Abstract: Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof, wherein the variables RA, RB and RC are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.

Abstract: Provided herein are compounds which mediate the activity of monoacyglycerol lipase (MAGL). Also provided are pharmaceutical compositions comprising a compound provided herein, and methods for treating, preventing and/or managing a MAGL mediated condition using a compound or pharmaceutical composition as provided herein.

Abstract: Substituted bicyclic heterocyclic compounds such as isoquinolinone compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.

Abstract: A sealing structure for a gas turbine engine includes a rotor that has a rim with slots and a cooling passage. The rotor is rotatable about an axis. First and second blades are arranged in the slots and respectively including first and second shelves facing one another within a pocket that is in fluid communication with the cooling passage. The first and second shelves form an opening. A reversible seal is arranged within the pocket and has a body that is configured for operative association with the first and second blades in any of four orientations to seal the opening in a first condition. The seal includes first and second protrusions respectively extending from first and second faces opposing one another. The first protrusions supported on the rim in a first condition.

Abstract: An assembly for a gas turbine that engine includes a fan section. A turbine section is configured to drive the fan section. The turbine section includes a rotor hub with a rotor lug. A heat shield engages the rotor lug. The heat shield and the rotor lug define a cooling passage.

Abstract: Additional document information may be stored through change tracking. In some examples, an application, such as a document processing application, may allow collaborative creation and/or editing of a document. As individual collaborators enter new content or make changes to existing content, the new content and/or changes go through two phases. As an individual collaborator is editing, the change is temporary. The collaborator may decide not to integrate it to the document. The temporary content may become permanent or integrated through a save action (manual or automatic). In some examples, the temporary content may be shared with other collaborators through a scheme to indicate its status as temporary giving the collaborators a true collaboration experience.

Abstract: Transfer of content between documents of different storage types is provided. Different versions of an endpoint (e.g., a productivity application) such as a mobile version and a desktop version, for example, may be enabled to process the same document and synchronize changes to the document content, even though the different versions or endpoints may use distinct formats for the same document.

Abstract: An adjustable belt for wearing around a user's waist is disclosed. The belt comprises a strap for placement around the user's waist. A buckle is coupled to a first end of the strap and is configured for accepting a second end of the strap and adjusting a length of the strap. The buckle further comprises a plurality of gears that mate with gear teeth located on an outward facing surface of the strap, such that movement of the second end of the strap within the buckle moves the plurality of gears; a spring loaded ratchet that contacts the gear teeth of the plurality of gears, such that the ratchet only allows movement of the plurality of gears in one direction; and a lever coupled to the spring loaded ratchet, such that activating the lever allows for movement of the plurality of gears in both directions.

Abstract: A rotor blade according to an exemplary aspect of the present disclosure includes, among other things, a platform, an airfoil that extends from the platform and a platform cooling passage extending inside of the platform. The platform cooling passage includes an inlet disposed through a non-gas path surface of the platform and an outlet disposed through a mate face of the platform.

Abstract: An exemplary gas turbine engine assembly includes a damping device having a first side and a second side facing away from the first side. The first side is configured to hold a seal when the second side engages an extension from a gas turbine engine component. The first side is further configured to engage the extension when the second side holds the seal.

Abstract: A damper-seal assembly for a gas turbine engine includes an additively manufactured seal and an additively manufactured damper inseparably assembled with the additively manufactured seal.

Abstract: In various embodiments, an airfoil used as a turbine blade for a turbine wheel in a gas turbine engine is provided. The airfoil may comprise a root, a tip, and a body. The root may have a first area. The tip may have a second area. The body may have a chord bounded by the root and the tip. The body may also define a cooling chamber. The cooling chamber may have a first rib substantially perpendicular to the chord. The cooling chamber may also have a second rib extending partially between the root and the tip.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Abstract: A seal and damper system is provided. The system comprises a blade assembly seal with a central portion defining a recess and a depression. The system also includes a damper comprising a center body and an arm extending from the center body and configured to engage the depression. A blade assembly is also provided comprising a blade platform, a seal configured to press against the blade platform, and a damper clipped onto the seal.

Abstract: An attachment root of an airfoil is provided. The attachment root may comprise a serration profile, a symmetry plane bisecting the serration profile, and a line perpendicular to the symmetry plane. A first lobe of the serration profile may have a first contact face angled 135 degrees from the line. A second lobe of the serration profile may have a second contact face angled 135 degrees from the line. A third lobe of the serration profile may have a third contact face angled 135 degrees from the line.

Abstract: An airfoil stage of a turbine engine includes an upstream airfoil assembly, a downstream airfoil assembly in rotational relationship to the upstream airfoil assembly and a rim seal assembly integrated therebetween. The rim seal assembly may include a sloped downstream portion of a platform of the upstream airfoil assembly, an upstream segment of a platform of the downstream airfoil assembly and a nub that projects radially outward from the upstream segment. The downstream portion and the upstream segment are spaced from one-another defining a cooling cavity therebetween for the flow of cooling air. The portion and segment overlap axially such that the nub is axially aligned to the downstream portion for improved cooling effectiveness and a reduction of core airflow into the cooling cavity.

Abstract: Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables RA, RB and RC are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.

Abstract: A segmented sideplate for use in a gas turbine engine is described. The segmented sideplate includes a first plate having a first circumferential edge configured to interface with a complementary circumferential edge. The segmented sideplate also includes a second plate having a second circumferential edge configured to interface with the first circumferential edge.