polarity of the discs and the wiring arrangement are such that each disc expands or contracts in a common direction during simultaneous firing by an applied voltage.

Abstract: A manipulator for remotely controlled underwater operation in a nuclear radiation environment to perform service activities at difficult to access regions of the reactor vessel is disclosed. The manipulator includes six degrees of freedom in its ability to move so that it can get past obstructions inside a reactor vessel to access and service remote locations in the vessel. The manipulator also includes a rotary drive for inserting and removing the manipulator into and from a reactor vessel and for rotating the manipulator within the vessel. It also includes an arm with two rotary joints and three pivot joints that can be deployed for better access to difficult to reach locations. The manipulator, which is remotely operated, can be used to manipulate a variety of tools to perform various service activities. The tools, which are attached to the end of the arm, include a water jet, a gripper, a cutter and a camera.

Abstract: An assembly adapted to access a weld extending circumferentially around a core shroud of a nuclear reactor, wherein the core shroud is contained in a pressure vessel reactor, the assembly including: a baffle plate rail having a lower surface adapted to abut a baffle plate in a gap between the core shroud and the pressure vessel reactor; a telescoping rail slidably coupled to an upper region of the baffle plate rail, and a reciprocating rail slidably coupled to an upper region of the telescoping rail, wherein the reciprocating rail includes at least one of a weld conditioning tool, a weld inspection sensor and a weld repair device.

Abstract: The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

Abstract: A geometrically optimized expansion cone for radially expanding a tubular member. In some embodiments, the expansion cone includes an annular body having an outer surface. The outer surface includes a linear surface having a constant diameter, a curvilinear surface extending from the linear surface, a recessed surface having a diameter less than the diameter of the curvilinear surface, and a chamfer between the recessed surface and the curvilinear surface. The diameter of the linear surface is substantially equal to an inner diameter of the tubular member after expansion, while the chamfer has a maximum diameter less than an inner diameter of the tubular member prior to expansion. The curvilinear surface has a diameter defined by a radius of curvature which is tangent to the chamfer at the maximum diameter and tangent to the linear surface.

Abstract: A monopole acoustic transmitter for logging-while-drilling comprising as a ring that comprises one or more piezoelectric arc segments. The ring is oriented in a plane whose normal is essentially coincident with the major axis of a logging tool in which it is disposed. The ring disposed within a recess on the outer surface of a short, cylindrical insert. The insert is inserted into a drill collar, rather than into the wall of the collar. The ring can comprise a continuous ring of piezoelectric material, or alternately arc segments or active ring segments of piezoelectric ceramic bonded to segments of other materials such as alumina to increase the frequency or heavy metals such as tungsten to reduce the frequency. The material and dimensions of the material used in-between the piezoelectric segments is chosen to alter the frequency of the ring.

Abstract: The present invention provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Compounds of formula (I) are also provided.