Publication number: 20240127367
Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.
Type:
Application
Filed:
August 25, 2023
Publication date:
April 18, 2024
Inventors:
David Patrick Perry, Geoffrey Albert von Maltzahn, Robert Berendes, Eric Michael Jeck, Barry Loyd Knight, Rachel Ariel Raymond, Ponsi Trivisvavet, Justin Y H Wong, Neal Hitesh Rajdev, Marc-Cedric Joseph Meunier, Casey James Leist, Pranav Ram Tadi, Andrea Lee Flaherty, Charles David Brummitt, Naveen Neil Sinha, Jordan Lambert, Jonathan Hennek, Carlos Becco, Mark Allen, Daniel Bachner, Fernando Derossi, Ewan Lamont, Rob Lowenthal, Dan Creagh, Steve Abramson, Ben Allen, Jyoti Shankar, Chris Moscardini, Jeremy Crane, David Weisman, Gerard Keating, Lauren Moores, William Pate
Publication number: 20240116972
Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.
Type:
Application
Filed:
November 15, 2023
Publication date:
April 11, 2024
Inventors:
Omar Moukha-Chafiq, Ashish Kumar Pathak, Shuklendu D. Karyakarte, Larry D. Bratton, Corinne E. Augelli-Szafran, Michael Diamond, Pei Yong Shi, Alec Jay Hirsch, Jessica Lee Smith, Daniel Streblow, Nicole Haese, Baoling Ying
Publication number: 20240109915
Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se
Type:
Application
Filed:
July 26, 2023
Publication date:
April 4, 2024
Applicant:
Pfizer Inc.
Inventors:
Scott William Bagley, Andrea Nicole Bootsma, Chulho Choi, Robert Lee Dow, David James Edmonds, Carmen Noemi Garcia-Irizarry, Brian Stephen Gerstenberger, Gajendra Ingle, Jessica Gloria Katherine O'Brien, Mihir Dineshkumar Parikh, Gwenaella Christine Rescourio, Daniel Copley Schmitt