Patents by Inventor David Apelian

David Apelian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • YEAST-BASED COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF HEPATITIS DELTA VIRUS INFECTION
    Publication number: 20170182153
    Abstract: Disclosed are immunotherapeutic compositions and methods for preventing and/or treating hepatitis delta virus (HDV) infection, including yeast-based HDV immunotherapeutic compositions and methods of use of such compositions to prevent and/or treat HDV infection and symptoms and sequela thereof.
    Type: Application
    Filed: January 17, 2017
    Publication date: June 29, 2017
    Inventors: Thomas H. King, David Apelian
  • Yeast-brachyury immunotherapeutic compositions
    Patent number: 9623097
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: April 18, 2017
    Assignees: GlobeImmune, Inc., The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • COMBINATION THERAPY REGIMEN FOR TREATMENT OF HCV
    Publication number: 20170087174
    Abstract: A composition, including a fixed dose composition, comprising Compound (I), Compound (II), and Compound (III) for the treatment of hepatitis C, and methods of manufacture thereof.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 30, 2017
    Inventors: Maria Gloria Beumont, Lieve Bijnens, Lawrence M. Blatt, Sushmita Mukherjee Chanda, John Fry, Eugene Jans, Thomas Naoki Kakuda, Sivi Mahadevan, Roel Mertens, Gaston Rafael Picchio, Alex Van Dijck, Peter Van Remoortere, David Apelian, Dawei Chen, Milind Deshphande, James Hui, Avinash Phadke
  • Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection
    Patent number: 9579377
    Abstract: Disclosed are immunotherapeutic compositions and methods for preventing and/or treating hepatitis delta virus (HDV) infection, including yeast-based HDV immunotherapeutic compositions and methods of use of such compositions to prevent and/or treat HDV infection and symptoms and sequela thereof.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: February 28, 2017
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • Compositions and Methods for the Treatment or Prevention of Hepatitis B Virus Infection
    Publication number: 20170000879
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Application
    Filed: July 18, 2016
    Publication date: January 5, 2017
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • YEAST-BASED IMMUNOTHERAPY FOR CHORDOMA
    Publication number: 20160271238
    Abstract: One embodiment of the invention relates to a method to treat chordoma in an individual who has chordoma. The method includes the step of administering to an individual who has chordoma, an immunotherapeutic composition comprising: (a) a yeast vehicle; and (b) a cancer antigen comprising at least one Brachyury antigen. Another embodiment of the invention relates to the use of an immunotherapeutic composition comprising a yeast vehicle and a cancer antigen comprising at least one Brachyury antigen to chordoma in an individual who has chordoma. Yet another embodiment of the invention relates to the use an immunotherapeutic composition comprising a yeast vehicle.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 22, 2016
    Inventors: Timothy C. RODELL, David APELIAN, Claudia PALENA, Jeffrey SCHLOM
  • Compositions and methods for the treatment or prevention of hepatitis B virus infection
    Patent number: 9428556
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: August 30, 2016
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • YEAST-BRACHYURY IMMUNOTHERAPEUTIC COMPOSITIONS
    Publication number: 20160106824
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Application
    Filed: October 29, 2015
    Publication date: April 21, 2016
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Yeast-based therapeutic for chronic hepatitis B infection
    Patent number: 9290547
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: March 22, 2016
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    Publication number: 20160045592
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Application
    Filed: March 26, 2014
    Publication date: February 18, 2016
    Inventors: Thomas H. KING, David APELIAN
  • Compositions and methods for the treatment or prevention of human adenovirus-36 infection
    Patent number: 9254320
    Abstract: Disclosed are fusion proteins, recombinant nucleic acid molecules, and therapeutic compositions, including yeast-based immunotherapy compositions, for use in the diagnosis, prevention and treatment of adenovirus-36 (Ad-36) infection and sequela thereof.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: February 9, 2016
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas King, Claire Coeshott, Yingnian Lu
  • Yeast-Brachyury immunotherapeutic compositions
    Patent number: 9198941
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 1, 2015
    Assignees: The United States of America, as represented by the Secretary, Dept. of Health and Human Services, GlobeImmune, Inc.
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Compositions and Methods for the Treatment or Prevention of Hepatitis B Virus Infection
    Publication number: 20150191509
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Application
    Filed: January 7, 2015
    Publication date: July 9, 2015
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • YEAST-BASED THERAPEUTIC FOR CHRONIC HEPATITIS B INFECTION
    Publication number: 20150110828
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Application
    Filed: September 23, 2014
    Publication date: April 23, 2015
    Inventors: David APELIAN, Thomas H. KING, Zhimin GUO, Claire COESHOTT
  • Compositions and methods for the treatment or prevention of hepatitis B virus infection
    Patent number: 8961988
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: February 24, 2015
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • Yeast-based therapeutic for chronic hepatitis B infection
    Patent number: 8877205
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: November 4, 2014
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • Compositions and Methods for the Treatment or Prevention of Hepatitis B Virus Infection
    Publication number: 20140286984
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Application
    Filed: February 19, 2014
    Publication date: September 25, 2014
    Applicant: Globelmmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • Compositions and Methods for Eliciting an Immune Response to Escape Mutants of Targeted Therapies
    Publication number: 20140234375
    Abstract: Provided herein are cells, vectors and viruses in association with a mutant polypeptide that has emerged in response to a therapeutic or prophylactic agent; compositions comprising such cells, vectors and viruses and methods for their use in eliciting an immune response to the mutant polypeptide. In some examples, the immune response is a cellular immune response.
    Type: Application
    Filed: December 17, 2013
    Publication date: August 21, 2014
    Applicant: Globelmmune, Inc.
    Inventors: David Apelian, Alex Franzusoff, Timothy C. Rodell
  • Immunotherapy for chronic hepatitis C virus infection
    Patent number: 8728489
    Abstract: Disclosed are uses of immunotherapeutic compositions in combination with Standard of Care (SOC), or interferon therapy combined with anti-viral therapy, for the improved treatment of chronic hepatitis C virus (HCV) infection and related conditions, including liver function. The compositions, kits and uses of the invention, as compared to the use of SOC therapy alone: improves the rate of early response to therapy as measured by early virologic markers (e.g., RVR and EVR), enlarges the pool of patients who will have sustained responses to therapy over the long term, offers shortened courses of therapy for certain patients, enables “rescue” of patients who are non-responders or intolerant to SOC therapy, improves liver function and/or reduces liver damage in patients, and enables the personalization of HCV therapy for a patient, which can result in dose sparing, improved patient compliance, reduced side effects, and improved long term therapeutic outcomes.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: May 20, 2014
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Richard C. Duke, Alex Franzusoff
  • Compositions and methods for the treatment or prevention of hepatitis B virus infection
    Patent number: 8722054
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: May 13, 2014
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott