Patents by Inventor David C. Duffy
David C. Duffy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120289428Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.Type: ApplicationFiled: June 22, 2012Publication date: November 15, 2012Applicant: Quanterix CorporationInventors: David C. Duffy, David M. Rissin, David R. Walt, David Fournier, Cheuk Kan
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Publication number: 20120277114Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.Type: ApplicationFiled: June 22, 2012Publication date: November 1, 2012Applicant: Quanterix CorporationInventors: David C. Duffy, David M. Rissin, David R. Walt, David Fournier, Cheuk Kan
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Patent number: 8236574Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.Type: GrantFiled: March 24, 2010Date of Patent: August 7, 2012Assignee: Quanterix CorporationInventors: David C. Duffy, David M. Rissin, David R. Walt, David Fournier, Cheuk Kan
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Publication number: 20120196774Abstract: Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.Type: ApplicationFiled: February 25, 2011Publication date: August 2, 2012Applicant: Quanterix CorporationInventors: David Fournier, Todd Campbell, Cheuk Kan, John Lawson, Andrew Rivnak, Michael Kagan, David C. Duffy
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Patent number: 8222047Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.Type: GrantFiled: September 23, 2008Date of Patent: July 17, 2012Assignee: Quanterix CorporationInventors: David C. Duffy, Evan Ferrell, Jeffrey D. Randall, David M. Rissin, David R. Walt
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Publication number: 20110277930Abstract: A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and for irradiating a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample.Type: ApplicationFiled: February 18, 2011Publication date: November 17, 2011Applicant: President and Fellows of Harvard CollegeInventors: Olivier J.A. Schueller, David C. Duffy, John A. Rogers, Scott T. Brittain, George M. Whitesides
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Publication number: 20110245097Abstract: Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.Type: ApplicationFiled: March 1, 2011Publication date: October 6, 2011Applicant: Quanterix CorporationInventors: David M. Rissin, David Fournier, David C. Duffy
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Publication number: 20110212848Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.Type: ApplicationFiled: March 24, 2010Publication date: September 1, 2011Applicant: Quanterix CorporationInventors: David C. Duffy, David M. Rissin, David R. Walt, David Fournier, Cheuk Kan
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Publication number: 20110212462Abstract: Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand.Type: ApplicationFiled: March 24, 2010Publication date: September 1, 2011Applicant: Quanterix CorporationInventors: David C. Duffy, David M. Rissin, David R. Walt, Linan Song, Lei Chang
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Publication number: 20110212537Abstract: Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.Type: ApplicationFiled: March 24, 2010Publication date: September 1, 2011Applicant: Quanterix CorporationInventors: David M. Rissin, David Fournier, David C. Duffy
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Patent number: 7919172Abstract: A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and for irradiating a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample.Type: GrantFiled: April 14, 2004Date of Patent: April 5, 2011Assignee: President and Fellows of Harvard CollegeInventors: Olivier J. A. Schueller, David C. Duffy, John A. Rogers, Scott T. Brittain, George M. Whitesides
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Publication number: 20100075407Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.Type: ApplicationFiled: September 23, 2008Publication date: March 25, 2010Applicant: Quanterix CorporationInventors: David C. Duffy, Evan Ferrell, Jeff Randall, David M. Rissin, David R. Walt
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Publication number: 20100075439Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.Type: ApplicationFiled: September 23, 2008Publication date: March 25, 2010Applicant: Quanterix CorporationInventors: David C. Duffy, Evan Ferrell, Jeff Randall, David M. Rissin, David R. Walt
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Publication number: 20100075862Abstract: The present invention relates to methods, systems, and kits for detecting, quantifying and/or analyzing a fluid sample comprising molecules or particles at low concentration. In certain embodiments, the methods for detection and/or quantifying analyte molecules in a sample comprise capturing a plurality of analyte molecules on a substrate (e.g., an array comprising a plurality of reaction vessels). The substrate may then be exposed to additional reaction components such as at least one binding ligand. The substrate may additionally be exposed to a precursor labeling agent molecule, wherein the precursor labeling agent molecule, in some cases, is converted to a labeling agent molecule, which may be detected, either directly or indirectly, which determination may be related to the presence of and/or may be employed to quantify the analyte molecules.Type: ApplicationFiled: September 23, 2008Publication date: March 25, 2010Applicant: Quanterix CorporationInventors: David C. Duffy, David M. Rissin, Linan Song, David R. Walt
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Publication number: 20100075355Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.Type: ApplicationFiled: September 23, 2008Publication date: March 25, 2010Applicant: Quanterix CorporationInventors: David C. Duffy, Evan Ferrell, Jeffrey D. Randall, David M. Rissin, David R. Walt
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Patent number: 7282240Abstract: An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.Type: GrantFiled: October 20, 2000Date of Patent: October 16, 2007Assignee: President and Fellows of Harvard CollegeInventors: Rebecca J. Jackman, David C. Duffy, George M. Whitesides, Kathleen Vaeth, Klavs F. Jensen
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Patent number: 6893850Abstract: The present invention provides a masking system for selectively applying cells to predetermined regions of a surface. A mask is positioned adjacent to a surface to cover some portions of the surface while allowing other portions of the surface to remain uncovered. Cells then are applied to uncovered portions of the surface and the mask removed. Alternatively, a cell-adhesion promoter is applied to uncovered portions of the surface, and then cells are applied to the surface before or after removal of the mask from the surface. The masking system can be pre-coated, at least on those surfaces which will come into contact with cells, with a cell-adhesion inhibitor to resist absorption of cells and thereby avoid cell damage when the mask is removed (if cells are deposited prior to removal of the mask). A polymeric elastomeric mask that comes into cohesive-conformal contact with a surface to be patterned can be used.Type: GrantFiled: March 15, 2001Date of Patent: May 17, 2005Assignee: President and Fellows of Harvard CollegeInventors: Emanuele Ostuni, Ravi Kane, George M. Whitesides, Rebecca J. Jackman, David C. Duffy
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Patent number: 6747285Abstract: A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and for irradiating a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample.Type: GrantFiled: November 1, 2001Date of Patent: June 8, 2004Assignee: President and Fellows of Harvard CollegeInventors: Olivier J. A. Schueller, David C. Duffy, John A. Rogers, Scott T. Brittain, George M. Whitesides
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Patent number: 6719868Abstract: A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and to irradiate a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample.Type: GrantFiled: October 22, 1999Date of Patent: April 13, 2004Assignee: President and Fellows of Harvard CollegeInventors: Olivier J. A. Schueller, David C. Duffy, John A. Rogers, Scott T. Brittain, George M. Whitesides
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Publication number: 20030232403Abstract: This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. These assays may be performed for a variety of purposes, including but not limited to screening of drug candidate compounds, life sciences research, and clinical and molecular diagnostics. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.Type: ApplicationFiled: June 24, 2003Publication date: December 18, 2003Inventors: Gregory L. Kellogg, David C. Duffy