Abstract: The invention provides compositions and methods for treating celiac sprue.

Abstract: A log splitter is provided. The log splitter includes a housing, a power source, a motor within the housing and electrically coupled to the power source, a support arm coupled to and at least partially within the housing, a rack coupled to at least a portion of the support arm, and an actuation assembly at least partially within the housing and coupled to the motor and the rack. The power source may include at least one battery. The support arm extends between a first end and a second end. The rack is configured to move along the support arm in a forward direction to an extended position adjacent the first end of the support arm and a reverse direction toward to a starting position adjacent the second end of the support arm. The actuation assembly is configured to move the rack at least in the forward direction.

Abstract: Aspects of the present disclosure involve a system comprising a computer-readable storage medium storing a program and method for providing a reply interface with selectable stickers for sending in a message. The program and method provide for receiving, by a first device of a first user, a media content item provided by a second device of a second user; determining, in response to receiving the media content item, a set of stickers for displaying with the media content item; and displaying, by the first device, the media content item together with a first reply interface and a second reply interface for sending a reply message to the second device. The first reply interface includes the set of stickers, each of which is selectable by the first user for sending to the second device. The second reply interface includes an input box for sending message content to the second device.

Abstract: Various devices, systems, methods, and apparatuses utilize mechanical assemblies to prevent, detect, and/or mitigate objects from entering or moving close to or under a treadmill or exercise machine. In some embodiments, a guard, or guard assembly, is attached or otherwise fixed to a rear area of a treadmill. The guard assembly may include an end cap and pivoting guard configured to be retrofit to existing treadmills, such as to a rear end or area of a deck or frame of a treadmill.

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructure; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

Abstract: An apparatus for obstructing the passage of debris and providing ventilation through a region between a first object and a second object, the apparatus comprising: a body; and a plurality of tines extending from the body, wherein the tines are arranged in use such that when the body is connected to the first object, the tines extend across the region and flex against the second object leaving channels between the tines in the region allowing for ventilation.

Abstract: A lithotripsy device can comprise a handpiece, a lithotripsy probe extending from the handpiece, an energization source configured to deliver an energy to a distal end of the lithotripsy probe, a suction passage extending from the distal end of the probe and through the handpiece, and a capture device comprising a container comprising a storage space, an entry port configured to couple to the handpiece at the suction passage, and an exit port, and a capture element connected to the container and configured to facilitate capture of stone fragments within the storage space. A method can comprise fragmenting stones with a lithotripsy device, drawing a vacuum through the lithotripsy device to pull stone fragments and waste fluid therethrough, pulling the vacuum through a stone capture device connected to the lithotripsy device, depositing stone fragments within the stone capture device using a capture element, and drawing the vacuum through the device.

Abstract: Automated cold storage unit and systems for storing, monitoring, and maintaining a supply of temperature sensitive pharmaceutical and/or other products in compliance with regulatory requirements are provided. Such units contain an array of independently addressable holding locations for containers with product in one or more controlled temperature zones fitted with temperature sensors. The units include a reader to track product information and status. Product movement within the unit is performed by a computer-controlled robot. A user interface device, preferably in communication with an application service provider to provide remotely managed inventory management and other services, provides users with secure access to the contents of the unit and associated product data and information.

Abstract: In some examples, a method to present an affordance user interface element within a user interface of an interaction application includes detecting an association of a supplemental media content item with a primary media content item presented within the user interface. The supplemental media content item is identified from among a plurality of supplemental media content items supported by the interaction application. The method may include retrieving metadata related to the supplemental media content item and presenting, within the user interface, a supplementation affordance that presents the metadata. In some examples, the supplementation affordance is user selectable via the user interface to invoke a supplementation function that enables a user to apply the supplemental media content item to a further primary media content item. The supplementation function is invoked responsive to detecting a user selection of the supplementation affordance within the user interface.

Abstract: A sender holds a first platform account with an interaction system. The sender selects a content item to be shared with a recipient. In response to determining that a recipient identifier of the recipient is not linked to a platform account, an off-platform communication is transmitted to a second user device associated with the recipient identifier. The off-platform communication is in an electronic format supported by the second user device and contains a user-selectable registration link. In response to detecting establishment of a second platform account linked to the recipient identifier, the recipient is enabled to access the content item on the second user device via a user interface provided by an interaction application. A relationship between the first platform account and the second platform account is established within the interaction system.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: Provided is a method for review of an XBRL document. An XBRL document is received followed by a request to create an XBRL review for the XBRL document. A selection of an XBRL fact included in the XBRL document is received and a first review status, of a plurality of review statuses, is applied to the selected XBRL fact. The selected XBRL fact is monitored to detect a change to the XBRL fact, and in response to detecting a change to the XBRL fact, the first review status of the XBRL fact is updated to a second review status of the plurality of review statuses.

Abstract: A system comprising an aerosol provision system and a computer. The aerosol provision system is configured to generate aerosol from an aerosol-generating material. The computer is configured to obtain user behaviour data relating to an amount of an ingredient delivered from the aerosol-generating material to a user of the aerosol provision system. The computer then determines default user behaviour with respect to the amount of the ingredient to be delivered on the basis of the obtained user behaviour data. The computer then identifies, based on the obtained user behaviour, under what conditions to deliver a notification to the user, the notification informing the user of the user's current behaviour.

Abstract: A system comprising an aerosol provision system and a computer. The aerosol provision system is configured to generate aerosol from an aerosol-generating material. The computer is configured to obtain user behaviour data relating to an amount of an ingredient delivered from the aerosol-generating material to a user of the aerosol provision system. The computer then determines default user behaviour with respect to the amount of the ingredient to be delivered on the basis of the obtained user behaviour data. The computer then monitors a current interaction by the user with the aerosol provision system, and when the current user interaction deviates from the default user behaviour with respect to the amount of the ingredient delivered by a pre-determined amount, the computer provides a notification to the user.

Abstract: Stapling assemblies for use with a surgical stapler are provided. In one exemplary embodiment, the stapling assembly includes a cartridge having a plurality of staples disposed therein and a non-fibrous adjunct formed of at least one fused bioabsorbable polymer and configured to be releasably retained on the cartridge. Adjunct systems for use with a surgical stapler are also provided. Surgical end effectors using the stapling assemblies are also provided. Methods for manufacturing stapling assemblies and using the same are also provided.

Abstract: This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa0.5. This invention also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.

Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.

Abstract: A cooking accessory insert for a cooking grill includes a heat distribution duct that, installed, extends from a burner proximate to the bottom of the grill's fire box generally to a cooking level near the top of the fire box. The heat distribution duct is defined by a plurality of side walls extending from a top end of the heat distribution duct to a bottom end, tapering inward, or narrowing, from top to bottom. A top surface substantially covers the top end of the heat distribution duct, while the bottom is open. A cover is provided to cover the top surface, defining a baking chamber between the cover and the top surface. A cooking surface element such as a pizza stone is removably disposed on the top surface, spaced apart from the top surface by a plurality of spacers.

Abstract: A cooking apparatus can include an enclosure defining a heating chamber configured to be heated and used for cooking food, a burn box proximate to the enclosure and which is configured to provide heat to the heating chamber, a hopper fluidly coupled to the burn box and configured to hold fuel, and a fuel conditioner disposed between the hopper and the burner to condition the fuel prior to burning in the burner. The fuel conditioner can be, for example, a wood chipper configured to reduce the size of the fuel.