Abstract: An erroneous transmission, of a record of data, to a distributed ledger system can be prevented. A first operation can confirm that a format of a content within the record of data is correct. A second operation can confirm that formats of elements of a set of information, about authorizations used to cause the record of data to be communicated via the distributed ledger system, are correct. A third operation can confirm that subject matters of the elements and a subject matter of the record of data are the same. A fourth operation can retrieve credentials associated with entities that produced the elements. A fifth operation, using the credentials, can confirm that the entities that produced the elements were authorized to produce them. A sixth operation can confirm that the set of information is sufficient to authorize causing the record of data to be communicated via the distributed ledger system.

Abstract: Methods, computer readable media, and devices for escrow of master keys and recovery of previously escrowed master keys may be disclosed. A method for escrow of master keys may include registering a root certificate authority (CA) within each of two first-party hardware security modules (HSMs), initializing each of three third-party HSMs as master escrow recovery devices, performing a bootstrap operation on an authoritative blockchain to generate three master keys, generating a first set of master key shard ciphertexts using a first one of the three master escrow recovery devices, a second set using a second one of the three master escrow recovery devices, and a third set using a third one of the three master escrow recovery devices, and storing the first, the second, and the third set of master key shard ciphertexts as opaque objects in each of the two first-party HSMs.

Abstract: A system to detect and resolve conflicts between different experiments running on a website building system (WBS). The system includes at least one processor, a conflict resolver to check for interactions and conflicts between an experiment and at least one other existing experiment from a set of existing experiments in the WBS, when the experiment is set-up or integrated into the set of existing experiments. The conflict resolver either resolves the interactions and conflicts, or allows the interactions and conflicts to remain. The system also includes an experiment manager running on the at least one processor to manage and coordinate the experiment and the at least one other existing experiment when the experiment is running concurrently with the at least one other existing experiment, after set-up or integration of the experiment.

Abstract: Tooling and corresponding tool assembly configurations equipped with exemplary designs of tracking assemblies configured to track information, such as use history, and perform a variety of processing and storage functions relative to the same for more efficient use and maintenance of the tooling over their lifetimes. The tracking assemblies can have retrofit-ready constructions.

Abstract: An erroneous transmission, of a record of data, to a distributed ledger system can be prevented. A first operation can confirm that a format of a content within the record of data is correct. A second operation can confirm that formats of elements of a set of information, about authorizations used to cause the record of data to be communicated via the distributed ledger system, are correct. A third operation can confirm that subject matters of the elements and a subject matter of the record of data are the same. A fourth operation can retrieve credentials associated with entities that produced the elements. A fifth operation, using the credentials, can confirm that the entities that produced the elements were authorized to produce them. A sixth operation can confirm that the set of information is sufficient to authorize causing the record of data to be communicated via the distributed ledger system.

Abstract: A website building system (WBS) that enables web site designers to build and host websites for their end users. The WBS includes at least one processor and an experiment manager running on the at least one processor to manage multiple concurrent experiments at runtime with the experiments to test at least features, components or system updates for the WBS and where the experiment manager at least selects a target population for an experiment, handles conflict resolution between the experiment and at least one other concurrent experiment, and collects experiment data. The WBS also includes an experiment analyzer to analyze the experiment data during runtime and to update the experiment manager accordingly.

Abstract: The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Abstract: The present disclosure provides high-performance immunoreagents for use in a variety of immunologic assays and other related techniques. The immunoreagents comprise a primary antibody and a bridging antigen, wherein the bridging antigen is recognized by a detectable secondary antibody with high affinity. Also provided are compositions comprising panels of immunoreagents specific for multiple different target antigens and compositions comprising pairs of primary immunoreagents and their complementary detectable secondary antibodies. The paired primary immunoreagents and secondary antibodies are useful in a variety of immunologic assays, particularly in highly multiplexed assays, where the structure of the bridging antigen is varied in tandem with variation in the detectable secondary antibody, such that a multiplicity of immunoreagents are provided that are capable of simultaneously detecting a multiplicity of target antigens in a single assay.

Abstract: A gas monitor apparatus includes a sorbent material that adsorbs a target gas based on a concentration of the target gas in a monitored environment and a reference material that does not respond to the target gas. The gas monitor also includes a first thermistor disposed within the sorbent material and a second thermistor disposed within the reference material, the first thermistor to provide a first indication of a first temperature of the sorbent material and the second thermistor to provide a second indication of a second temperature of the reference material. A processing device determines a concentration of the target gas based at least in part on a differential measurement between the first temperature and the second temperature.

Abstract: Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.

Abstract: The present disclosure provides methods, compositions, and kits for trapping functionalized biomolecules. The methods, compositions, and kits utilize a trapping material comprising a reactive carbonyl group. The trapping material is designed to react rapidly and efficiently with a functionalized biomolecule that comprises a reactive amino group, thus removing the functionalized biomolecule from solution. The trapping material is therefore effective in the purification of target molecules after labeling reactions with an excess of the functionalized biomolecule.

Abstract: An incorrect transmission, of a record of data to a distributed ledger system, can be prevented. A first signal can be received. The first signal can include a first instruction to cause the record to be transmitted to the system. One or more items of information in the record can be determined. A delay of time to be elapsed, before a transmission of the record to the system, can be set in response to a receipt of the first signal and a determination of the one or more items. The transmission of the record to the system can be caused to occur after the delay has elapsed. The transmission of the record to the system can be prevented in response to a receipt of a second signal before the delay has elapsed. The second signal can include a second instruction that supersedes the first instruction.

Abstract: A gas monitor apparatus includes a sorbent material that adsorbs a target gas based on a concentration of the target gas in a monitored environment and a reference material that does not respond to the target gas. The gas monitor also includes a first thermistor disposed within the sorbent material and a second thermistor disposed within the reference material, the first thermistor to provide a first indication of a first temperature of the sorbent material and the second thermistor to provide a second indication of a second temperature of the reference material. A processing device determines a concentration of the target gas based at least in part on a differential measurement between the first temperature and the second temperature.

Abstract: The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Abstract: Methods, systems, apparatuses, and computer program products are provided for enabling access to a resource in a secured manner. A token request from an application executing in a first computing environment may be received in a second computing environment. The second computing environment may assign a trust level to the received token request that indicates that the first computing environment may not be trusted. The token request, along with the trust level, may be provided to an authorization server to generate an authorization token that includes a trust indication indicative of the trust level of the second computing environment. When the application executing in the second computing environment transmits the authorization token to a resource manager to access a resource, the resource manager may be configured to perform a precautionary action to protect the resource prior to providing access, such as creating a backup of the resource.

Abstract: A website building system (WBS) that enables web site designers to build and host websites for their end users. The WBS includes at least one processor and an experiment manager running on the at least one processor to manage multiple concurrent experiments at runtime with the experiments to test at least features, components or system updates for the WBS and where the experiment manager at least selects a target population for an experiment, handles conflict resolution between the experiment and at least one other concurrent experiment, and collects experiment data. The WBS also includes an experiment analyzer to analyze the experiment data during runtime and to update the experiment manager accordingly.

Abstract: An erroneous transmission, of a record of data, to a distributed ledger system can be prevented. A first operation can confirm that a format of a content within the record of data is correct. A second operation can confirm that formats of elements of a set of information, about authorizations used to cause the record of data to be communicated via the distributed ledger system, are correct. A third operation can confirm that subject matters of the elements and a subject matter of the record of data are the same. A fourth operation can retrieve credentials associated with entities that produced the elements. A fifth operation, using the credentials, can confirm that the entities that produced the elements were authorized to produce them. A sixth operation can confirm that the set of information is sufficient to authorize causing the record of data to be communicated via the distributed ledger system.

Abstract: Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.

Abstract: An experiment management system for an online visual design system including an experiment creator to receive an experiment specification with source material from an external source and to create an experiment definition based on inspection and analysis of the source material; an experiment integrator to integrate the experiment definition as an experiment into the experiment management system; an experiment configurer to configure a variant and population selection criteria for the experiment and an experiment manager to manage the experiment and at least one other experiment during the execution of the experiment at runtime of the online visual design system according to the variant and population selection.

Abstract: An incorrect copy of a record of data can be prevented from being transmitted to a distributed ledger system. A first file can be received and can include information, in audio or video form, with a description of a subject matter of the record of data and with an authorization to transmit the copy to the distributed ledger system. The first file can be sent to a device. A second file can be received from the device and can include information that confirms that the description of the subject matter, included in the first file, is correct, and that confirms that an entity, which controlled production of the first file, has permission to authorize causing the copy to be transmitted to the distributed ledger system. The correct copy can be caused, based on a receipt of the first and the second files, to be transmitted to the distributed ledger system.