Patents by Inventor David Apelian

David Apelian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast-brachyury immunotherapeutic compositions
    Patent number: 11944673
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: April 2, 2024
    Assignees: The USA, as represented by the Secretary, Dept. of Health and Human Services, GlobeImmune, Inc.
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Yeast-brachyury immunotherapeutic compositions
    Patent number: 11938175
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: March 26, 2024
    Assignees: The USA, as represented by the Secretary, Dept. of Health and Human Services, GlobeImmune, Inc.
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • YEAST-BRACHYURY IMMUNOTHERAPEUTIC COMPOSITIONS
    Publication number: 20210106666
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Application
    Filed: December 21, 2020
    Publication date: April 15, 2021
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
    Patent number: 10849971
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: December 1, 2020
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • YEAST-BASED IMMUNOTHERAPY FOR CHORDOMA
    Publication number: 20200046818
    Abstract: Disclosed are methods of the treatment or prevention of chordoma which include the step of administering a yeast-based immunotherapeutic composition. The yeast-based immunotherapeutic composition preferably comprises a Brachyury antigen.
    Type: Application
    Filed: October 25, 2019
    Publication date: February 13, 2020
    Inventors: Timothy C. RODELL, David APELIAN, Claudia PALENA, Jeffrey SCHLOM
  • Yeast-based immunotherapy for Chordoma
    Patent number: 10507235
    Abstract: One embodiment of the invention relates to a method to treat chordoma in an individual who has chordoma. The method includes the step of administering to an individual who has chordoma, an immunotherapeutic composition comprising: (a) a yeast vehicle; and (b) a cancer antigen comprising at least one Brachyury antigen. Another embodiment of the invention relates to the use of an immunotherapeutic composition comprising a yeast vehicle and a cancer antigen comprising at least one Brachyury antigen to chordoma in an individual who has chordoma. Yet another embodiment of the invention relates to the use an immunotherapeutic composition comprising a yeast vehicle.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: December 17, 2019
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Timothy C. Rodell, David Apelian, Claudia Palena, Jeffrey Schlom
  • YEAST-BRACHYURY IMMUNOTHERAPEUTIC COMPOSITIONS
    Publication number: 20190374624
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Application
    Filed: April 19, 2019
    Publication date: December 12, 2019
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Compositions and methods for the treatment or prevention of hepatitis B virus infection
    Patent number: 10441650
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: October 15, 2019
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    Publication number: 20190240320
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Application
    Filed: April 19, 2019
    Publication date: August 8, 2019
    Inventors: Thomas H. KING, David APELIAN
  • Yeast-brachyury immunotherapeutic compositions
    Patent number: 10363294
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: July 30, 2019
    Assignees: GlobeImmune, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
    Patent number: 10265393
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 23, 2019
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • Compositions and Methods for the Treatment or Prevention of Hepatitis B Virus Infection
    Publication number: 20180311339
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Application
    Filed: March 1, 2018
    Publication date: November 1, 2018
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    Publication number: 20180177865
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Application
    Filed: September 7, 2017
    Publication date: June 28, 2018
    Inventors: Thomas H. KING, David APELIAN
  • Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection
    Patent number: 9987352
    Abstract: Disclosed are immunotherapeutic compositions and methods for preventing and/or treating hepatitis delta virus (HDV) infection, including yeast-based HDV immunotherapeutic compositions and methods of use of such compositions to prevent and/or treat HDV infection and symptoms and sequela thereof.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: June 5, 2018
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • Compositions and methods for the treatment or prevention of hepatitis B virus infection
    Patent number: 9943591
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: April 17, 2018
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • COMBINATION DRUG TREATMENT FOR HEPATITIS C INFECTION
    Publication number: 20180021361
    Abstract: A method for the treatment of hepatitis C infection genotype 1, 2, 4, 5, or 6 is provided comprising administering an effective amount of a combination of Compound (I), Compound (II), and Compound (III), or independently optionally their pharmaceutically acceptable salt, solvate or hydrate, optionally in a solid fixed dose composition.
    Type: Application
    Filed: July 21, 2017
    Publication date: January 25, 2018
    Applicants: JANSSEN PHARMACEUTICALS, INC., ACHILLION PHARMACEUTICALS, INC.
    Inventors: Maria Gloria Beumont, Lieve Bijnens, Lawrence M. Blatt, Sushmita Mukherjee Chanda, John Fry, Eugene Jans, Thomas Naoki Kakuda, Sivi Mahadevan, Roel Mertens, Gaston Rafael Picchio, Alex Van Dijck, Peter Van Remoortere, David Apelian, Dawei Chen, Milind Deshphande, James Hui, Avinash Phadke
  • Combination Therapy Regimen For Treatment Of Selected HCV Genotypes
    Publication number: 20180021360
    Abstract: A method for the treatment of hepatitis C infection genotype 1, 2, 4, 5, or 6, but not genotype 3 is provided comprising administering an effective amount of a combination of Compound (I), Compound (II), and Compound (III), or independently optionally their pharmaceutically acceptable salt, solvate or hydrate, optionally in a solid fixed dose composition.
    Type: Application
    Filed: July 21, 2017
    Publication date: January 25, 2018
    Applicants: Janssen Pharmaceuticals, Inc., Achillion Pharmaceuticals, Inc.
    Inventors: Maria Gloria Beumont, Lieve Bijnens, Lawrence M. Blatt, Sushmita Mukherjee Chanda, John Fry, Eugene Jans, Thomas Naoki Kakuda, Sivi Mahadevan, Roel Mertens, Gaston Rafael Picchio, Alex Van Dijck, Peter Van Remoortere, David Apelian, Dawei Chen, Milind Deshphande, James Hui, Avinash Phadke
  • COMBINATION DRUG TREATMENT FOR HEPATITIS C INFECTION
    Publication number: 20170319572
    Abstract: A composition, including a fixed dose composition, comprising Compound (I), Compound (II), and Compound (III) for the treatment of hepatitis C, and methods of manufacture thereof.
    Type: Application
    Filed: July 25, 2017
    Publication date: November 9, 2017
    Applicants: JANSSEN PHARMACEUTICALS, INC., ACHILLION PHARMACEUTICALS, INC.
    Inventors: Maria Gloria Beumont, Lieve Bijnens, Lawrence M. Blatt, Sushmita Mukherjee Chanda, John Fry, Eugene Jans, Thomas Naoki Kakuda, Sivi Mahadevan, Roel Mertens, Gaston Rafael Picchio, Alex Van Dijck, Peter Van Remoortere, David Apelian, Dawei Chen, Milind Deshphande, James Hui, Avinash Phadke
  • Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
    Patent number: 9782473
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: October 10, 2017
    Assignee: GLOBEIMMUNE, INC.
    Inventors: Thomas H. King, David Apelian
  • YEAST-BRACHYURY IMMUNOTHERAPEUTIC COMPOSITIONS
    Publication number: 20170246276
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Application
    Filed: March 9, 2017
    Publication date: August 31, 2017
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom