Patents by Inventor Daryoosh Vakhshoori
Daryoosh Vakhshoori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240159588Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: January 11, 2024Publication date: May 16, 2024Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Patent number: 11885681Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 28, 2022Date of Patent: January 30, 2024Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20230358709Abstract: In quartz-enhanced photoacoustic spectroscopy (QEPAS), an analyte (typically in gas phase) generates a pressure wave in response to incident laser light. A quartz tuning fork (QTF) resonant at the frequency of the pressure wave transduces the pressure wave into an electrical signal. Pulsing the laser briefly reduces the amount of thermal chirp and increases the fraction of time that the laser emits at the wavelength(s) of interest. This increases the measurement efficiency. Pulsing the incident laser light with bursts of short pulses at the QTF resonant frequency increases signal strength. Exciting the sample with a two pulses at different laser wavelengths, separated by a half QTF period yields signal and background acoustic waves that partially cancel when integrated by the QTF, producing a differential measurement. Pulsing the incident laser light at a frequency faster than the gas response cut off frequency can improve the noise performance of a QEPAS measurement.Type: ApplicationFiled: July 17, 2023Publication date: November 9, 2023Applicant: Pendar Technologies, LLCInventors: Romain BLANCHARD, Daryoosh VAKHSHOORI
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Patent number: 11717167Abstract: The inventors have developed tools for quantifying the mitochondrial redox state of in vivo, in situ tissue using resonance Raman spectroscopy. The tissue is illuminated with an excitation beam that causes the tissue to scatter Raman-shifted light, which is collected and analyzed to produce coefficients representing the relative concentrations of different chromophores in the tissue. These relative concentrations indicate the redox state of whole mitochondria, hemoglobin oxygen saturation, myoglobin oxygen saturation, and/or redox state of individual cytochrome complexes in mitochondria of the in vivo, in situ tissue. Quantifiable information about these states and/or saturations can be used to assess tissue health, including organ (dys)function before, during, and after surgery. For example, this information can be used to predict impending cardiac failure, to guide surgical interventions, to monitor organ health after transplantation, or to guide post-operative care.Type: GrantFiled: March 18, 2020Date of Patent: August 8, 2023Assignees: Pendar Technologies, LLC, Children's Medical Center CorporationInventors: John P. Romfh, Daryoosh Vakhshoori, John N. Kheir, Peili Chen, Brian Polizzotti, Joshua Salvin, Alison Perry
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Publication number: 20230109459Abstract: The present technology includes a system and method for monitoring a donor organ tissue using Raman spectroscopy. The technology enables real-time quantification of the mitochondrial redox state in the tissue sample taken from an organ intended for transplant using a compact device. The system is based on resonance Raman spectroscopy which can quantify a mitochondrial redox state in tissues using a Resonance Raman Reduced Mitochondrial Ratio. The mitochondrial redox state of the tissue sample acts as a marker of tissue function and may distinguish healthy versus damaged tissue. Moreover, these measures may correlate with transplantation outcomes.Type: ApplicationFiled: December 9, 2022Publication date: April 6, 2023Applicants: Pendar Technologies, LLC, The General Hospital CorporationInventors: John P. ROMFH, Daryoosh VAKHSHOORI, Peili CHEN, Shannon Tessier, Reinier De Vries, Stephanie Cronin
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Publication number: 20220373466Abstract: Apparatuses and methods for using Raman Resonance Spectroscopy to evaluate metabolic and oxygenation status of the eye are disclosed herein. In some embodiments, metabolic mapping of the eye may be performed by aligning a Raman spectrum and a recorded spatial image of the eye.Type: ApplicationFiled: October 27, 2020Publication date: November 24, 2022Applicants: Children's Medical Center Corporation, Pendar Technologies, LLCInventors: Lois Smith, Bertan D. Cakir, John Padraic Romfh, Pelli Chen, Daryoosh Vakhshoori
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Publication number: 20220333985Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 28, 2022Publication date: October 20, 2022Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Patent number: 11300448Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: December 22, 2020Date of Patent: April 12, 2022Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20210223100Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: December 22, 2020Publication date: July 22, 2021Inventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Publication number: 20210208108Abstract: In quartz-enhanced photoacoustic spectroscopy (QEPAS), an analyte (typically in gas phase) generates a pressure wave in response to incident laser light. A quartz tuning fork (QTF) resonant at the frequency of the pressure wave transduces the pressure wave into an electrical signal. Pulsing the laser briefly reduces the amount of thermal chirp and increases the fraction of time that the laser emits at the wavelength(s) of interest. This increases the measurement efficiency. Pulsing the incident laser light with bursts of short pulses at the QTF resonant frequency increases signal strength. Exciting the sample with a two pulses at different laser wavelengths, separated by a half QTF period yields signal and background acoustic waves that partially cancel when integrated by the QTF, producing a differential measurement. Pulsing the incident laser light at a frequency faster than the gas response cut off frequency can improve the noise performance of a QEPAS measurement.Type: ApplicationFiled: December 29, 2020Publication date: July 8, 2021Inventors: Romain BLANCHARD, Daryoosh VAKHSHOORI
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Patent number: 10921187Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: February 16, 2021Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10908129Abstract: In quartz-enhanced photoacoustic spectroscopy (QEPAS), an analyte (typically in gas phase) generates a pressure wave in response to incident laser light. A quartz tuning fork (QTF) resonant at the frequency of the pressure wave transduces the pressure wave into an electrical signal. Pulsing the laser briefly reduces the amount of thermal chirp and increases the fraction of time that the laser emits at the wavelength(s) of interest. This increases the measurement efficiency. Pulsing the incident laser light with bursts of short pulses at the QTF resonant frequency increases signal strength. Exciting the sample with a two pulses at different laser wavelengths, separated by a half QTF period yields signal and background acoustic waves that partially cancel when integrated by the QTF, producing a differential measurement. Pulsing the incident laser light at a frequency faster than the gas response cut off frequency can improve the noise performance of a QEPAS measurement.Type: GrantFiled: December 13, 2017Date of Patent: February 2, 2021Assignee: Pendar Technologies, LLCInventors: Romain Blanchard, Daryoosh Vakhshoori
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Publication number: 20200281474Abstract: The inventors have developed tools for quantifying the mitochondrial redox state of in vivo, in situ tissue using resonance Raman spectroscopy. The tissue is illuminated with an excitation beam that causes the tissue to scatter Raman-shifted light, which is collected and analyzed to produce coefficients representing the relative concentrations of different chromophores in the tissue. These relative concentrations indicate the redox state of whole mitochondria, hemoglobin oxygen saturation, myoglobin oxygen saturation, and/or redox state of individual cytochrome complexes in mitochondria of the in vivo, in situ tissue. Quantifiable information about these states and/or saturations can be used to assess tissue health, including organ (dys)function before, during, and after surgery. For example, this information can be used to predict impending cardiac failure, to guide surgical interventions, to monitor organ health after transplantation, or to guide post-operative care.Type: ApplicationFiled: March 18, 2020Publication date: September 10, 2020Inventors: John P. ROMFH, Daryoosh VAKHSHOORI, John N. KHEIR, Peili CHEN, Brian POLIZZOTTI, Joshua SALVIN, Alison PERRY
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Patent number: 10527495Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: January 7, 2020Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20190368938Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Publication number: 20190368927Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Publication number: 20190368939Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20190368937Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10488260Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: November 26, 2019Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10488252Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: November 26, 2019Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes