Abstract: Variable geometry turbines having new configurations of vanes are disclosed. New methods for designing new configurations of vanes for geometry turbines having are also disclosed.

Abstract: A turbine comprises a turbine wheel for rotation within a turbine housing, the turbine housing including at least one volute arranged to deliver a fluid to the turbine wheel via the turbine nozzle. A method for determining a width of a turbine nozzle for the turbine, comprises selecting from a relationship between a turbine stage efficiency and an effective nozzle area, at least one target effective nozzle area. As used here, the effective nozzle area is dependent on both the width of the turbine nozzle and a whirl angle induced by the at least one volute. The method further comprises determining, in dependence on the whirl angle, the width of the turbine nozzle as a width that will achieve the at least one target effective nozzle area.

Abstract: The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.

Abstract: The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form. The pharmaceutical compositions can be intravenously administered to a subject to treat fungal infections (e.g., candidiasis) in the subject.

Abstract: Non-visible objects which differ in their physical properties from their surroundings by association with a variable strength magnetic field may be detected by a suitable array of sensors which can be moved relative to the object in question. By analyzing the signals from the plurality of the sensors in the array, the position of the object can be deduced relative to the array and the array moved to enable a machining guide thereon to be aligned with the non-visible object. The system is of particular value in locating apertures in wing spars when attempting to fix the skin of the wing on to them where it is important to be able to locate the correct point at which to drill a hole through the skin to coincide with the hole in the spar. By defining a magnetic field in the vicinity of the hole to identify the hole magnetically and using an array of magnetic field sensors in a base with an aperture, it is possible to shift the array so that the aperture is precisely aligned with the non-visible hole.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet, vanes, extending from a nozzle ring though slots in a shroud, are shaped on one side to as to substantially conform to the profile of the surface of the slot, whereby a close connection can be formed between the vane and the slot to inhibit leakage of gas between the vane and the slot surface.

Abstract: The present invention generally relates to the field of dietary therapies for treating disorders associated with mitochondrial dysfunction, including epilepsy.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: A method performed by a processor for permuting dimensions of a multi-dimensional tensor is described. The multi-dimensional tensor contains an array of tensor values in three or more dimensions that are stored in a first storage unit. The array of tensor values is transferred from the first storage unit to a second storage unit by reading tensor values from the first storage that are arrayed along a first dimension of the multi-dimensional tensor and writing the corresponding tensor values to the second storage in locations corresponding to a second dimension of the multi-dimensional tensor. The dimensions of the multi-dimensional tensor may be further permuted by a programmable engine within the processor.

Abstract: A uterine manipulator device includes: an elongated cannulated tube comprising a proximal end and a distal end; a cervical cup having a top proximal portion of a first diameter and a base distal portion of a second smaller diameter, wherein: the base distal portion includes a hole formed therein having a perimeter including a distal end and a proximal end, and including a longitudinal axis positioned therethrough; one of the proximal end of the perimeter and the distal end of the perimeter is angled away from the longitudinal axis and the other of the proximal end of the perimeter and the distal end of the perimeter is in line with the longitudinal axis; and the elongated cannulated tube is positioned through the hole in the cervical cup.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: The present invention generally relates to the field of dietary therapies for treating disorders associated with mitochondrial dysfunction, including epilepsy.

Abstract: An ultrasonic device, the device comprising at least one flexible ultrasonic transducer; and a clamp configured to mount the at least one transducer to a test object. Optionally, the clamp may comprise one or more bands and wherein the one or more bands can optionally be metal or at least part of the one or more bands may be formed of a conformable material such that the one or more bands comprises a conformable band or band portion.

Abstract: A method performed by a processor for permuting dimensions of a multi-dimensional tensor is described. The multi-dimensional tensor contains an array of tensor values in three or more dimensions that are stored in a first storage unit. The array of tensor values is transferred from the first storage unit to a second storage unit by reading tensor values from the first storage that are arrayed along a first dimension of the multi-dimensional tensor and writing the corresponding tensor values to the second storage in locations corresponding to a second dimension of the multi-dimensional tensor. The dimensions of the multi-dimensional tensor may be further permuted by a programmable engine within the processor.

Abstract: A uterine manipulator device includes: an elongated cannulated tube comprising a proximal end and a distal end; a cervical cup having a top proximal portion of a first diameter and a base distal portion of a second smaller diameter, wherein: the base distal portion includes a hole formed therein having a perimeter including a distal end and a proximal end, and including a longitudinal axis positioned therethrough; one of the proximal end of the perimeter and the distal end of the perimeter is angled away from the longitudinal axis and the other of the proximal end of the perimeter and the distal end of the perimeter is in line with the longitudinal axis; and the elongated cannulated tube is positioned through the hole in the cervical cup.

Abstract: A turbine with multiple gas inlets is designed by a process of, for a given engine, obtaining time series data characterizing the power bias of the engine, obtaining an isentropic power associated with each data point of the time series, and using the isentropic powers to obtain a design point. The turbine is then designed based on the design point, such as by optimising one or more design parameters of the turbine based on the design point.

Abstract: The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form. The pharmaceutical compositions can be intravenously administered to a subject to treat fungal infections (e.g., candidiasis) in the subject.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: A turbine comprises a housing defining a turbine chamber with a turbine wheel supported for rotation about an axis. The housing further defines first and second inlet volutes which each spiral radially inwards and extend from a respective inlet to adjoin the turbine chamber and a volute tongue for each inlet volute. The tongue of the first volute radially separating a downstream portion of the first volute adjacent the chamber from an upstream portion of the first volute adjacent said inlet of the first volute, and the tongue of the second volute radially separating a downstream portion of the second volute adjacent the chamber from an upstream portion of the second volute adjacent said inlet of the second volute. The tongues having a turbine scroll tongue overlap which is substantially zero or positive; and the first volute tongue is angularly spaced about the axis from the second volute tongue.

Abstract: A downhole tool having a mandrel, and a bottom slip disposed around the mandrel. The bottom slip includes a circular body having a one-piece configuration characterized by a plurality of slip segments by at least partial material connectivity therearound. The bottom slip is made of a filament wound composite material, which means the bottom slip has a plurality of layers joined by respective interface layers. An outer slip surface of at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle a1 when the bottom slip is in an unset position.